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公开(公告)号：EP0783325A1
公开(公告)日：1997-07-16
申请号：EP94927724.0
申请日：1994-09-27
发明人： FAHLVIK, Anne, Kjersti , NÄVESTAD, Anne , GUNDERSEN, Helge , STRANDE, Per , KLAVENESS, Jo , JACOBSEN, Anne
CPC分类号： A61K51/1258 , A61K49/1854 , A61K49/1863 , A61K49/1872
摘要： The invention relates to particulate contrast agents, especially contrast agents for MR imaging, having a metal oxide, preferably superparamagnetic iron oxide core provided with a low coating density of a polyelectrolyte coating agent selected from structural polysaccharides and synthetic polymers, especially polyaminoacids. Unlike conventional coated particulates, the new particles have reduced or no effect on cardiovascular parameters, platelet depletion, complement activation and blood coagulation.
摘要翻译： 本发明涉及颗粒造影剂，尤其是用于MR成像的造影剂，其具有金属氧化物，优选超顺磁性氧化铁芯，其具有低涂覆密度的选自结构多糖和合成聚合物，特别是聚氨基酸的聚电解质涂覆剂。 与传统的包衣颗粒不同，新颗粒对心血管参数，血小板减少，补体活化和血液凝固的影响降低或没有影响。
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公开(公告)号：EP0930897A2
公开(公告)日：1999-07-28
申请号：EP97934621.0
申请日：1997-07-30
申请人： NYCOMED IMAGING AS
发明人： PETTERSSON, Göran , GOLMAN, Klaes , JACOBSEN, Anne , DEG RDSTUEN, Liv-Ingrid , FAHLVIK, Anne, Kjersti
IPC分类号： A61K49
摘要： The invention provides the use of a physiologically tolerable manganese compound or a salt thereof, substantially free from hydrophilic polymer components containing a significant amount of a Mn2+- chelating unit, in the manufacture of an enterally, e.g. orally or rectally, administrable MRI contrast medium composition for use in a method of imaging of a human or non-human animal body which has fasted for a period of at least 6, preferably at least 10, more preferably at least 12 hours before enteral administration of said composition. It has been found that diagnostically effective levels of uptake of orally or rectally administered manganese may be achieved using this method.
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公开(公告)号：EP0783325B1
公开(公告)日：1999-12-01
申请号：EP94927724.8
申请日：1994-09-27
申请人： NYCOMED IMAGING AS
发明人： FAHLVIK, Anne Kjersti , NAEVESTAD, Anne , GUNDERSEN, Helge , STRANDE, Per , KLAVENESS, Jo , JACOBSEN, Anne
CPC分类号： A61K51/1258 , A61K49/1854 , A61K49/1863 , A61K49/1872
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公开(公告)号：EP0941127A2
公开(公告)日：1999-09-15
申请号：EP97933806.0
申请日：1997-07-30
申请人： NYCOMED IMAGING AS
发明人： PETTERSSON, Göran , GOLMAN, Klaes , JACOBSEN, Anne , OEDEGARDSTUEN, Liv-Ingrid , FAHLVIK, Anne, Kjersti
IPC分类号： A61K49
CPC分类号： A61K49/103 , A61K49/1818 , A61K49/1887 , Y10S514/836
摘要： The invention provides the use of a physiologically tolerable manganese compound or a salt thereof, in combination with a second contrast agent, preferably one which is retained within the gut and there exhibits a negative contrast effect, in the manufacture of an enterally, e.g. orally or rectally, administrable MRI contrast medium composition for use in a method of functional imaging of the gastrointestinal tract of a human or non-human animal body. This imaging technique has surprisingly been found to provide clear delineation of those portions of the gut wall in which manganese uptake is occurring, thereby enabling not only the detection of tumors in the gut, but also the identification of regions of the gut which may be functioning abnormally.
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