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公开(公告)号：EP1147088A1
公开(公告)日：2001-10-24
申请号：EP00901530.6
申请日：2000-01-12
发明人： FLOCKERZI, Dieter , AMSCHLER, Hermann DI , GRUNDLER, Gerhard , HATZELMANN, Armin , BUNDSCHUH, Daniela , BEUME, Rolf , BOSS, Hildegard , GOEBEL, Karl-Josef , KLEY, Hans-Peter , GUTTERER, Beate
IPC分类号： C07D221/12 , A61K31/435 , A61P11/08 , C07D401/04 , C07D405/04
CPC分类号： C07D401/04 , C07D221/12 , C07D401/12 , C07D405/04 , C07D409/04 , C07D491/04
摘要： Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and Ar have the meanings indicated in the description, are novel active bronchial therapeutics.
摘要翻译： 其中R 1，R 2，R 3，R 31，R 4，R 5，R 51和Ar具有说明书中指出的含义的式（I）化合物是新的活性支气管疗法。
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公开(公告)号：EP0998460A1
公开(公告)日：2000-05-10
申请号：EP98941361.2
申请日：1998-07-18
发明人： AMSCHLER, Hermann , FLOCKERZI, Dieter , ULRICH, Wolf-Rüdiger , BÄR, Thomas , MARTIN, Thomas , SCHUDT, Christian , HATZELMANN, Armin , BEUME, Rolf , HÄFNER, Dietrich , BOSS, Hildegard , KLEY, Hans-Peter , GUTTERER, Beate
IPC分类号： C07D221/00 , C07D401/10 , A61K31/44 , C07D491/04
CPC分类号： C07D401/10
摘要： Compounds of formula (I) in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel efficacious bronchial therapeutics.
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公开(公告)号：EP0941221A1
公开(公告)日：1999-09-15
申请号：EP97950157.0
申请日：1997-11-11
发明人： AMSCHLER, Hermann , BÄR, Thomas , FLOCKERZI, Dieter , GUTTERER, Beate , THIBAUT, Ulrich , HATZELMANN, Armin , BOSS, Hildegard , BEUME, Rolf , KLEY, Hans-Peter , HÄFNER, Dietrich , MARTIN, Thomas , ULRICH, Wolf-Rüdiger
CPC分类号： C07D405/04 , C07D307/94 , C07D407/04 , C07D409/04 , C07D493/10 , C07F9/65517
摘要： Compounds of formula (I) in which R1 is 1-6C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, benzyloxy or 1-4C-alkoxy which is completely or predominantly substituted by fluorine, R2 is 1-4C-alkyl and R3 is hydrogen or 1-4C-alkyl, or in which R2 and R3, together and including the two carbon atoms to which they are bonded, are a spiro-linked 5-, 6- or 7-membered hydrocarbon ring, if desired interrupted by an oxygen atom or an imino (-NH-) group, R4 is hydrogen, hydroxyl, nitro, cyano, carboxyl, 1-4C-alkoxy or 1-4C-alkoxycarbonyl, A is B, -CH(R5)- or > C = N-R6, where B is oxygen (-O-), imino (-NH-), sulfinyl (-S(O)-), sulfonyl, (-S(O)2-) or carbonylimino (-C(O)NH-) and R5 is carboxyl, 1-4C-alkoxycarbonyl, aminocarbonyl, mono- or di-1-4C-alkylaminocarbonyl, hydroxylaminocarbonyl (-C(O)NHOH), 1-4C-alkoxyaminocarbonyl or a radical of formula (a) where R51 is hydrogen, 1-4C-alkyl or aryl and R52 is hydrogen, 1-4C-alkyl or aryl, where aryl is a phenyl, pyridyl, benzyl or phenethyl radical which can be unsubstituted or mono- or disubstituted by hydroxyl, 1-4C-alkoxy, halogen, amino, cyano or nitro, R6 is hydroxy or 1-4C-alkylcarbonyloxy, and the salts of these compounds are efficacious PDE inhibitors.
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公开(公告)号：EP0882021A1
公开(公告)日：1998-12-09
申请号：EP97904354.0
申请日：1997-01-30
发明人： AMSCHLER, Hermann , FLOCKERZI, Dieter , ULRICH, Wolf-Rüdiger , BÄR, Thomas , MARTIN, Thomas , SCHUDT, Christian , HATZELMANN, Armin , BEUME, Rolf , HÄFNER, Dietrich , BOSS, Hildegard , KLEY, Hans-Peter , GOEBEL, Karl-Josef , GUTTERER, Beate
CPC分类号： C07D221/12
摘要： Compounds of formula (I), where R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings given in the description, are new active bronchial therapeutic agents.
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公开(公告)号：EP0701565A1
公开(公告)日：1996-03-20
申请号：EP94913100.0
申请日：1994-03-31
发明人： GUTTERER, Beate , AMSCHLER, Hermann , FLOCKERZI, Dieter , RIEDEL, Richard , POSTIUS, Stefan , STOECK, Michael , BEUME, Rolf , ZECH, Karl
CPC分类号： C07J71/0005 , C07J71/0031
摘要： Epimers of the compound having the formula (I) are disclosed, both in their pure form and mixed in any desired mix ratio.
摘要翻译： 公开了具有式（I）的化合物的差向异构体，两者都以其纯的形式并以任何所需的混合比混合。
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公开(公告)号：EP1377574A1
公开(公告)日：2004-01-07
申请号：EP02722110.0
申请日：2002-02-21
发明人： FLOCKERZI, Dieter , GUTTERER, Beate , GRUNDLER, Gerhard , HATZELMANN, Armin , BEUME, Rolf , BUNDSCHUH, Daniela , KLEY, Hans-Peter , NAVE, Rüdiger , ZECH, Karl , REUTTER, Felix
IPC分类号： C07D471/04 , A61K31/47 , A61P11/16
CPC分类号： C07D471/04 , A61K31/47 , Y02A50/409 , Y02A50/411
摘要： Compounds of the formula (I), in which R1, R2, R3, R4 and R5 have the meanings indicated in the description, are novel effective PDE3/4 Inhibitors.
摘要翻译： 其中R 1，R 2，R 3，R 4和R 5具有说明书中所示含义的式（I）化合物是新型有效的PDE3 / 4抑制剂。
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公开(公告)号：EP1303506A1
公开(公告)日：2003-04-23
申请号：EP01962844.5
申请日：2001-07-07
发明人： BUNDSCHUH, Daniela , FLOCKERZI, Dieter , GRUNDLER, Gerhard , HATZELMANN, Armin , KLEY, Hans-Peter , WEINBRENNER, Steffen , GUTTERER, Beate
IPC分类号： C07D401/04 , A61K31/473 , A61P11/06 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04
CPC分类号： C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04
摘要： Compounds of the formula I, in which Het is an unsubstituted or R6-and/or R7-sustituted pyrrolyl, furanyl, thiophenyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrimidinyl, pyrazinyl or pyridazinyl radical, or an unsubstituted or R6-and/or R7-substituted fused bi-or tricyclic ring system comprising at least one aromatic ring and up to 4 heteroatoms-selected from the group consisting of O(oxygen), S(sulphur) or N(nitrogen)-which is bonded to the phenanthridinyl radical via one of the rings comprising one or more heteroatoms, areactive PDE4 inhibitors.
摘要翻译： 其中Het为未取代或R6-和/或R7-取代的吡咯基，呋喃基，噻吩基，吡唑基，咪唑基，恶唑基，异恶唑基，噻唑基，异噻唑基，噻二唑基，嘧啶基，吡嗪基或哒嗪基的式I化合物， （氧），S（硫）或N（氮） - 的至少一个芳族环和至多4个杂原子的未取代或R 6 - 和/或R 7 - 取代的稠合双或三环环系统 - 其通过包含一个或多个杂原子的区域性PDE4抑制剂中的一个环与菲啶基结合。
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公开(公告)号：EP1147089A1
公开(公告)日：2001-10-24
申请号：EP00901534.8
申请日：2000-01-12
发明人： FLOCKERZI, Dieter , AMSCHLER, Hermann DI , GRUNDLER, Gerhard , HATZELMANN, Armin , BUNDSCHUH, Daniela , BEUME, Rolf , BOSS, Hildegard , KLEY, Hans-Peter , GUTTERER, Beate
IPC分类号： C07D221/12 , A61K31/435 , C07D401/10 , A61P11/08
CPC分类号： C07D401/12 , C07D221/12 , C07D401/10
摘要： Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51, R6, R13 and R20 has the meanings indicated in the description, are novel active bronchial therapeutics.
摘要翻译： 其中R 1，R 2，R 3，R 31，R 4，R 5，R 51，R 6，R 13和R 20具有说明书中指出的含义的式（I）化合物为新的活性支气管疗法。
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公开(公告)号：EP0772610B1
公开(公告)日：2000-10-04
申请号：EP95926953.1
申请日：1995-07-19
发明人： AMSCHLER, Hermann , FLOCKERZI, Dieter , GUTTERER, Beate , HATZELMANN, Armin , SCHUDT, Christian , BEUME, Rolf , HÄFNER, Dietrich , KLEY, Hans-Peter , ULRICH, Wolf-Rüdiger , THIBAUT, Ulrich
IPC分类号： C07D401/12 , C07D307/94 , C07D307/79 , A61K31/34 , A61K31/44
CPC分类号： C07D307/79 , C07D307/94 , C07D405/12 , C07D493/10
摘要： The invention concerns compounds of formula (I), in which R1, R2, R3 and R4 have the meanings given in the description. These compounds are novel, effective PDE-inhibitors.
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公开(公告)号：EP0988302A1
公开(公告)日：2000-03-29
申请号：EP98930737.6
申请日：1998-05-27
发明人： GUTTERER, Beate , ULRICH, Wolf-Rüdiger , AMSCHLER, Hermann , BEUME, Rolf , HÄFNER, Dietrich , BÄR, Thomas , MARTIN, Thomas , KILIAN, Ulrich , ELTZE, Manfrid , BRAND, Ursula , BOSS, Hildegard , KLEY, Hans-Peter , SCHUDT, Christian , GOEBEL, Karl-Josef , FLOCKERZI, Dieter , HATZELMANN, Armin
IPC分类号： C07D471/04 , A61K31/47
CPC分类号： C07D471/04
摘要： The invention concerns the compounds 8,9-Diethoxy-2-methyl-6- [4(p-toluenesulfonamido)phenyl] -1,2,3,4,4a,10b-hexahydrobenzo[c] [1,6]naphthyridine and 9-Ethoxy-8-methoxy-2- methyl-6-[4-(p-toluenesulfonamido) phenyl]-1,2,3,4,4a,10b-hexahydrobenzo [c][1,6]naphthyridine and their therapeutic application.
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