公开(公告)号：EP3923938A1

公开(公告)日：2021-12-22

申请号：EP20754897.5

申请日：2020-02-14

申请人： Algernon Pharmaceuticals Inc.

发明人： WILLIAMS, Mark

IPC分类号： A61K31/4741 ,  A61K31/136 ,  A61K31/4184 ,  A61K31/445 ,  A61K31/454 ,  A61P11/00 ,  C07C211/52 ,  C07D211/22 ,  C07D235/28 ,  C07D413/12 ,  C07D491/052

公开(公告)号：EP3578176A1

公开(公告)日：2019-12-11

申请号：EP19188591.2

申请日：2014-10-08

申请人： Lu, Qing-Bin

发明人： Lu, Qing-Bin

IPC分类号： A61K31/136 ,  A61K31/44 ,  A61K31/495 ,  A61K31/4965 ,  C07D213/73 ,  C07C211/52 ,  C07D241/20 ,  A61P35/00 ,  A61P1/06 ,  A61P17/06 ,  A61P19/02 ,  A61P25/00 ,  A61P37/06

摘要： Disclosed herein are non-platinum-based (NPB) anti-cancer compounds useful for targeted chemotherapy, e.g., to generate anti-cancer effects for the treatment of cancer and other disorders while having no or minimal toxicity. The compounds have the general formula III:

Wherein X and Y are independently C-R 3 or N; R 1 is a halogen selected from the group of CI, Br, I or F;one of R 2 and R 3 is H, OH, halogen, alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heterocyclyl, or heteroaryl, and the other of R 2 and R 3 is H or halogen; wherein each of the alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heterocyclyl and heteroaryl moieties is optionally substituted by one or more functional groups selected from the list consisting of hydroxyl, amino, amido, cyano, nitro, carboxyl, ester, ether, ketone, aldehyde, or a combination thereof;or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP3562817A1

公开(公告)日：2019-11-06

申请号：EP17828936.9

申请日：2017-12-28

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Université Paris Diderot Paris 7

发明人： LAINE, Philippe ,  POULARD, Laurélie ,  DUPEYRE, Grégory

IPC分类号： C07D321/00 ,  C07C43/205 ,  C07C211/50 ,  C07C211/52 ,  C07C217/76 ,  C07C217/80 ,  C07C217/84 ,  C07C217/94 ,  C07D471/04 ,  C07D209/88 ,  C07F7/08 ,  C09B11/02 ,  C09B11/06 ,  C09B11/12 ,  C09B11/22 ,  C07D295/135

公开(公告)号：EP2589688B1

公开(公告)日：2017-03-01

申请号：EP11800598.2

申请日：2011-06-10

申请人： Riken

发明人： SAITO, Mikiko ,  NOTAKE, Takashi ,  MINAMIDE, Hiroaki ,  ITO, Hiromasa

IPC分类号： C30B29/54 ,  C07C211/52 ,  C30B7/08 ,  C30B7/00

CPC分类号： C30B7/08 ,  C07B2200/13 ,  C07C211/52 ,  C30B7/00 ,  C30B7/005 ,  C30B29/54 ,  G02F1/3551

公开(公告)号：EP2776387B1

公开(公告)日：2017-02-01

申请号：EP12846967.3

申请日：2012-11-07

申请人： Emory University

发明人： NATCHUS, Michael G. ,  ARRENDALE, Richard F.

IPC分类号： C07C229/60 ,  C07C211/53 ,  C07D213/74 ,  C07C211/52 ,  C07D401/12 ,  C07D403/12 ,  C07D239/42 ,  C07C217/84 ,  C07C229/54 ,  A61K31/505 ,  A61K31/506 ,  A61K31/444 ,  A61K31/138 ,  A61K31/4166 ,  A61K31/167 ,  A61K31/57 ,  A61K31/575 ,  A61K31/58 ,  A61P5/00 ,  A61P5/24 ,  A61K31/137

CPC分类号： A61K31/506 ,  A61K31/137 ,  A61K31/138 ,  A61K31/167 ,  A61K31/4166 ,  A61K31/444 ,  A61K31/505 ,  A61K31/57 ,  A61K31/575 ,  A61K31/58 ,  A61K38/2073 ,  A61K45/06 ,  C07C211/27 ,  C07C211/52 ,  C07C211/53 ,  C07C229/60 ,  C07C233/11 ,  C07C233/58 ,  C07C233/64 ,  C07C233/65 ,  C07C233/75 ,  C07C237/40 ,  C07C255/58 ,  C07C279/04 ,  C07C279/18 ,  C07D213/72 ,  C07D213/74 ,  C07D239/42 ,  C07D401/12 ,  C07D403/12 ,  A61K2300/00

摘要： The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.

摘要翻译： 本公开提供了使用的某些化合物的方法确实可用于治疗内分泌紊乱的某些症状是有用的，特别是那些与潮热相关联。

公开(公告)号：EP3004058A2

公开(公告)日：2016-04-13

申请号：EP14806879.4

申请日：2014-05-19

申请人： Université de Caen

发明人： DALLEMAGNE, Patrick ,  ROCHAIS, Christophe ,  LECOUTEY, Cédric ,  BOULOUARD, Michel ,  FRERET, Thomas

IPC分类号： C07D211/20 ,  A61K31/445 ,  C07D211/26 ,  C07D211/32 ,  A61P25/28 ,  C07C211/52 ,  A61K31/4468

CPC分类号： C07D211/34 ,  C07D211/20 ,  C07D211/26 ,  C07D211/32

摘要： The invention relates to compounds of formula (I) as well as to neurogenic enantiomers thereof, acid salts thereof, hydrates thereof or to solvation products thereof. Among a large number of possible meanings, X is a halogen, Y is an oxygen atom; all the coefficients m, n, r and s have a value of 1, R is a methyl, and R' is a cycloalkyl. The invention also includes methods for preparing the above compounds and pharmaceutical compositions including same.

摘要翻译： 化合物提供gemäß式（I），以及它们的对映异构体及其racemics，它们的酸的盐，水合物或它们的溶剂化他们的产品。 在大量的可能的含义，X为卤素一个darstellt，Y以氧原子; 所有的系数M，N，R和S具有值1，乙基和R“的环的řdarstellt。 因此，本发明包括制备这样设置上述化合物和含有它们的药物组合物的方法。

公开(公告)号：EP2822924A1

公开(公告)日：2015-01-14

申请号：EP13710324.8

申请日：2013-03-07

申请人： BASF SE

发明人： HEINRICH, Markus ,  JASCH, Hannelore ,  HÖFLING, Sarah

IPC分类号： C07C209/68 ,  C07C211/45 ,  C07C211/52 ,  C07C213/08 ,  C07C217/84 ,  C07C253/30 ,  C07C255/58 ,  C07C217/80

CPC分类号： C07C209/68 ,  C07C213/08 ,  C07C253/30 ,  C07C211/52 ,  C07C211/45 ,  C07C217/84 ,  C07C217/80 ,  C07C255/58

摘要： The present invention describes a method for synthesising 2-aminobiphenyls and derivatives thereof. This method can be performed cost-effectively and is based on selective reactions. Functionalised biphenyl compounds are of great interest, particularly as pharmaceuticals and agricultural chemicals, and as precursors for such active ingredients. The method for producing a compound of formula 3 is characterised in that a compound of formula 1 is reacted with a compound of formula 2 in the presence of an oxidising agent.

公开(公告)号：EP1528052B1

公开(公告)日：2013-07-31

申请号：EP04025390.8

申请日：2004-10-26

申请人： FINCHIMICA S.p.A.

发明人： Pastorio, Andrea ,  Mollica, Daniela ,  Ravetta, Giacomo ,  Mancini, Gianluca

IPC分类号： C07C17/12 ,  C07C25/02 ,  C07C17/20 ,  C07C22/08 ,  C07C209/10 ,  C07C211/52

CPC分类号： C07C209/10 ,  C07C17/12 ,  C07C17/206 ,  C07C25/13 ,  C07C211/52

公开(公告)号：EP2216356A1

公开(公告)日：2010-08-11

申请号：EP08853335.1

申请日：2008-11-20

申请人： Sumitomo Chemical Company, Limited ,  Sumation Co., Ltd.

发明人： OHUCHI, Kazuei ,  ANRYU, Makoto

IPC分类号： C08G61/10 ,  C07C205/12 ,  C07C209/10 ,  C07C209/18 ,  C07C211/52 ,  C07C211/56 ,  C09K11/06 ,  H01L51/50

CPC分类号： C07C17/23 ,  C07C17/12 ,  C07C17/2637 ,  C07C17/269 ,  C07C205/11 ,  C07C205/12 ,  C07C211/46 ,  C07C211/54 ,  C07C211/56 ,  C07C211/61 ,  C07C2603/18 ,  C07C2603/24 ,  C08G61/02 ,  C08G61/12 ,  C08G61/124 ,  C08G61/125 ,  C09B57/00 ,  C09B57/008 ,  C09B69/109 ,  C09K11/06 ,  C09K2211/1433 ,  C09K2211/1466 ,  H01L51/0039 ,  H01L51/004 ,  H01L51/0043 ,  H01L51/5012 ,  H05B33/14 ,  C07C25/22

摘要： Disclased is a polymeric compound having a constitutional unit represented by formula (1a), wherein ring A and ring B independently represent an aromatic hydrocarbon ring which may have a substituent; R1 represents a group represented by formula (2); and R2 represents an aryl group or a monovalent aromatic heterocyclic group which may be substituted by an alkyl group or the like. In formula (2), Ar1 to Ar3 independently represent an arylene group or a divalent group to which two or more arylene groups are attached via a single bond; Ar4 to Ar7 independently represent an aryl group or a monovalent aromatic heterocyclic group; R6 represents a hydrogen atom, an alkyl group, an aryl group or a monovalent aromatic heterocyclic group; Ar1 to Ar7 and R6 may be substituted by an alkyl group or the like; and k and kk independently represent an integer of 0 to 3, provided that at least one of k and kk represents an integer of 1 to 3.

摘要翻译： Disclased是具有由式（1a）表示的结构单元的聚合物，其中环A和环B独立地表示可以具有取代基的芳族烃环; R1表示由式（2）表示的基团; R2表示可以被烷基等取代的芳基或1价的芳香族杂环基。 在式（2）中，Ar 1至Ar 3独立地表示亚芳基或通过单键与两个以上亚芳基连接的二价基团; Ar 4至Ar 7独立地表示芳基或一价芳族杂环基; R6表示氢原子，烷基，芳基或一价芳族杂环基; Ar 1〜Ar 7和R 6可以被烷基等取代; 并且k和kk独立地表示0至3的整数，条件是k和kk中的至少一个表示1至3的整数。

公开(公告)号：EP1798216A4

公开(公告)日：2008-12-03

申请号：EP05785694

申请日：2005-09-26

申请人： SANKYO CO

发明人： KAJINO HISAKI ,  MIYAMOTO HIROSHI ,  IKEUCHI YUTAKA ,  OKAZAKI REI

IPC分类号： C07C217/84 ,  C07C209/10 ,  C07C211/52 ,  C07C213/00 ,  C07C271/28 ,  C07D277/20 ,  C07D277/34 ,  C07D417/12

CPC分类号： C07D277/34 ,  C07C217/90 ,  C07C271/28 ,  C07C323/36 ,  C07D417/12

摘要： Disclosed are novel production intermediates (IIa) and (III) of a 6-substituted-1-methyl-1-H-benzimidazole derivative (I) as a publicly-known pharmaceutically active ingredient. Also disclosed is a production method suitable for mass synthesis of N-(5-substituted-2-nitrophenyl)-N-methylamines (II) as production intermediates. Further disclosed is a method for efficiently producing a 6-substituted-1-methyl-1-H-benzimidazole derivative (I) from a production intermediate (II) through a short process. The present invention relates to a method for producing a compound (I) represented by the formula below and a production intermediate of the compound (I). (III) (I) (In the formula, R2 represents a phenyl group which may have a substituent such as a C1-C6 alkyl group or the like, and X represents an oxygen atom, a sulfur atom or a nitrogen atom.)