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1.发明公开TRANS-9, 10-DEHYDROEPOTHILONE C AND D, ANALOGS THEREOF AND METHODS OF MAKING THE SAME 审中-公开TRANS 9,10-DEHYDROEPOTHILON C UND D，DEREN DERIVATE UND VERFAHREN ZU IHREN HERSTELLUNG
公开(公告)号：EP2135868A1
公开(公告)日：2009-12-23
申请号：EP09012860.4
申请日：2003-11-07
发明人： Li, Yong , Sundermann, Kurt , Myles, David
IPC分类号： C07D417/06 , C07D413/06 , C07D405/06 , A61K31/427
CPC分类号： C07D405/06 , C07D413/06 , C07D417/06
摘要： The present invention provides a method of making trans -9,10-dehydroepothilones, comprising converting a 9-oxo-epothilone into the trans -9,10-dehydroepothilone.
摘要翻译： 本发明提供了制备反-9,10-脱氢表皮素的方法，其包括将9-氧代 - 埃坡霉素转化成反-9,10-脱氢表雄酮。
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2.发明公开Trans-9, 10-dehydroepothilone C and trans-9, 10-dehydroepothilone D, analogs thereof and methods of making the same 有权反-9,10-脱氢山梨醇和反式-9,10-脱氢表面活性剂D，Analoga davon und Verfahren zu deren Herstellung
公开(公告)号：EP2135867A1
公开(公告)日：2009-12-23
申请号：EP09012671.5
申请日：2003-11-07
发明人： Li, Yong , Sundermann, Kurt , Tang, Li , Myles, David
IPC分类号： C07D417/06 , C07D413/06 , C07D405/06 , A61K31/427 , A61P35/00
CPC分类号： C07D405/06 , C07D413/06 , C07D417/06
摘要： The present invention provides new trans -9,10-dehydroepothilone C and trans- 9,10-dehydroepothilone D based derivative compounds, compositions and methods of inhibiting cellular hyperproliferation and/or stabilizing microtubules in vitro and of treatment of hyperproliferative diseases in vivo . Also disclosed are methods of making the compounds.
摘要翻译： 本发明提供了新的反-9,10-脱氢表皮素C和反-9,10-脱氢表皮龙脑D衍生物化合物，体外抑制细胞过度增殖和/或稳定微管的组合物和方法以及体内过度增殖性疾病的治疗。 还公开了制备该化合物的方法。
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公开(公告)号：EP1794137A4
公开(公告)日：2009-12-02
申请号：EP05799606
申请日：2005-09-26
IPC分类号： C07D267/22 , A61K31/33 , A61K31/365 , A61K31/4178 , A61K31/5377 , A61P35/00 , C07D245/00 , C07D281/18 , C07D291/00 , C07D327/00 , C07D337/16 , C07D343/00 , C07D411/00 , C07D487/00 , C07D497/00 , C07D513/00
CPC分类号： A61K31/33 , A61K31/365 , A61K31/4178 , A61K31/5377 , C07D493/04
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公开(公告)号：EP1485462B1
公开(公告)日：2007-12-12
申请号：EP03719319.0
申请日：2003-02-25
CPC分类号： C12N1/20 , C12N15/52 , C12P17/162 , C12P17/167 , C12P17/181
摘要： The present invention provides a generalized oxygen-limited cultivation method for myxobacterial strains engineered to heterologously express polyketides synthase (PKS) gene clusters under various oxygen tension conditions, modulating the polyketide congener distribution.
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公开(公告)号：EP1224300B9
公开(公告)日：2007-09-26
申请号：EP00972384.2
申请日：2000-10-27
发明人： SANTI, Daniel , PECK, Larry , DAYEM, Linda , KEALEY, James
摘要： Recombinant host cells that comprise recombinant DNA expression vectors that drive expression of a product and a precursor for biosynthesis of that product can be used to produce useful products such as polyketides in host cells that do not naturally produce the product or produce the product or precursor at low levels due to the absence of the precursor or the presence of the precursor in rate limiting amounts.
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公开(公告)号：EP1576140A4
公开(公告)日：2007-08-08
申请号：EP03798802
申请日：2003-09-26
摘要： The invention provides strategies, methods, vectors, reagents, and systems for production of synthetic genes, production of libraries of such genes, and manipulation and characterization of the genes and corresponding encoded polypeptides. In one aspect, the synthetic genes can encode polyketide synthase polypeptides and facilitate production of therapeutically or commercially important polyketide compounds.
摘要翻译： 本发明提供了用于生产合成基因的策略，方法，载体，试剂和系统，这些基因文库的生产以及基因和相应编码多肽的操作和表征。 一方面，合成基因可编码聚酮化合物合酶多肽并促进产生治疗或商业上重要的聚酮化合物。
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公开(公告)号：EP1244800B1
公开(公告)日：2007-03-14
申请号：EP00990461.6
申请日：2000-10-30
发明人： KATZ, Leonard , LIU, Lu , CHUNG, Loleta, M.
IPC分类号： C12N15/76 , C07D498/18 , A61K31/435
CPC分类号： C07D498/18 , C12N9/1029 , C12N15/52 , C12P17/188
摘要： Recombinant host cells that produce rapamycin analogues are constructed by deleting or modifying rapamycin biosynthetic gene cluster genes and are useful in the production of compounds used as antifungals, anticancers, immunosuppressants, and neurotrophins.
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公开(公告)号：EP1754700A2
公开(公告)日：2007-02-21
申请号：EP06120607.4
申请日：2000-01-27
IPC分类号： C07C327/30 , C12P17/08 , C07D239/38
CPC分类号： C07C327/30
摘要： Facile methods for preparing diketide and triketide thioesters are disclosed. The resulting thioesters may be used as intermediates in the synthesis of desired polyketides, and may contain functional groups which ultimately reside in side chains on the resulting polyketide and thus can be used further to manipulate the polyketide so as to form derivatives. The polyketides produced may also be tailored by glycosylation, hydroxylation and the like. New polyketides and their derivatives and tailored forms are thereby produced.
摘要翻译： 公开了制备二酮化合物和三酮化物硫酯的简便方法。 所得硫酯可用作合成所需聚酮化合物的中间体，并且可以含有最终存在于所得聚酮化合物上的侧链中的官能团，因此可以进一步用于操作聚酮化合物以形成衍生物。 产生的聚酮化合物也可以通过糖基化，羟基化等来定制。 由此生产新的聚酮化合物及其衍生物和定制的形式。
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公开(公告)号：EP1740713A2
公开(公告)日：2007-01-10
申请号：EP05767675.1
申请日：2005-04-05
CPC分类号： C12N15/1031 , C12N15/1058 , C12N15/52 , C12N15/64 , C12N15/66
摘要： The invention provides strategies, methods, vectors, reagents, and systems for production of synthetic genes, production of libraries of such genes, and manipulation and characterization of the genes and corresponding encoded polypeptides. In one aspect, the synthetic genes can encode polyketide synthase polypeptides and facilitate production of therapeutically or commercially important polyketide compounds.
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公开(公告)号：EP1471923A4
公开(公告)日：2006-01-11
申请号：EP03713257
申请日：2003-01-17
发明人： ASHLEY GARY , SHAW SIMON JAMES , LI YANDONG
IPC分类号： A61K31/7048 , A61P1/00 , A61P3/10 , A61P31/04 , C07H17/08
CPC分类号： C07H17/08 , Y02P20/582
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