发明公开
EP1020530A1 PROCESS FOR THE PREPARATION OF HMG-CoA REDUCTASE INHIBITORS
失效
VERFAHRENFÜRDIE HERSTELLUNG VON INHIBITOREN DER HMG-CoA-REDUKTASE。
- 专利标题： PROCESS FOR THE PREPARATION OF HMG-CoA REDUCTASE INHIBITORS
- 专利标题（中）： VERFAHRENFÜRDIE HERSTELLUNG VON INHIBITOREN DER HMG-CoA-REDUKTASE。
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申请号： EP98935282.8申请日： 1998-07-30
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公开(公告)号： EP1020530A1公开(公告)日： 2000-07-19
- 发明人: TAKANO, Yutaka , HASEGAWA, Masaru , MORI, Hideo , ANDO, Katsuhiko , OCHIAI, Keiko , MOTOYAMA, Hiroaki , OZAKI, Akio
- 申请人： KYOWA HAKKO KOGYO CO., LTD.
- 申请人地址： 6-1, Ohtemachi 1-chome Chiyoda-ku, Tokyo 100-8185 JP
- 专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人地址： 6-1, Ohtemachi 1-chome Chiyoda-ku, Tokyo 100-8185 JP
- 代理机构： VOSSIUS & PARTNER
- 优先权： JP21363697 19970807
- 国际公布： WO9907872 19990218
- 主分类号： C12P7/62
- IPC分类号： C12P7/62 ; C12P17/06 ; C12N1/20
摘要：
Disclosed is a process for producing a compound represented by general formula (II-a):
(wherein R 1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R 2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (II-a)] or the lactone form of Compound (II-a) [hereinafter referred to as Compound (II-b)] which comprises subjecting a compound represented by general formula (I-a):
(wherein R 1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R 2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (I-a)] or the lactone form of Compound (I-a) [hereinafter referred to as Compound (I-b)] to the action of an enzyme source derived from a microorganism belonging to the genus Bacillus and capable of converting Compound (I-a) or Compound (I-b) into Compound (II-a) or Compound (II-b) in a reaction mixture to form Compound (II-a) or Compound (II-b) in the reaction mixture, and recovering Compound (II-a) or Compound (II-b) from the reaction mixture.
(wherein R 1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R 2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (II-a)] or the lactone form of Compound (II-a) [hereinafter referred to as Compound (II-b)] which comprises subjecting a compound represented by general formula (I-a):
(wherein R 1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R 2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (I-a)] or the lactone form of Compound (I-a) [hereinafter referred to as Compound (I-b)] to the action of an enzyme source derived from a microorganism belonging to the genus Bacillus and capable of converting Compound (I-a) or Compound (I-b) into Compound (II-a) or Compound (II-b) in a reaction mixture to form Compound (II-a) or Compound (II-b) in the reaction mixture, and recovering Compound (II-a) or Compound (II-b) from the reaction mixture.
公开/授权文献
- EP1020530B1 PROCESS FOR THE PREPARATION OF HMG-CoA REDUCTASE INHIBITORS 公开/授权日：2008-03-12
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