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1.发明公开3-CYCLOPROPYLMETHOXY-4-DIFLUOROMETHOXY-N-(3,5-DICHLOROPYRID-4-YL)BENZAMIDE IN THE TREATMENT OF MULTIPLE SCLEROSIS 有权3-环丙基甲氧基-4-二氟甲氧基-N-（3,5-二氯吡啶-4-基） - 苯甲酰胺用于治疗多发性硬化
公开(公告)号：EP1161239A2
公开(公告)日：2001-12-12
申请号：EP00910736.8
申请日：2000-03-01
IPC分类号： A61K31/44 , A61K31/4412 , A61P25/00
CPC分类号： A61K31/4412 , A61K31/44 , Y10S514/903
摘要： The invention relates to the novel use of 3-cyclopropylmethoxy-4-difluoromethoxy-N-(3,5-dichloropyrid-4-yl)benzamide, a pharmacologically tolerable salt thereof or its N-oxide in the treatment of multiple sclerosis.
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公开(公告)号：EP0772610B1
公开(公告)日：2000-10-04
申请号：EP95926953.1
申请日：1995-07-19
发明人： AMSCHLER, Hermann , FLOCKERZI, Dieter , GUTTERER, Beate , HATZELMANN, Armin , SCHUDT, Christian , BEUME, Rolf , HÄFNER, Dietrich , KLEY, Hans-Peter , ULRICH, Wolf-Rüdiger , THIBAUT, Ulrich
IPC分类号： C07D401/12 , C07D307/94 , C07D307/79 , A61K31/34 , A61K31/44
CPC分类号： C07D307/79 , C07D307/94 , C07D405/12 , C07D493/10
摘要： The invention concerns compounds of formula (I), in which R1, R2, R3 and R4 have the meanings given in the description. These compounds are novel, effective PDE-inhibitors.
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公开(公告)号：EP0988302A1
公开(公告)日：2000-03-29
申请号：EP98930737.6
申请日：1998-05-27
发明人： GUTTERER, Beate , ULRICH, Wolf-Rüdiger , AMSCHLER, Hermann , BEUME, Rolf , HÄFNER, Dietrich , BÄR, Thomas , MARTIN, Thomas , KILIAN, Ulrich , ELTZE, Manfrid , BRAND, Ursula , BOSS, Hildegard , KLEY, Hans-Peter , SCHUDT, Christian , GOEBEL, Karl-Josef , FLOCKERZI, Dieter , HATZELMANN, Armin
IPC分类号： C07D471/04 , A61K31/47
CPC分类号： C07D471/04
摘要： The invention concerns the compounds 8,9-Diethoxy-2-methyl-6- [4(p-toluenesulfonamido)phenyl] -1,2,3,4,4a,10b-hexahydrobenzo[c] [1,6]naphthyridine and 9-Ethoxy-8-methoxy-2- methyl-6-[4-(p-toluenesulfonamido) phenyl]-1,2,3,4,4a,10b-hexahydrobenzo [c][1,6]naphthyridine and their therapeutic application.
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公开(公告)号：EP0968211A1
公开(公告)日：2000-01-05
申请号：EP98913621.3
申请日：1998-03-03
发明人： GUTTERER, Beate , AMSCHLER, Hermann , ULRICH, Wolf-Rüdiger , MARTIN, Thomas , BÄR, Thomas , HUMMEL, Rolf-Peter , HATZELMANN, Armin , BOSS, Hildegard , BEUME, Rolf , KLEY, Hans-Peter , HÄFNER, Dietrich , GOEBEL, Karl-Josef , FLOCKERZI, Dieter
IPC分类号： C07D471/04 , A61K31/435
CPC分类号： C07D471/04
摘要： Compounds of formula (I) in which R4 is a phenyl radical substituted by R5, where R5 is a tetrazole-5-yl radical optionally substituted by a radical R6, are novel efficacious PDE3/4 inhibitors.
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公开(公告)号：EP0923568A1
公开(公告)日：1999-06-23
申请号：EP97942858.0
申请日：1997-08-13
发明人： ULRICH, Wolf-Rüdiger , FLOCKERZI, Dieter , GUTTERER, Beate , THIBAUT, Ulrich , HATZELMANN, Armin , SCHUDT, Christian , BEUME, Rolf , HÄFNER, Dietrich , KLEY, Hans-Peter , AMSCHLER, Hermann
CPC分类号： C07D307/79 , C07D405/12
摘要： Compounds of formula (I) in which R1 is 1-2C-alkoxy or 1-2C-alkoxy which is completely or mainly substituted by fluorine, R2 is 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl, Ar is phenyl, pyridyl, phenyl which is substituted by R3, R4 and R5 or pyridyl which is substituted by R6, R7, R8 and R9, where R3 is hydroxyl, halogen, cyano, carboxyl, trifluoromethyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, 1-4C-alkylcarbonyl, 1-4C-alkylcarbonyloxy, amino, mono- or di-1-4C-alkylamino or 1-4C-alkylcarbonylamino, R4 is hydrogen, hydroxyl, halogen, amino, trifluoromethyl, 1-4C-alkyl or 1-4C-alkoxy, R5 is hydrogen, halogen, 1-4C-alkyl or 1-4C-alkoxy, R6 is hydroxyl, halogen, cyano, carboxyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl or amino, R7 is hydrogen, halogen, amino or 1-4C-alkyl, R8 is hydrogen or halogen and R9 is hydrogen or halogen, the salts of this compound, and the N-oxides of the pyridines and their salts are active bronchial therapeutics.
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公开(公告)号：EP0553174B1
公开(公告)日：1998-07-08
申请号：EP91918141.2
申请日：1991-10-12
发明人： AMSCHLER, Hermann , FIGALA, Volker , FLOCKERZI, Dieter , ULRICH, Wolf-Rüdiger , BEUME, Rolf , HÄFNER, Dietrich , HANAUER, Guido , ELTZE, Manfrid , SCHUDT, Christian , KILIAN, Ulrich
IPC分类号： C07D237/14 , A61K31/50
CPC分类号： C07D237/14
摘要： Disclosed are new compounds of general formula (I), in which one of the substituents R1 and R2 is a methoxy, difluoromethoxy or ethoxy group and the other is a C4-C7 cycloalkoxy or C3-C7 cycloalkylmethoxy group, as well as the salts formed by these compounds with bases. The compounds are suitable for use as active ingredients in bronchospasmolytics.
摘要翻译： 公开了通式（I）的新化合物，其中取代基R1和R2之一是甲氧基，二氟甲氧基或乙氧基，另一个是C4-C7环烷氧基或C3-C7环烷基甲氧基，以及形成的盐 通过这些化合物与碱。 这些化合物适合用作支气管痉挛剂中的活性成分。
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公开(公告)号：EP0593567B1
公开(公告)日：1996-08-28
申请号：EP92914201.6
申请日：1992-07-06
IPC分类号： A61K31/50
CPC分类号： A61K31/50
摘要： The invention concerns the use, for the preparation of drugs for use in the treatment of dermatosis, of compounds of the formula (I), in which one of the substituents R1 and R2 is hydrogen, C1-5-alkoxy or difluoromethoxy and the other is C1-5-alkoxy, C4-7-cycloalkoxy, C3-7-cycloalkylmethoxy, C3-5-alkenyloxy or C1-4-polyfluoroalkoxy and X is hydroxy or cyanamino, as well as their pharmacologically tolerated salts with bases.
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公开(公告)号：EP0612247A1
公开(公告)日：1994-08-31
申请号：EP92923587.0
申请日：1992-11-11
IPC分类号： A61K31
CPC分类号： A61K31/47
摘要： L'invention concerne l'utilisation de composés répondant à la formule (I), dans laquelle les substituants ont les propriétés énoncées dans la description, ainsi que de leurs sels compatibles sur le plan pharmacologique, pour fabriquer des médicaments destinés au traitement de dermatoses.
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公开(公告)号：EP0343193A1
公开(公告)日：1989-11-29
申请号：EP88903212.0
申请日：1988-03-24
发明人： ULRICH, Wolf-Rüdiger , AMSCHLER, Hermann , FLOCKERZI, Dieter , KLEMM, Kurt , KOHL, Bernhard , EISTETTER, Klaus , ELTZE, Manfrid , KOLASSA, Norbert , SANDERS, Karl , SCHUDT, Christian
CPC分类号： C07D405/12 , C07D211/90 , C07D401/12 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04
摘要： Des dihydropyridines énantiomériquement pures de formule (I), dans laquelle les substituants et les symboles ont les notations indiquées dans la description, sont de nouveaux composés présentant des propriétés pharmacologiques étonnantes. Un nouveau procédé pour fabriquer ces composés est décrit.
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10.发明授权FLUORALKOXY SUBSTITUIERTE BENZAMIDE UND IHRE VERWENDUNG ALS ZYKLISCH-NUKLEOTID PHOSPHODIESTERASE-INHIBITOREN 失效氟烷氧基取代的苯甲酰胺及其作为环核苷酸磷酸二酯酶抑制剂的用途
公开(公告)号：EP0706513B1
公开(公告)日：2002-05-15
申请号：EP94924713.4
申请日：1994-07-02
发明人： AMSCHLER, Hermann , FLOCKERZI, Dieter , GUTTERER, Beate , HATZELMANN, Armin , SCHUDT, Christian , BEUME, Rolf , KILIAN, Ulrich , WOLF, Horst, P., O.
IPC分类号： C07D213/75 , A61K31/44 , C07C235/56 , A61K31/165
CPC分类号： C07D213/75 , C07C235/56
摘要： Compounds of formula (I), in which one of the substituents R1 or R2 stands for hydrogen, 1-6C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, benzyloxy or totally or partially fluorine-substituted 1-4C-alkoxy, and the other stands for totally or partially fluorine-substituted 1-4C-alkoxy, and R3 stands for phenyl, pyridyl, R31, R32 and R33- substituted phenyl or R34, R35, R36 and R37- substituted pyridyl, in which R31 stands for hydroxy, halogen, cyano, carboxyl, trifluoromethyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, 1-4C-alkylcarbonyl, 1-4C-alkylcarbonyloxy, amino, mono- or di-1-4C-alkylamino or 1-4C-alkylcarbonylamino; R32 stands for hydrogen, hydroxy, halogen, amino, trifluoromethyl, 1-4C-alkyl or 1-4C-alkoxy; R33 stands for hydrogen, halogen, 1-4C-alkyl or 1-4C-alkoxy; R34 stands for hydroxy, halogen, cyano, carboxyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl or amino; R35 stands for hydrogen, halogen, amino or 1-4C-alkyl; R36 stands for hydrogen or halogen; and R37 stands for hydrogen or halogen. These compounds constitute new effective bronchotherapeutic drugs.
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