公开(公告)号：EP3054987B1

公开(公告)日：2019-10-09

申请号：EP14789480.2

申请日：2014-10-13

申请人： The United States of America, represented by the Secretary, Department of Health and Human Services ,  Biomed Valley Discoveries, Inc.

发明人： DIMITROV, Dimiter ,  ZHU, Zhongyu ,  ST. CROIX, Brad ,  ZUDAIRE, Enrique ,  SAHA, Saurabh ,  ZHANG, Xiaoyan, Michelle ,  DECRESCENZO, Gary ,  WELSCH, Dean

IPC分类号： A61K47/68 ,  A61P35/00 ,  C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  A61K9/00 ,  A61K45/06 ,  A61K49/16 ,  C07K14/725 ,  C07K16/30 ,  G01N33/574 ,  C07H21/04 ,  C12N15/09 ,  C12N15/63 ,  A61P31/04

公开(公告)号：EP2069308B1

公开(公告)日：2017-03-29

申请号：EP07842310.0

申请日：2007-09-12

申请人： Government of the United States of America, Represented by the Secretary, Department of Health and Human Services

发明人： TARASOVA, Nadya I. ,  DYBA, Marcin

IPC分类号： C07D221/18 ,  C07D401/12 ,  C07K7/06 ,  A61K31/473 ,  A61P35/00

CPC分类号： C07D221/18 ,  C07D401/12

公开(公告)号：EP1687322B1

公开(公告)日：2017-02-08

申请号：EP04811370.8

申请日：2004-11-12

申请人： The Government of the United States of America, represented by the Secretary, Department of Health and Human Services

发明人： PANICALI, Dennis, L. ,  MAZZARA, Gail, P. ,  GRITZ, Linda, R. ,  SCHLOM, Jeffrey ,  HODGE, James, W. ,  TSANG, Kwong-Yok

IPC分类号： C07H21/02 ,  C12N15/00 ,  A61K48/00 ,  A61K39/00 ,  C12N7/00 ,  C12N15/86

CPC分类号： C12N15/86 ,  A61K39/0011 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55516 ,  C12N7/00 ,  C12N2710/24043 ,  C12N2710/24071 ,  C12N2710/24143 ,  C12N2710/24171

公开(公告)号：EP2772225A1

公开(公告)日：2014-09-03

申请号：EP14169484.4

申请日：2002-03-14

申请人： THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Robinson, Michael R. ,  Csaky, Karl, G. ,  Nussenblatt, Robert, B. ,  Smith, Janine, A. ,  Yuan, Peng ,  Sung, Cynthia ,  Fronheiser, Matthew, P. ,  Kim, Hyun, C.

IPC分类号： A61F2/00 ,  A61K9/00

CPC分类号： A61K9/0051 ,  A61F9/0017 ,  A61F9/00781 ,  A61K9/5026 ,  A61K9/5031 ,  A61K9/5047 ,  A61K9/5089 ,  A61K31/565 ,  A61K31/58 ,  A61K38/13 ,  B29D11/023 ,  B29K2083/00 ,  B29K2827/18 ,  Y10S425/808

摘要： The present invention relates to an intraocular reservoir implant (121, 123), characterized by a first therapeutic agent reservoir subassembly (121, 121A) including an inner core (121") including a therapeutic agent for the eye (101) covered by and substantially radially centered within a polymeric layer (121') including silicone material permeable to the therapeutic agent, and an ocular attachment means (123) affixed to the polymeric layer of the subassembly.

摘要翻译： 本发明涉及到在通过第一治疗剂贮存器子组件（121，121A）包括在内芯（121“），其特征眼内植入物水库（121，123）包括对眼睛（101）的治疗剂覆盖并基本上 包括硅树脂材料可渗透的治疗剂，以及固定到子组件的聚合物层眼附接装置（123）的聚合物层（121“）内的径向的中心。

公开(公告)号：EP2431388A1

公开(公告)日：2012-03-21

申请号：EP11179413.7

申请日：2007-10-30

申请人： Government of the United States of America, Represented by the Secretary, Department of Health and Human Services

发明人： Tarasova, Nadya ,  Dean, Michael ,  Lou, Hong

IPC分类号： C07K14/705

CPC分类号： C07K14/705

摘要： Disclosed is an isolated or purified polypeptide or peptidomimetic comprising an amino acid sequence of a portion of a Smoothened (SMO) protein, wherein the portion comprises an amino acid sequence of any of the intracellular loops of the SMO protein, a functional fragment thereof, or a functional variant of either the portion or the functional fragment, wherein the functional fragment comprises at least 7 contiguous amino acids of the intracellular loops, and wherein the functional fragment or functional variant inhibits proliferation of a diseased cell, or a fatty acid derivative thereof. Related conjugates, nucleic acids, recombinant expression vectors, host cells, and pharmaceutical compositions are further provided. Methods of inhibiting proliferation of a diseased cell, treating or preventing cancer, treating a neoplasm or psoriasis, and inhibiting the expression of genes involved in the Hedgehog signaling pathway, thereby inhibiting the Hedgehog signaling pathway, are furthermore provided by the invention.

摘要翻译： 公开了一种分离或纯化的多肽或肽模拟物，其包含Smoothened（SMO）蛋白的一部分的氨基酸序列，其中该部分包含SMO蛋白的任何细胞内环的氨基酸序列，其功能片段或 该部分或功能性片段的功能变体，其中功能性片段包含细胞内环的至少7个连续的氨基酸，并且其中功能片段或功能性变体抑制病变细胞或其脂肪酸衍生物的增殖。 进一步提供相关缀合物，核酸，重组表达载体，宿主细胞和药物组合物。 通过本发明进一步提供了抑制病变细胞增殖，治疗或预防癌症，治疗肿瘤或银屑病以及抑制涉及Hedgehog信号传导途径的基因的表达从而抑制Hedgehog信号通路的方法。

公开(公告)号：EP1809321B1

公开(公告)日：2012-03-14

申请号：EP05858553.0

申请日：2005-10-07

申请人： Government of the United States of America, Represented by the Secretary, Department of Health and Human Services

发明人： MORGAN, Richard, A. ,  ROSENBERG, Steven, A. ,  HSU, Cary

IPC分类号： C12N5/0783

CPC分类号： C12N5/0636 ,  A61K2039/5156 ,  A61K2039/5158 ,  A61K2039/55527

摘要： The invention provides for compositions, e.g., pharmaceutical compositions, comprising a T lymphocyte, or a population thereof, expressing at least one recombinant polynucleotide encoding a cytokine that enhances T lymphocyte survival during the contraction phase of an immune response. The invention further provides an isolated T lymphocyte, or population thereof, expressing at least one recombinant polynucleotide encoding the cytokine, wherein the polynucleotide comprises a non-native coding sequence encoding the cytokine. Also provided is the use of such compositions and T lymphocytes, or populations thereof, for the treatment or prevention of a medical condition e.g., cancer. A method of preparing the a T lymphocyte with enhanced T cell survival is further provided herein.

公开(公告)号：EP0885192B1

公开(公告)日：2012-03-07

申请号：EP97905627.2

申请日：1997-01-29

申请人： The United States of America, Represented by the Secretary, Department of Health and Human Services

发明人： JACOBSON, Kenneth, A. ,  JIANG, Ji-Long ,  KIM, Yong-Chul ,  KARTON, Yishai ,  VAN RHEE, Albert, M.

IPC分类号： C07D211/90

CPC分类号： C07D401/04 ,  C07D211/90 ,  C07D311/22 ,  C07D311/30 ,  C07D311/32 ,  C07D317/70 ,  C07D405/04 ,  C07D409/04 ,  C07D487/04 ,  C07D493/04 ,  C07F7/0812

摘要： The present invention provides certain novel compounds, compositions, and a method of treating a mammal by blocking its adenosine receptors comprising administering at least one compound of the present invention. Examples of the present inventive compounds include certain flavonoids of formulae (I) and (II), wherein R1 to R4 are as defined in the description, and M is -CH(OH)-CH(R2)- or -C(OH)= C(R2)- and R1, R2 are as defined in the description; or dihydropyridines of formula (III), wherein R2 to R6 are as defined in the description; or pyridines of formula (IV), wherein R2 to R6 are as defined in the description, or triazoloquinazolines of formula (V), wherein R1 and R2 are as defined in the description; and their derivatives, or pharmaceutically acceptable salts thereof.

公开(公告)号：EP2368985A2

公开(公告)日：2011-09-28

申请号：EP10184784.6

申请日：2003-03-10

申请人： Emory University ,  The United States of America, represented by the Secretary, Department of Health and Human Services

发明人： Robinson, Harriet L. ,  Smith, James M. ,  Hua, Jian ,  Moss, Bernard

IPC分类号： C12N15/09 ,  A61K39/21

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/55511 ,  C07K14/005 ,  C12N15/70 ,  C12N15/85 ,  C12N15/86 ,  C12N2710/24143 ,  C12N2740/16022 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2830/00 ,  C12N2830/15 ,  C12N2830/42 ,  C12N2830/60

摘要： We have developed DNA and viral vectors that can be used, alone or in combination, as a vaccine against one HIV clade, subtype, or recombinant form of HIV or against multiple HIV clades, subtypes, or recombinant forms. Moreover, the vectors can encode a variety of antigens, which may be obtained from one clade or from two or more different clades, and the antigens selected and/or the manner in which the vectors are formulated ( e.g ., mixed) can be manipulated to generate a protective immune response against a variety of clades ( e.g ., the clades to which a patient is most likely to be exposed; with the proportions of the components of the vaccine tailored to the extent of the patient's risk to a particular clade or clades).

摘要翻译： 我们开发了可以单独使用或组合使用的DNA和病毒载体，作为针对一种HIV进化枝，亚型或重组形式的HIV或针对多种HIV进化枝，亚型或重组形式的疫苗。 此外，载体可以编码可以从一个进化枝或两个或多个不同进化枝获得的各种抗原，并且可以操纵选择的抗原和/或载体配制的方式（例如，混合） 产生针对各种分支（例如，患者最有可能暴露的进化枝）的保护性免疫应答;根据患者对特定进化枝的风险程度调整疫苗组分的比例， 分支）。

公开(公告)号：EP2339011A1

公开(公告)日：2011-06-29

申请号：EP11000126.0

申请日：2003-01-09

申请人： THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  Walter Reed Army Institute of Research

发明人： Pletnev, Alexander G. ,  Chanock, Robert M. ,  Murphy, Brian R. ,  Whitehead, Stephen S. ,  Blaney, Joseph E. Sr. ,  Putnak, Joseph R.

IPC分类号： C12N15/86 ,  C12N7/04 ,  A61K39/12 ,  C07K14/18

CPC分类号： A61K39/12 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24143 ,  C12N2770/24162 ,  C12Q1/6888 ,  Y02A50/386 ,  Y02A50/394

摘要： The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue 4 virus backbone for the production of immunogenic, live, attenuated West Nile virus vaccines.

摘要翻译： 本发明涉及一种减毒，建立在登革热病毒4骨干生产免疫原性，减毒活西尼罗河病毒疫苗免疫原性西尼罗河病毒嵌合体。

公开(公告)号：EP1355910B1

公开(公告)日：2011-03-09

申请号：EP02709145.3

申请日：2002-01-25

申请人： The United States of America, represented by the Secretary, Department of Health and Human Services

发明人： GUPTA, Shanker

IPC分类号： C07F5/02 ,  C07F5/04 ,  C07K5/078 ,  A61K38/05 ,  A61K31/69 ,  A61P35/00 ,  A61P29/00

CPC分类号： C07K5/0827 ,  A61K38/00 ,  C07F5/025 ,  C07F5/04 ,  C07K5/06191 ,  C07K7/02

摘要： The present invention provides stable compounds prepared from boronic acid and lyophilized compounds thereof of formula (1) in which Z?1 and Z2¿ are moieties derived from sugar. The invention also provides methods for preparing such compounds. Lyophilizing a mixture comprising a boronic acid compound and a moiety derived from sugar produces a stable composition that readily releases the boronic acid compound upon reconstitution in aqueous media.