发明公开
- 专利标题： MUSCARINIC ANTAGONISTS
- 专利标题（中）： 毒蕈碱受体拮抗剂
-
申请号： EP97936296.0申请日： 1997-08-06
-
公开(公告)号： EP0938483A2公开(公告)日： 1999-09-01
- 发明人: LOWE, Derek, B. , CHANG, Wei, K. , KOZLOWSKI, Joseph, A. , BERGER, Joel, G. , McQUADE, Robert , BARNETT, Allen , SHERLOCK, Margaret , TOM, Wing , DUGAR, Sundeep , CHEN, Lian-Yong , CLADER, John, W. , CHACKALAMANNIL, Samuel , WANG, Yuguang , McCOMBIE, Stuart, W. , TAGAT, Jayaram, R. , VICE, Susan, F. , VACCARO, Wayne, D. , GREEN, Michael, J. , BROWNE, Margaret, E. , BOYLE, Craig, D. , JOSIEN, Hubert, B. , ASBEROM, Theodros
- 申请人： SCHERING CORPORATION
- 申请人地址： 2000 Galloping Hill Road Kenilworth New Jersey 07033 US
- 专利权人： SCHERING CORPORATION
- 当前专利权人： SCHERING CORPORATION
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth New Jersey 07033 US
- 代理机构： Ritter, Stephen David, et al
- 优先权： US19960700628 19960808
- 国际公布： WO1998005292 19980212
- 主分类号： C07D211
- IPC分类号： C07D211 ; A61K31 ; A61K45 ; A61P25 ; C07D239 ; C07D257 ; C07D295 ; C07D401 ; C07D405 ; C07D409 ; C07D413
摘要：
Di-N-substituted piperazine or 1,4 di-substituted piperidine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) wherein R, R?1, R2, R3, R4, R21, R27, R28¿, X, Y and Z as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations of compounds of the above formula with acetylcholinesterase inhibitors.
信息查询
