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1.发明授权DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN- ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVE, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS 失效二氢吡啶，BENZOPYRANON-和TRIAZOLOCHINAZOLIN衍生物，其制备和用途AS腺苷受体拮抗剂
公开(公告)号：EP0885192B1
公开(公告)日：2012-03-07
申请号：EP97905627.2
申请日：1997-01-29
申请人： The United States of America, Represented by the Secretary, Department of Health and Human Services
发明人： JACOBSON, Kenneth, A. , JIANG, Ji-Long , KIM, Yong-Chul , KARTON, Yishai , VAN RHEE, Albert, M.
IPC分类号： C07D211/90
CPC分类号： C07D401/04 , C07D211/90 , C07D311/22 , C07D311/30 , C07D311/32 , C07D317/70 , C07D405/04 , C07D409/04 , C07D487/04 , C07D493/04 , C07F7/0812
摘要： The present invention provides certain novel compounds, compositions, and a method of treating a mammal by blocking its adenosine receptors comprising administering at least one compound of the present invention. Examples of the present inventive compounds include certain flavonoids of formulae (I) and (II), wherein R1 to R4 are as defined in the description, and M is -CH(OH)-CH(R2)- or -C(OH)= C(R2)- and R1, R2 are as defined in the description; or dihydropyridines of formula (III), wherein R2 to R6 are as defined in the description; or pyridines of formula (IV), wherein R2 to R6 are as defined in the description, or triazoloquinazolines of formula (V), wherein R1 and R2 are as defined in the description; and their derivatives, or pharmaceutically acceptable salts thereof.
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2.发明授权DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN- ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVE, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS 失效二氢吡啶，BENZOPYRANON-和TRIAZOLOCHINAZOLIN衍生物，其制备和用途AS腺苷受体拮抗剂
公开(公告)号：EP0885192B8
公开(公告)日：2012-05-16
申请号：EP97905627.2
申请日：1997-01-29
申请人： The United States of America, Represented by the Secretary, Department of Health and Human Services
IPC分类号： C07D211/90
CPC分类号： C07D401/04 , C07D211/90 , C07D311/22 , C07D311/30 , C07D311/32 , C07D317/70 , C07D405/04 , C07D409/04 , C07D487/04 , C07D493/04 , C07F7/0812
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