发明公开
EP0979286A2 COMBINATORIAL POLYKETIDE LIBRARIES PRODUCED USING A MODULAR PKS GENE CLUSTER AS SCAFFOLD
失效
使用模块化PKS基因簇作为分支构建组合型多肽库
- 专利标题： COMBINATORIAL POLYKETIDE LIBRARIES PRODUCED USING A MODULAR PKS GENE CLUSTER AS SCAFFOLD
- 专利标题（中）： 使用模块化PKS基因簇作为分支构建组合型多肽库
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申请号： EP98918891.7申请日： 1998-04-30
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公开(公告)号： EP0979286A2公开(公告)日： 2000-02-16
- 发明人: KHOSLA, Chaitan , ASHLEY, Gary , FU, Hong , KAO, Camilla, M. , MCDANIEL, Robert
- 申请人： Kosan Biosciences , THE BOARD OF TRUSTEES OFTHE LELAND STANFORD JUNIOR UNIVERSITY
- 申请人地址： 1450 Rollins Road Burlingame, CA 94010 US
- 专利权人： Kosan Biosciences,THE BOARD OF TRUSTEES OFTHE LELAND STANFORD JUNIOR UNIVERSITY
- 当前专利权人： Kosan Biosciences,THE BOARD OF TRUSTEES OFTHE LELAND STANFORD JUNIOR UNIVERSITY
- 当前专利权人地址： 1450 Rollins Road Burlingame, CA 94010 US
- 代理机构： Irvine, Jonquil Claire
- 优先权： US846247 19970430; US76919P 19980305
- 国际公布： WO9849315 19981105
- 主分类号： C12N15/52
- IPC分类号： C12N15/52 ; C12N15/76 ; C12N9/00 ; C12N1/21 ; C12P17/06 ; C07D309/00 ; C07D313/04 ; C07D493/10 ; C07D313/00 ; C07H17/04
摘要：
Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
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