发明授权
EP1003718B1 VERFAHREN ZUR HERSTELLUNG VON N-(5-AMINO-2-CYANO-4-FLUOR-PHENYL)-SULFONAMIDEN
失效
N-(5-氨基-2-氰基-4-氟 - 苯基) - 磺酰胺
- 专利标题: VERFAHREN ZUR HERSTELLUNG VON N-(5-AMINO-2-CYANO-4-FLUOR-PHENYL)-SULFONAMIDEN
- 专利标题(英): Method for the production of n-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamides
- 专利标题(中): N-(5-氨基-2-氰基-4-氟 - 苯基) - 磺酰胺
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申请号: EP98940212.8申请日: 1998-07-13
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公开(公告)号: EP1003718B1公开(公告)日: 2004-04-28
- 发明人: HUPPERTS, Achim , DREWES, Mark, Wilhelm , ERDMAN, David , LANTZSCH, Reinhard
- 申请人: Bayer CropScience AG
- 申请人地址: Alfred-Nobel-Strasse 50 40789 Monheim DE
- 专利权人: Bayer CropScience AG
- 当前专利权人: Bayer CropScience AG
- 当前专利权人地址: Alfred-Nobel-Strasse 50 40789 Monheim DE
- 优先权: DE19731783 19970724
- 国际公布: WO1999005098 19990204
- 主分类号: C07C303/38
- IPC分类号: C07C303/38 ; C07C303/40 ; C07C211/52 ; C07C311/08 ; C07C311/48
摘要:
The invention relates to a method for producing N-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamides. In a first step, 2-amino-4,5-difluoro-benzonitrile is reacted with sulphonic acid halogenides in the presence of an acid acceptor and a diluting agent at temperatures between 0 °C and 150 °C. In a second step, the N-(2-cyano-4,5-difluoro-phenyl)-sulphonamide and/or N-(2-cyano-4,5-difluoro-phenyl)-sulphonamides are reacted, either in the pure state or mixed, with ammonia in the presence of a diluting agent at temperatures between 100 °C and 200 °C. The invention also relates to new intermediate products of this method.
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