发明公开
- 专利标题： CONTRAST AGENT
- 专利标题（中）： 对比剂
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申请号： EP94927724.0申请日： 1994-09-27
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公开(公告)号： EP0783325A1公开(公告)日： 1997-07-16
- 发明人: FAHLVIK, Anne, Kjersti , NÄVESTAD, Anne , GUNDERSEN, Helge , STRANDE, Per , KLAVENESS, Jo , JACOBSEN, Anne
- 申请人： NYCOMED IMAGING AS , COCKBAIN, Julian Roderick Michaelson
- 申请人地址： Nycoveien 1-2 0401 Oslo 4 NO
- 专利权人： NYCOMED IMAGING AS,COCKBAIN, Julian Roderick Michaelson
- 当前专利权人： NYCOMED IMAGING AS,COCKBAIN, Julian Roderick Michaelson
- 当前专利权人地址： Nycoveien 1-2 0401 Oslo 4 NO
- 代理机构： Cockbain, Julian, Dr., et al
- 国际公布： WO1996009840 19960404
- 主分类号： A61K
- IPC分类号： A61K ; A61K49 ; A61K51
摘要：
The invention relates to particulate contrast agents, especially contrast agents for MR imaging, having a metal oxide, preferably superparamagnetic iron oxide core provided with a low coating density of a polyelectrolyte coating agent selected from structural polysaccharides and synthetic polymers, especially polyaminoacids. Unlike conventional coated particulates, the new particles have reduced or no effect on cardiovascular parameters, platelet depletion, complement activation and blood coagulation.
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