发明授权
EP1003718B1 VERFAHREN ZUR HERSTELLUNG VON N-(5-AMINO-2-CYANO-4-FLUOR-PHENYL)-SULFONAMIDEN 失效
N-(5-氨基-2-氰基-4-氟 - 苯基) - 磺酰胺

VERFAHREN ZUR HERSTELLUNG VON N-(5-AMINO-2-CYANO-4-FLUOR-PHENYL)-SULFONAMIDEN
摘要:
The invention relates to a method for producing N-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamides. In a first step, 2-amino-4,5-difluoro-benzonitrile is reacted with sulphonic acid halogenides in the presence of an acid acceptor and a diluting agent at temperatures between 0 °C and 150 °C. In a second step, the N-(2-cyano-4,5-difluoro-phenyl)-sulphonamide and/or N-(2-cyano-4,5-difluoro-phenyl)-sulphonamides are reacted, either in the pure state or mixed, with ammonia in the presence of a diluting agent at temperatures between 100 °C and 200 °C. The invention also relates to new intermediate products of this method.
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