发明公开
- 专利标题: IODINATED X-RAY CONTRAST MEDIA
- 专利标题(中): 碘化X射线造影剂
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申请号: EP95932109.0申请日: 1995-09-22
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公开(公告)号: EP0782564A1公开(公告)日: 1997-07-09
- 发明人: ALMEN, Torsten , ANDERSSON, Sven , WISTRAND, Lars-Göran , GOLMAN, Klaes , ANTONSEN, Oyvind , FOSSHEIM, Rune , WIGGEN, Unni, Nordby , WIKSTRÖM, Häkan, Medicinal Chemistry unit , KLINGSTEDT, Tomas , LEUNBACH, Ib , BERG, Arne , DUGSTAD, Harald
- 申请人: NYCOMED IMAGING AS
- 申请人地址: Nycoveien 1-2 0401 Oslo 4 NO
- 专利权人: NYCOMED IMAGING AS
- 当前专利权人: NYCOMED IMAGING AS
- 当前专利权人地址: Nycoveien 1-2 0401 Oslo 4 NO
- 代理机构: Cockbain, Julian, Dr.
- 优先权: GB19940019203 19940923
- 国际公布: WO1996009282 19960328
- 主分类号: A61K49
- IPC分类号: A61K49 ; C07C33 ; C07C43 ; C07C49 ; C07C69 ; C07C233 ; C07C235 ; C07C237 ; C07C275 ; C07C307 ; C07C311 ; C07C317
摘要:
The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula (I), wherein n is 0 or 1, and where n is 1 each C6R5 moiety may be the same or different; each group R is a hydrogen atom, an iodine atom or a hydrophilic moiety M or M1, two or three non-adjacent R groups in each C6R5 moiety being iodine and at least one, and preferably two or three, R groups in each C6R5 moiety being M or M1 moieties; X denotes a bond or a group providing a 1 to 7 atom chain linking two C6R5 moieties or, where n is 0, X denotes a group R; each M independently is a non-ionic hydrophilic moiety; and each M1 independently represents a C1-4alkyl group substituted by at least one hydroxyl group and optionally linked to the phenyl ring via a carbonyl, sulphone or sulphoxide group, at least one R group being an M1 moiety; with the proviso that where n is zero either at least one M1 group other than a hydroxymethyl or 1,2-dihydroxyethyl group is present or then if one hydroxymethyl or 1,2-dihydroxyethyl M1 group is present at least one nitrogen-attached or hydroxylated-C3-4 alkyl moiety-containing M group is also present and isomers thereof.
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