发明授权
- 专利标题： PROCESS FOR THE PREPARATION OF CONTRAST AGENTS
- 专利标题（中）： 用于生产造影剂
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申请号： EP97937743.9申请日： 1997-08-29
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公开(公告)号： EP0923537B1公开(公告)日： 2001-10-31
- 发明人: GULBRANDSEN, Trygve , INGVOLDSTAD, Odd, Einar , HOLMAAS, Lars, Terje
- 申请人： NYCOMED IMAGING AS
- 申请人地址： Nycoveien 1-2 0401 Oslo 4 NO
- 专利权人： NYCOMED IMAGING AS
- 当前专利权人： NYCOMED IMAGING AS
- 当前专利权人地址： Nycoveien 1-2 0401 Oslo 4 NO
- 代理机构： Skailes, Humphrey John
- 优先权： GB9618055 19960829
- 国际公布： WO9808805 19980305
- 主分类号： C07C231/08
- IPC分类号： C07C231/08
摘要：
The invention provides a process for the preparation of an N-alkyl-acylamino-phenyl-carboxylic acid or carboxylic acid derivative by liquid phase acylation and subsequent N-alkylation of a corresponding amino-phenyl-carboxylic acid (or carboxylic acid derivative), the improvement comprising the addition of an alkylating agent to a solution containing the reaction products of said acylation, to effect said N-alkylation.
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