发明公开
- 专利标题： NOVEL PROTEIN AND METHODS FOR THE PRODUCTION OF THE SAME
- 专利标题（中）： 使用ZU DESSEN GEWINNUNG消灭蛋白质
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申请号： EP96902484申请日： 1996-02-20
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公开(公告)号： EP0816380A4公开(公告)日： 1998-11-18
- 发明人: GOTO MASAAKI , TSUDA EISUKE , MOCHIZUKI SHIN ICHI , YANO KAZUKI , KOBAYASHI FUMIE , SHIMA NOBUYUKI , YASUDA HISATAKA , NAKAGAWA NOBUAKI , MORINAGA TOMONORI , UEDA MASATSUGU , HIGASHIO KANJI
- 申请人： SNOW BRAND MILK PROD CO LTD
- 专利权人： SNOW BRAND MILK PROD CO LTD
- 当前专利权人： SNOW BRAND MILK PROD CO LTD
- 优先权： JP5497795 1995-02-20; JP20750895 1995-07-21
- 主分类号： C07K14/52
- IPC分类号： C07K14/52 ; A61K38/19 ; A61P19/10 ; C07K14/705 ; C07K16/24 ; C12N1/21 ; C12N5/08 ; C12N15/12 ; C12N15/19 ; C12P21/02 ; C12P21/08 ; C12N5/10 ; C12N5/20 ; C12N15/06 ; G01N33/577
摘要：
A novel protein having the activity of suppressing the differentiation and/or maturation of osteoclasts and methods of the production of the same. This protein is produced from human fetal pulmonary fibroblasts and has a molecular weight of about 60 KD under reductive conditions or about 120 KD under nonreductive conditions. It can be isolated and purified from the culture medium of the above-mentioned cells. Alternatively, it can be produced by genetic engineering techniques. The invention also provides a cDNA for the genetic engineering production of the protein, an antibody showing an affinity specifically for the protein, and a method for assaying the protein with the use of this antibody.
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