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1.发明授权
公开(公告)号：EP0870765B1
公开(公告)日：2003-11-19
申请号：EP96915167.9
申请日：1996-05-16
发明人： NAGASAWA, Masaaki, Zeria Pharmaceutical Co., Ltd. , MURATA, Masakazu, Zeria Pharmaceutical Co., Ltd. , NISHIOKA, Hiroyasu, Zeria Pharmaceutical Co., Ltd. , KURIMOTO, Tadashi, Zeria Pharmaceutical Co., Ltd. , UEKI, Shigeru, Zeria Pharmaceutical Co., Ltd. , KITAGAWA, Osamu, Zeria Pharmaceutical Co., Ltd.
IPC分类号： C07D277/56 , C07D417/12 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/495
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/56 , C07D417/12
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2.发明授权PHARMACEUTICAL COMPOSITIONS CONTAINING AMINOTHIAZOLE DERIVATIVES FOR THE TREATMENT OF COLONIC MOTOR DYSFUNCTIONS 有权药物组合物含氨基噻唑衍生物的肠道DICK电机障碍的治疗
公开(公告)号：EP1315488B1
公开(公告)日：2006-10-25
申请号：EP01930024.3
申请日：2001-05-10
发明人： UEKI, Shigeru, c/o Zeria Pharmaceutical Co., Ltd. , HORI, Yuko, c/o Zeria Pharmaceutical Co., Ltd. , MATSUNAGA, Yugo, c/o Zeria Pharmeutical Co., Ltd. , NAGASAWA, Masaaki, Zeria Pharmaceutical Co., Ltd. , NISHIOKA, Hiroyasu, Zeria Pharmaceutical Co., Ltd. , MURATA, Masakazu, c/o Zeria Pharmaceutical Co.,Ltd
IPC分类号： A61K31/426 , A61P1/00
CPC分类号： A61K31/426 , A61K31/381
摘要： Remedies effective for the improvement of colonic motor dysfunction such as irritable bowel syndrome, constipation or intestinal atony without causing side effects on the central nerve system. These colonic motor dysfunction remedies comprise, as active ingredients, aminothiazole derivatives represented by the following formula (I) or a salt or hydrate thereof: wherein R , R and R may be the same or different and each independently represent a hydrogen atom or a hydroxyl, lower alkyl, lower alkoxy, amino, nitro or cyano group, R and R may be the same or different and each independently represent a hydrogen atom or a lower alkyl group, and n stands for an integer of from 2 to 4.
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3.发明公开
公开(公告)号：EP0870765A1
公开(公告)日：1998-10-14
申请号：EP96915167.9
申请日：1996-05-16
发明人： NAGASAWA, Masaaki, Zeria Pharmaceutical Co., Ltd. , MURATA, Masakazu, Zeria Pharmaceutical Co., Ltd. , NISHIOKA, Hiroyasu, Zeria Pharmaceutical Co., Ltd. , KURIMOTO, Tadashi, Zeria Pharmaceutical Co., Ltd. , UEKI, Shigeru, Zeria Pharmaceutical Co., Ltd. , KITAGAWA, Osamu, Zeria Pharmaceutical Co., Ltd.
IPC分类号： C07D277/56 , C07D417/12 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/495
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/56 , C07D417/12
摘要： The present invention relates to an aminothiazole derivative represented by the following formula (I):
wherein R 1 , R 2 and R 3 each independently represents a hydrogen atom, a hydroxy group, a lower alkyl group, a lower alkoxy group or the like; R 4 represents a hydrogen atom or a lower alkyl group; R 5 represents a hydrogen atom, a halogen atom or a lower alkyl group; m stands for an integer of 0 to 4, A represents a substituted amino group, a substituted imino group, a heterocyclic group or the like; and B stands for an imino group or an oxygen atom, a medicament containing it and an intermediate for the preparation of said compound. The compound has strong restoration effects on dysmotility in the gastrointestinal tract and at the same time has high safety so that it is useful as an excellent gastroprokinetic.摘要翻译： 本发明涉及在氨基噻唑衍生物由下式（I）表示：
worin - [R <1>，R <2>和R <3>每个unabhängigdarstellt为氢原子，羟基，低级烷基 ，低级烷氧基等; [R <4> darstellt一个氢原子或一个低级烷基; [R <5>代表氢原子，卤原子或低级烷基; m表示在0至4的整数，A darstellt一个substituiertem氨基，substituiertem亚氨基，杂环基等; 和B代表在亚氨基或氧原子，药物含有它和中间体，所述化合物的制备。 该化合物对胃肠道运动功能障碍恢复强劲效果，同时具有很高的安全性，从而做到了是作为一个优秀的gastroprokinetic有用。
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