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公开(公告)号：EP0871619A1
公开(公告)日：1998-10-21
申请号：EP96945567.0
申请日：1996-12-04
发明人： CRUTE, James, J. , FAUCHE, Anne-Marie , GRYGON, Christopher, A. , HARGRAVE, Karl, D. , SIMONEAU, Bruno , THAVONEKHAM, Bounkham
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/28 , C07D277/40 , C07D277/42 , C07D277/46 , C07D277/48 , C07D417/12 , C07D417/14
摘要： This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also relates to thiazolylphenyl derivatives of formula (G) that inhibit the herpes helicase-primase and to pharmaceutical compositions comprising the thiazolylphenyl derivatives, to methods of using and methods of producing the thiazolylphenyl derivatives. In formula (G), R and Z are as defined in the application where Z is the characterising feature.
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2.发明授权2-HETEROARYL-5,11-DIHYDRO-6H-DIPYRIDO [3,2-b:2',3'-e][1,4]DIAZEPINES AND THEIR USE IN THE PREVENTION OR TREATMENT OF HIV INFECTION 失效2 - 杂芳基-5,11-二氢-6H-吡啶并[3,2-B：2”，3'-E] [1,4]二氮杂及其用于HIV感染的预防和治疗
公开(公告)号：EP0745083B1
公开(公告)日：1998-05-20
申请号：EP95910286.4
申请日：1995-02-17
发明人： HARGRAVE, Karl, D. , KELLY, Terence, A. , KAPADIA, Suresh, R. , PROUDFOOT, John, R. , MCNEIL, Daniel, W. , PATEL, Usha, R. , CARDOZO, Mario, G.
IPC分类号： C07D471/14 , A61K31/55
CPC分类号： C07D471/14 , C09B57/00
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3.发明公开
公开(公告)号：EP0551459A1
公开(公告)日：1993-07-21
申请号：EP92912917.0
申请日：1992-05-29
CPC分类号： C07D213/73
摘要： Procédé permettant de préparer une 3-amino-2-chloro-4-alkylpyridine de formule (I), dans laquelle R représente alkyle constitué de un à trois atomes de carbone, qui sert d'intermédiaire dans la préparation de certains composés de 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4] diazépine utiles dans la prévention et le traitement de l'infection provoquée par le VIH.
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公开(公告)号：EP0543000A1
公开(公告)日：1993-05-26
申请号：EP92914035.0
申请日：1992-05-29
CPC分类号： C07D213/73
摘要： Procédé permettant de préparer une 3-amino-2-chloro-4-alkylpyridine de formule (I): dans laquelle R représente alkyle comprenant de un à trois atomes de carbone; qui sert d'intermédiaire dans la préparation de certains composés de 5-11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4] diazépine utiles dans la prévention et le traitement de l'infection provoquée par le VIH.
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公开(公告)号：EP0543000B1
公开(公告)日：1996-12-11
申请号：EP92914035.8
申请日：1992-05-29
IPC分类号： C07D213/73
CPC分类号： C07D213/73
摘要： A process for the preparation of a 3-amino-2-chloro-4-alkylpyridine of formula (I), wherein R is alkyl of from one to three carbon atoms, an intermediate in the preparation of certain 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine compounds useful in the prevention and treatment of HIV infection.
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6.发明公开2-HETEROARYL-5,11-DIHYDRO-6H-DIPYRIDO [3,2-b:2',3'-e][1,4]DIAZEPINES AND THEIR USE IN THE PREVENTION OR TREATMENT OF HIV INFECTION 失效2 - 杂芳基-5,11-二氢-6H-吡啶并[3,2-B：2”，3'-E] [1,4]二氮杂及其用于HIV感染的预防和治疗
公开(公告)号：EP0745083A1
公开(公告)日：1996-12-04
申请号：EP95910286.0
申请日：1995-02-17
发明人： HARGRAVE, Karl, D. , KELLY, Terence, A. , KAPADIA, Suresh, R. , PROUDFOOT, John, R. , MCNEIL, Daniel, W. , PATEL, Usha, R. , CARDOZO, Mario, G.
CPC分类号： C07D471/14 , C09B57/00
摘要： Disclosed are novel 2-heteroaryl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepines of formula (1), wherein Z is an oxygen or sulfur atom, =NCN or a group of the formula =NOR10 wherein R10 is alkyl of 1 to 3 carbon atoms; Ar is a group of formulae (I, II, III, IV or V). These compounds are useful in the prevention or treatment of HIV infections.
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公开(公告)号：EP0923581B1
公开(公告)日：2003-05-21
申请号：EP97938122.5
申请日：1997-08-08
IPC分类号： C07D471/04 , A61K31/44
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444
摘要： This invention relates to 4-substituted β-carbolines and β-carboline analogs that inhibit Ca+2 influx and interleukin-2 (IL-2) production. The 4-substituted β-carbolines and β-carboline analogs of this invention are represented by formula (I) wherein Q, n, R, R', R'' and R¿1?-R4 are as defined herein. This invention also relates to methods for producing β-carbolines. Because of their selective immunomodulating properties, the compounds and pharmaceutical compositions of this invention are particularly well suited for preventing and treating immune disorders, including autoimmune disease, inflammatory disease, organ transplant rejection and other disorders associated with IL-2 mediated immune response.
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公开(公告)号：EP0871619B1
公开(公告)日：2002-11-06
申请号：EP96945567.4
申请日：1996-12-04
发明人： CRUTE, James, J. , FAUCHE, Anne-Marie , GRYGON, Christopher, A. , HARGRAVE, Karl, D. , SIMONEAU, Bruno , THAVONEKHAM, Bounkham
IPC分类号： C07D277/40 , A61K31/425 , C07D417/12 , C07D417/14 , C07D277/28 , C07D277/30 , C07D277/24
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/28 , C07D277/40 , C07D277/42 , C07D277/46 , C07D277/48 , C07D417/12 , C07D417/14
摘要： This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also relates to thiazolylphenyl derivatives of formula (G) that inhibit the herpes helicase-primase and to pharmaceutical compositions comprising the thiazolylphenyl derivatives, to methods of using and methods of producing the thiazolylphenyl derivatives. In formula (G), R and Z are as defined in the application where Z is the characterising feature.
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公开(公告)号：EP0923581A1
公开(公告)日：1999-06-23
申请号：EP97938122.0
申请日：1997-08-08
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444
摘要： This invention relates to 4-substituted β-carbolines and β-carboline analogs that inhibit Ca+2 influx and interleukin-2 (IL-2) production. The 4-substituted β-carbolines and β-carboline analogs of this invention are represented by formula (I) wherein Q, n, R, R', R'' and R¿1?-R4 are as defined herein. This invention also relates to methods for producing β-carbolines. Because of their selective immunomodulating properties, the compounds and pharmaceutical compositions of this invention are particularly well suited for preventing and treating immune disorders, including autoimmune disease, inflammatory disease, organ transplant rejection and other disorders associated with IL-2 mediated immune response.
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10.发明授权
公开(公告)号：EP0551459B1
公开(公告)日：1996-11-20
申请号：EP92912917.9
申请日：1992-05-29
IPC分类号： C07D213/73
CPC分类号： C07D213/73
摘要： A process for the preparation of a 3-amino-2-chloro-4-alkylpyridine of formula (I), wherein R is alkyl of from one to three carbon atoms, an intermediate in the preparation of certain 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine compounds useful in the prevention and treatment of HIV infection.
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