发明公开
EP0809499A1 CERTAIN 1,4,5-TRI-SUBSTITUTED IMIDAZOLE COMPOUNDS USEFUL AS CYTOKINE
失效
某些1,4,5-三取代的IMIDAZOLEVERBINDUNGEN FOR USE AS细胞因子
- 专利标题： CERTAIN 1,4,5-TRI-SUBSTITUTED IMIDAZOLE COMPOUNDS USEFUL AS CYTOKINE
- 专利标题（中）： 某些1,4,5-三取代的IMIDAZOLEVERBINDUNGEN FOR USE AS细胞因子
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申请号： EP96902151.0申请日： 1996-01-11
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公开(公告)号： EP0809499A1公开(公告)日： 1997-12-03
- 发明人: ADAMS, Jerry, Leroy , GALLAGHER, Timothy, F. , GARIGIPATI, Ravi, Shanker , BOEHM, Jeffrey, Charles , SISKO, Joseph , PENG, Zhi-Qiang , LEE, John, Cheung-Lun
- 申请人： SMITHKLINE BEECHAM CORPORATION
- 申请人地址： Corporate Intellectual Property, UW2220, P.O. Box 1539, 709 Swedeland Road King of Prussia, PA 19406-0939 US
- 专利权人： SMITHKLINE BEECHAM CORPORATION
- 当前专利权人： SMITHKLINE BEECHAM CORPORATION
- 当前专利权人地址： Corporate Intellectual Property, UW2220, P.O. Box 1539, 709 Swedeland Road King of Prussia, PA 19406-0939 US
- 代理机构： Connell, Anthony Christopher
- 优先权： US19950369964 19950109; US19950472366 19950607
- 国际公布： WO1996021452 19960718
- 主分类号： C07C
- IPC分类号： C07C ; A61K8 ; A61K31 ; A61P1 ; A61P3 ; A61P7 ; A61P9 ; A61P11 ; A61P17 ; A61P19 ; A61P21 ; A61P25 ; A61P29 ; A61P31 ; A61P35 ; A61P37 ; A61P39 ; A61P43 ; A61Q1 ; A61Q19 ; C07B61 ; C07C231 ; C07C233 ; C07C311 ; C07C315 ; C07C317 ; C07C319 ; C07C323 ; C07D213 ; C07D215 ; C07D233 ; C07D239 ; C07D295 ; C07D401 ; C07D403 ; C07D405 ; C07D409 ; C07D413
摘要：
This invention relates to certain 5-(optionally substituted aryl or heteroaryl)-4-(optionally substituted heteroaryl)-1-(optionally substituted heterocyclyl or heterocyclylalkyl) or 1- optionally substituted alkyl or alkenyl -imidazoles and derivatives thereof. Synthetic processes for the preparation of said tri-substituted imidazoles is described. The aforementioned imidazoles are useful for treating cytokine mediated diseases. The compounds of the invention are incorporated into pharmaceutical compositions for use in treating cytokine related diseases.
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