发明授权
- 专利标题： 4-SUBSTITUTED BETA-CARBOLINES AS IMMUNOMODULATORS
- 专利标题（中）： 4-取代的β-咔啉作为免疫调节剂
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申请号： EP97938122.5申请日： 1997-08-08
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公开(公告)号： EP0923581B1公开(公告)日： 2003-05-21
- 发明人: HARGRAVE, Karl, D. , MIAO, Clara, K. , PARKS, Thomas, P. , POTOCKI, Ian, F. , SNOW, Roger, J.
- 申请人： BOEHRINGER INGELHEIM PHARMACEUTICALS INC.
- 申请人地址： 900 Ridgebury Road, P.O. Box 368 Ridgefield, Connecticut 06877-0368 US
- 专利权人： BOEHRINGER INGELHEIM PHARMACEUTICALS INC.
- 当前专利权人： BOEHRINGER INGELHEIM PHARMACEUTICALS INC.
- 当前专利权人地址： 900 Ridgebury Road, P.O. Box 368 Ridgefield, Connecticut 06877-0368 US
- 代理机构： Laudien, Dieter, Dr.
- 优先权： US23650P 19960809
- 国际公布： WO98006719 19980219
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/44
摘要：
This invention relates to 4-substituted β-carbolines and β-carboline analogs that inhibit Ca+2 influx and interleukin-2 (IL-2) production. The 4-substituted β-carbolines and β-carboline analogs of this invention are represented by formula (I) wherein Q, n, R, R', R'' and R¿1?-R4 are as defined herein. This invention also relates to methods for producing β-carbolines. Because of their selective immunomodulating properties, the compounds and pharmaceutical compositions of this invention are particularly well suited for preventing and treating immune disorders, including autoimmune disease, inflammatory disease, organ transplant rejection and other disorders associated with IL-2 mediated immune response.
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