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11 条记录 (耗时 0.013 秒)

    IODINATED X-RAY-CONTRAST MEDIA
    3.
    发明授权
    IODINATED X-RAY-CONTRAST MEDIA 失效
    碘化X射线造影剂

    公开(公告)号：EP0782565B1

    公开(公告)日：1999-04-07

    申请号：EP95932108.4

    申请日：1995-09-22

    申请人： NYCOMED IMAGING AS

    发明人： RYDBECK, Anna ,  ALMEN, Torsten ,  THANING, Mikkel ,  ANDERSSON, Sven ,  WISTRAND, Lars-Göran ,  GOLMAN, Klaes

    IPC分类号： C07C275/42 ,  C07C237/46 ,  C07C235/16 ,  A61K49/04

    CPC分类号： C07C237/46 ,  A61K49/0433 ,  C07C233/25 ,  C07C235/16 ,  C07C275/42

    摘要： The invention provides iodinated bis phenyl compounds, useful as X-ray contrast agents, of formula (I) (wherein each C6R5 moiety may be the same or different; each R denotes a hydrogen or iodine atom or a group M, two or three non-adjacent R groups on each C6R5 moiety denoting iodine atoms and one, two or three R groups on each C6R5 moiety denoting M groups; X denotes a group providing a 1, 2 or 3 atom chain linking the two C6R5 groups, preferably where X is or contains in the bridging chain a carbonyloxy group each C6R5 group being a triodophenyl group or a group in which each R is other than hydrogen; and each M is independently a non-ionic hydrophilic moiety, M preferably being a non-ionic hydrophilic moiety comprising a monohydroxy- or polyhydroxy-alkyl group) and isomers, especially stereoisomers and rotamers, thereof.

    IODINATED X-RAY-CONTRAST MEDIA
    4.
    发明公开
    IODINATED X-RAY-CONTRAST MEDIA 失效
    碘化的X射线对比介质

    公开(公告)号：EP0782565A1

    公开(公告)日：1997-07-09

    申请号：EP95932108.0

    申请日：1995-09-22

    申请人： NYCOMED IMAGING AS

    发明人： RYDBECK, Anna ,  ALMEN, Torsten ,  THANING, Mikkel ,  ANDERSSON, Sven ,  WISTRAND, Lars-Göran ,  GOLMAN, Klaes

    IPC分类号： A61K49 ,  C07C33 ,  C07C43 ,  C07C49 ,  C07C69 ,  C07C233 ,  C07C235 ,  C07C237 ,  C07C275 ,  C07C307 ,  C07C311 ,  C07C317

    CPC分类号： C07C237/46 ,  A61K49/0433 ,  C07C233/25 ,  C07C235/16 ,  C07C275/42

    摘要： The invention provides iodinated bis phenyl compounds, useful as X-ray contrast agents, of formula (I) (wherein each C6R5 moiety may be the same or different; each R denotes a hydrogen or iodine atom or a group M, two or three non-adjacent R groups on each C6R5 moiety denoting iodine atoms and one, two or three R groups on each C6R5 moiety denoting M groups; X denotes a group providing a 1, 2 or 3 atom chain linking the two C6R5 groups, preferably where X is or contains in the bridging chain a carbonyloxy group each C6R5 group being a triodophenyl group or a group in which each R is other than hydrogen; and each M is independently a non-ionic hydrophilic moiety, M preferably being a non-ionic hydrophilic moiety comprising a monohydroxy- or polyhydroxy-alkyl group) and isomers, especially stereoisomers and rotamers, thereof.

    摘要翻译： 本发明提供了可用作式（I）的X射线造影剂的碘化双苯基化合物（其中每个C 6 R 5部分可以相同或不同;每个R表示氢或碘原子或M组，两个或三个非 在每个C 6 R 5部分上的相邻R基团表示碘原子和每个C 6 R 5部分上的一个，两个或三个R基团表示M基团; X表示提供连接两个C 6 R 5基团的1,2或3个原子链的基团，优选其中X是 或者在桥连链中含有羰氧基，每个C 6 R 5基团是三联苯基或其中每个R不是氢的基团;并且每个M独立地为非离子型亲水部分，M优选为非离子型亲水部分， 单羟基 - 或多羟基 - 烷基）和异构体，特别是其立体异构体和旋转异构体。

    CONTRAST MEDIA
    6.
    发明公开
    CONTRAST MEDIA 有权
    造影剂

    公开(公告)号：EP1175392A1

    公开(公告)日：2002-01-30

    申请号：EP00927478.8

    申请日：2000-04-28

    申请人： NYCOMED IMAGING AS

    发明人： EK, Fredrik ,  ALMEN, Torsten

    IPC分类号： C07C237/20 ,  C07C237/22 ,  C07C237/46 ,  C07C235/16 ,  A61K49/04

    CPC分类号： A61K49/0433 ,  C07C235/16 ,  C07C237/20 ,  C07C237/22 ,  C07C237/46

    摘要： The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents of formula (I) wherein n is 0 or 1, and where n is 1 each C6R5 moiety may be the same or different; X denotes a bond or a group providing a 1 to 7 atom chain linking two C6R5 moieties or, where n is 0, X denotes a group R; each group R is a hydrogen atom, an iodine atom or a hydrophilic moiety M or M1, two or three non-adjacent R groups in each C6R5 moiety being iodine and at least one R group in each C6R5 moiety being an M or M1 moiety; each M which may be the same or different, is a non-ionic hydrophilic moiety; and each M1 independently represents a -CHOHCON (R1)2 group wherein each R1, which may be the same or different, is a hydrogen atom, an OH group or a C1-6 alkoxy or optionally hydroxylated C1-5 alkyl group; at least one R group in the molecule being an M1 moiety; and isomers thereof.

    HETEROCYCLIC CHELATING AGENTS
    8.
    发明授权
    HETEROCYCLIC CHELATING AGENTS 失效
    杂环螯合ACTIVE。

    公开(公告)号：EP0452392B1

    公开(公告)日：1995-04-12

    申请号：EP90901813.7

    申请日：1990-01-15

    申请人： NYCOMED IMAGING AS

    发明人： ALMEN, Torsten ,  BERG, Arne ,  DUGSTAD, Harald ,  KLAVENESS, Jo ,  KRAUTWURST, Klaus, Dieter ,  RONGVED, Pal

    IPC分类号： C07D211/46 ,  A61K49/00 ,  C07D265/30 ,  C07D207/12 ,  C07D241/04 ,  C07D279/12 ,  A61K51/00 ,  A61K49/04

    CPC分类号： C07D211/56 ,  A61K47/54 ,  A61K47/547 ,  A61K49/06 ,  A61K51/0478 ,  A61K51/0482 ,  A61K2121/00 ,  A61K2123/00 ,  C07D207/14 ,  C07D241/04 ,  C07D265/30 ,  C07D279/12 ,  C07F3/003 ,  C07F5/003 ,  C07F9/94 ,  C07F13/005 ,  Y10S514/836 ,  Y10T436/24

    摘要： There are provided heterocyclic chelating agents particularly useful for the preparation of diagnostic and therapeutic agents for magnetic resonance imaging, scintigraphy, ultrasound imaging, radiotherapy and heavy metal detoxification, said agents being compounds of formula (I) (wherein X represents a bond, an oxygen or sulphur atom or a group of formula CHR?1 or NR3¿; each R1 which may be the same or different represents a hydrogen atom, a group of formula OR?3 or NR3R3¿ or an alkyl or alkoxyalkyl group optionally substituted by a hydroxyl group or by a group of formula NR3R3 or CONR3R3; each R2 which may be the same or different represents a hydrogen atom or an alkyl or alkoxy group optionally substituted by a hydroxyl or alkoxy group; each R3 which may be the same or different represents a hydrogen atom, an optionally hydroxylated alkyl group or a group of formula CH¿2?Y; Y represents a group of formula COZ, CON(OH)R?4, POZ¿2 or SO2Z; Z represents a group of formula OR?4, Nr4R4¿ or (II) where each R11 which may be the same or different is a hydrogen atom, a hydroxyl group or an optionally hydroxylated alkyl group, s is 0, 1 or 2, and W is a group CHR?11, NR11¿ or an oxygen atom; and each R4 which may be the same or different represents a hydrogen atom or an optionally mono- or poly hydroxylated alkyl, alkoxyalkyl or polyalkoxyalkyl group; with the provisos that where s is 0 then W is a CHR11 group and that where X represents a bond or a group CHR1 at least one group R1 or R2 represents other than a hydrogen atom or an unsubstituted alkyl group) and chelate complexes and salts thereof.