发明公开
- 专利标题: NOVEL BENZOFURAN-4-CARBOXAMIDES
- 专利标题(中): 苯并呋喃-4-甲酰胺
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申请号: EP97942858.0申请日: 1997-08-13
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公开(公告)号: EP0923568A1公开(公告)日: 1999-06-23
- 发明人: ULRICH, Wolf-Rüdiger , FLOCKERZI, Dieter , GUTTERER, Beate , THIBAUT, Ulrich , HATZELMANN, Armin , SCHUDT, Christian , BEUME, Rolf , HÄFNER, Dietrich , KLEY, Hans-Peter , AMSCHLER, Hermann
- 申请人: Byk Gulden Lomberg Chemische Fabrik GmbH
- 申请人地址: Byk-Gulden-Str. 2 78467 Konstanz DE
- 专利权人: Byk Gulden Lomberg Chemische Fabrik GmbH
- 当前专利权人: Byk Gulden Lomberg Chemische Fabrik GmbH
- 当前专利权人地址: Byk-Gulden-Str. 2 78467 Konstanz DE
- 优先权: DE19961033052 19960819
- 国际公布: WO1998007715 19980226
- 主分类号: A61K31
- IPC分类号: A61K31 ; A61P11 ; A61P29 ; A61P43 ; C07D307 ; C07D405
摘要:
Compounds of formula (I) in which R1 is 1-2C-alkoxy or 1-2C-alkoxy which is completely or mainly substituted by fluorine, R2 is 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl, Ar is phenyl, pyridyl, phenyl which is substituted by R3, R4 and R5 or pyridyl which is substituted by R6, R7, R8 and R9, where R3 is hydroxyl, halogen, cyano, carboxyl, trifluoromethyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, 1-4C-alkylcarbonyl, 1-4C-alkylcarbonyloxy, amino, mono- or di-1-4C-alkylamino or 1-4C-alkylcarbonylamino, R4 is hydrogen, hydroxyl, halogen, amino, trifluoromethyl, 1-4C-alkyl or 1-4C-alkoxy, R5 is hydrogen, halogen, 1-4C-alkyl or 1-4C-alkoxy, R6 is hydroxyl, halogen, cyano, carboxyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl or amino, R7 is hydrogen, halogen, amino or 1-4C-alkyl, R8 is hydrogen or halogen and R9 is hydrogen or halogen, the salts of this compound, and the N-oxides of the pyridines and their salts are active bronchial therapeutics.
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