发明授权
EP1012274B2 DEATH DOMAIN CONTAINING RECEPTOR 4 (DR4: DEATH RECEPTOR 4), MEMBER OF THE TNF-RECEPTOR SUPERFAMILY AND BINDING TO TRAIL (AP0-2L)
失效
“死亡结构域” 的含受体4（DR4），TNF受体超家族，其中TRAIL（APO-2L）结合成员
- 专利标题： DEATH DOMAIN CONTAINING RECEPTOR 4 (DR4: DEATH RECEPTOR 4), MEMBER OF THE TNF-RECEPTOR SUPERFAMILY AND BINDING TO TRAIL (AP0-2L)
- 专利标题（中）： “死亡结构域” 的含受体4（DR4），TNF受体超家族，其中TRAIL（APO-2L）结合成员
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申请号： EP98904690.9申请日： 1998-01-27
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公开(公告)号： EP1012274B2公开(公告)日： 2011-06-15
- 发明人: GENTZ, Reiner, L. , NI, Jian , ROSEN, Craig, A. , DIXIT, Vishva, M. , PAN, James, G.
- 申请人： HUMAN GENOME SCIENCES, INC. , THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- 申请人地址： 14200 Shady Grove Road Rockville, MD 20850 US
- 专利权人： HUMAN GENOME SCIENCES, INC.,THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- 当前专利权人： HUMAN GENOME SCIENCES, INC.,THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- 当前专利权人地址： 14200 Shady Grove Road Rockville, MD 20850 US
- 代理机构： Vossius & Partner
- 优先权： US35722P 19970128; US37829P 19970205
- 国际公布： WO1998032856 19980730
- 主分类号： C12N15/12
- IPC分类号： C12N15/12 ; C07K16/28 ; C07K14/705
摘要：
The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity.
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