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1.发明授权DEATH DOMAIN CONTAINING RECEPTOR 4 (DR4: DEATH RECEPTOR 4), MEMBER OF THE TNF-RECEPTOR SUPERFAMILY AND BINDING TO TRAIL (AP0-2L) 失效“死亡结构域” 的含受体4（DR4），TNF受体超家族，其中TRAIL（APO-2L）结合成员
公开(公告)号：EP1012274B2
公开(公告)日：2011-06-15
申请号：EP98904690.9
申请日：1998-01-27
IPC分类号： C12N15/12 , C07K16/28 , C07K14/705
CPC分类号： C07K14/70578
摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity.
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2.发明公开DEATH DOMAIN CONTAINING RECEPTOR 4 (DR4: DEATH RECEPTOR 4), MEMBER OF THE TNF-RECEPTOR SUPERFAMILY AND BINDING TO TRAIL (AP02-L) 失效“死亡结构域” 的含受体4（DR4），TNF受体超家族，其中TRAIL（APO-2L）结合成员
公开(公告)号：EP1012274A1
公开(公告)日：2000-06-28
申请号：EP98904690.9
申请日：1998-01-27
IPC分类号： C12N15/12 , C07K16/28 , C07K14/705
CPC分类号： C07K14/70578
摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity.
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3.发明授权DEATH DOMAIN CONTAINING RECEPTOR 4 (DR4: DEATH RECEPTOR 4), MEMBER OF THE TNF-RECEPTOR SUPERFAMILY AND BINDING TO TRAIL (AP0-2L) 失效“死亡” - 真人反应器4（DR4），EIN MITGLIED DER TNF-REZEPTOR SUPERFAMILIE，WELCHER AN TRAIL（APO-2L）BINDET
公开(公告)号：EP1012274B1
公开(公告)日：2007-05-23
申请号：EP98904690.9
申请日：1998-01-27
IPC分类号： C12N15/12 , C07K16/28 , C07K14/705
CPC分类号： C07K14/70578
摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity.
摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。 特别地，提供编码人DR4蛋白的分离的核酸分子。 还提供DR4多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及鉴定DR4活性的激动剂和拮抗剂的筛选方法。
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