发明公开
- 专利标题： AMINOTHIAZOLE DERIVATIVES, DRUG CONTAINING THE SAME AND INTERMEDIATE IN THE PRODUCTION OF THE COMPOUNDS
- 专利标题（中）： 噻唑，含药及中间体在制造这些化合物
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申请号： EP96915167.9申请日： 1996-05-16
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公开(公告)号： EP0870765A1公开(公告)日： 1998-10-14
- 发明人: NAGASAWA, Masaaki, Zeria Pharmaceutical Co., Ltd. , MURATA, Masakazu, Zeria Pharmaceutical Co., Ltd. , NISHIOKA, Hiroyasu, Zeria Pharmaceutical Co., Ltd. , KURIMOTO, Tadashi, Zeria Pharmaceutical Co., Ltd. , UEKI, Shigeru, Zeria Pharmaceutical Co., Ltd. , KITAGAWA, Osamu, Zeria Pharmaceutical Co., Ltd.
- 申请人： ZERIA PHARMACEUTICAL CO., LTD.
- 申请人地址： 10-11, Nihonbashi Kobuna-cho Chuo-ku, Tokyo 103 JP
- 专利权人： ZERIA PHARMACEUTICAL CO., LTD.
- 当前专利权人： ZERIA PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： 10-11, Nihonbashi Kobuna-cho Chuo-ku, Tokyo 103 JP
- 代理机构： Wächtershäuser, Günter, Prof. Dr.
- 优先权： JP142399/95 19950518
- 国际公布： WO9636619 19961121
- 主分类号： C07D277/56
- IPC分类号： C07D277/56 ; C07D417/12 ; A61K31/425 ; A61K31/44 ; A61K31/445 ; A61K31/495
摘要：
The present invention relates to an aminothiazole derivative represented by the following formula (I):
wherein R 1 , R 2 and R 3 each independently represents a hydrogen atom, a hydroxy group, a lower alkyl group, a lower alkoxy group or the like; R 4 represents a hydrogen atom or a lower alkyl group; R 5 represents a hydrogen atom, a halogen atom or a lower alkyl group; m stands for an integer of 0 to 4, A represents a substituted amino group, a substituted imino group, a heterocyclic group or the like; and B stands for an imino group or an oxygen atom, a medicament containing it and an intermediate for the preparation of said compound. The compound has strong restoration effects on dysmotility in the gastrointestinal tract and at the same time has high safety so that it is useful as an excellent gastroprokinetic.
wherein R 1 , R 2 and R 3 each independently represents a hydrogen atom, a hydroxy group, a lower alkyl group, a lower alkoxy group or the like; R 4 represents a hydrogen atom or a lower alkyl group; R 5 represents a hydrogen atom, a halogen atom or a lower alkyl group; m stands for an integer of 0 to 4, A represents a substituted amino group, a substituted imino group, a heterocyclic group or the like; and B stands for an imino group or an oxygen atom, a medicament containing it and an intermediate for the preparation of said compound. The compound has strong restoration effects on dysmotility in the gastrointestinal tract and at the same time has high safety so that it is useful as an excellent gastroprokinetic.
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