公开(公告)号：EP0923537A1

公开(公告)日：1999-06-23

申请号：EP97937743.0

申请日：1997-08-29

申请人： NYCOMED IMAGING AS

发明人： GULBRANDSEN, Trygve ,  INGVOLDSTAD, Odd, Einar ,  HOLMAAS, Lars, Terje

IPC分类号： A61K49 ,  C07C231 ,  C07C233 ,  C07C237

CPC分类号： C07C231/08

摘要： The invention provides a process for the preparation of an N-alkyl-acylamino-phenyl-carboxylic acid or carboxylic acid derivative by liquid phase acylation and subsequent N-alkylation of a corresponding amino-phenyl-carboxylic acid (or carboxylic acid derivative), the improvement comprising the addition of an alkylating agent to a solution containing the reaction products of said acylation, to effect said N-alkylation.

公开(公告)号：EP0923537B1

公开(公告)日：2001-10-31

申请号：EP97937743.9

申请日：1997-08-29

申请人： NYCOMED IMAGING AS

发明人： GULBRANDSEN, Trygve ,  INGVOLDSTAD, Odd, Einar ,  HOLMAAS, Lars, Terje

IPC分类号： C07C231/08

CPC分类号： C07C231/08

摘要： The invention provides a process for the preparation of an N-alkyl-acylamino-phenyl-carboxylic acid or carboxylic acid derivative by liquid phase acylation and subsequent N-alkylation of a corresponding amino-phenyl-carboxylic acid (or carboxylic acid derivative), the improvement comprising the addition of an alkylating agent to a solution containing the reaction products of said acylation, to effect said N-alkylation.

公开(公告)号：EP0983227A1

公开(公告)日：2000-03-08

申请号：EP98922946.3

申请日：1998-05-22

申请人： NYCOMED IMAGING AS

发明人： THIELKING, William ,  INGVOLDSTAD, Einar, Odd ,  GULBRANDSEN, Trygve

IPC分类号： C07C231/12 ,  C07C231/22 ,  C07C237/46

CPC分类号： C07C231/12 ,  C07C237/46

摘要： The invention provides a process by which ultra low salt content triiodinated aromatic compounds may be isolated from a highly acidic hot triiodination raction medium in a straightforward fashion. The process involves increasing the pH to above 5 with sodium hydroxide, addition of sodium bisulphite and/or sodium dithionite, addition of seed crystals, cooling slowly, and washing the collected precipitate with water.