发明授权
EP0885192B1 DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN- ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVE, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS
失效
二氢吡啶，BENZOPYRANON-和TRIAZOLOCHINAZOLIN衍生物，其制备和用途AS腺苷受体拮抗剂
- 专利标题： DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN- ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVE, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS
- 专利标题（中）： 二氢吡啶，BENZOPYRANON-和TRIAZOLOCHINAZOLIN衍生物，其制备和用途AS腺苷受体拮抗剂
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申请号： EP97905627.2申请日： 1997-01-29
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公开(公告)号： EP0885192B1公开(公告)日： 2012-03-07
- 发明人: JACOBSON, Kenneth, A. , JIANG, Ji-Long , KIM, Yong-Chul , KARTON, Yishai , VAN RHEE, Albert, M.
- 申请人： The United States of America, Represented by the Secretary, Department of Health and Human Services
- 申请人地址： National Institutes of Health Office of Technology Transfer Box OTT Bethesda, MO 20892-9902 US
- 专利权人： The United States of America, Represented by the Secretary, Department of Health and Human Services
- 当前专利权人： The United States of America, Represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： National Institutes of Health Office of Technology Transfer Box OTT Bethesda, MO 20892-9902 US
- 代理机构： Nicholls, Kathryn Margaret
- 优先权： US10737P 19960129; US21191P 19960703
- 国际公布： WO1997027177 19970731
- 主分类号： C07D211/90
- IPC分类号： C07D211/90
摘要：
The present invention provides certain novel compounds, compositions, and a method of treating a mammal by blocking its adenosine receptors comprising administering at least one compound of the present invention. Examples of the present inventive compounds include certain flavonoids of formulae (I) and (II), wherein R1 to R4 are as defined in the description, and M is -CH(OH)-CH(R2)- or -C(OH)= C(R2)- and R1, R2 are as defined in the description; or dihydropyridines of formula (III), wherein R2 to R6 are as defined in the description; or pyridines of formula (IV), wherein R2 to R6 are as defined in the description, or triazoloquinazolines of formula (V), wherein R1 and R2 are as defined in the description; and their derivatives, or pharmaceutically acceptable salts thereof.
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