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1.发明公开PROCESS FOR PRODUCING HMG-CoA REDUCTASE INHIBITOR 有权VERFAHREN ZUR HERSTELLUNG EINES HMG-COA REDUKTASE HEMMERS
公开(公告)号：EP1148122A1
公开(公告)日：2001-10-24
申请号：EP00901980.3
申请日：2000-01-28
CPC分类号： C12N9/0004 , C07K14/32 , C12P7/62 , C12P17/06
摘要： The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a):
wherein R 1 represents a hydrogen atom, a substituted or unsubstituted alkyl, or an alkali metal, and R 2 represents a substituted or unsubstituted alkyl or a substituted or unsubstituted aryl,
or a ring-closed lactone form thereof;
a DNA encoding said protein; and a recombinant DNA comprising said DNA.摘要翻译： 本发明涉及一种衍生自属于芽孢杆菌属的微生物的蛋白质，其具有使由式（Ia）表示的化合物羟基化的活性：其中R 1表示氢原子，取代或未取代的 烷基或碱金属，R 2表示取代或未取代的烷基或取代或未取代的芳基或其封闭的内酯形式; 编码所述蛋白质的DNA; 和包含所述DNA的重组DNA。
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公开(公告)号：EP0861902A1
公开(公告)日：1998-09-02
申请号：EP97940364.9
申请日：1997-09-12
发明人： KOIZUMI, Satoshi , KAWANO, Hisaji , KINO, Kuniki , OZAKI, Akio
CPC分类号： C12P19/305 , C12N9/1051 , C12P19/02 , C12P19/18 , C12P19/26 , C12P19/30
摘要： This invention relates to a process for producing a complex carbohydrate, which comprises: selecting, as enzyme sources, a culture broth of a microorganism capable of producing a sugar nucleotide from a nucleotide precursor and a sugar, or a treated product of the culture broth, and a culture broth of a microorganism or animal cell capable of producing a complex carbohydrate from a sugar nucleotide and a complex carbohydrate precursor, or a treated product of the culture broth; carrying out an enzyme reaction in an aqueous medium containing the enzyme sources, the nucleotide precursor, the sugar and the complex carbohydrate precursor to form and accumulate the complex carbohydrate in the aqueous medium; and recovering the complex carbohydrate from the aqueous medium, and a process for producing a sugar nucleotide, which comprises selecting, as an enzyme source, a culture broth of a microorganism capable of producing a sugar nucleotide from a nucleotide precursor and a sugar, or a treated product of the culture broth; carrying out an enzyme reaction in an aqueous medium containing the enzyme source, the nucleotide precursor and the sugar to form and accumulate the sugar nucleotide in the aqueous medium; and recovering the sugar nucleotide from the aqueous medium.
摘要翻译： 本发明涉及一种用于生产复合糖类，其包括：选择作为酶源，微生物的培养液中能够产生从核苷酸前体物质和糖，或该培养液的处理产物糖核苷酸的， 和能够产生从糖核苷酸和复合糖类前体，或该培养液的处理产物的复合碳水化合物的微生物或动物细胞的培养液; 在wässrige介质中进行酶反应在含有酶源，核苷酸前体物质，糖以及复合糖类前体以形成和积累在wässrige介质复合糖类; 并从该wässrige介质复合糖类，以及一种用于制造糖核苷酸的方法，包括选择，如在酶源，能够产生从核苷酸前体物质和糖，或糖核苷酸能力的微生物的培养液的处理 该培养液的处理产物; 进行在含有该酶源，核苷酸前体物质和糖以形成并积聚在wässrige介质中的糖核苷酸wässrige介质酶反应; 并从该介质wässrige糖核苷酸。
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公开(公告)号：EP0771876A1
公开(公告)日：1997-05-07
申请号：EP96905023.6
申请日：1996-03-07
发明人： OZAKI, Akio , MORI, Hideo , SHIBASAKI, Takeshi
CPC分类号： C12N9/0071 , C12P13/24
摘要： The present invention relates to industrial methods for producing cis-3-hydroxy-L-proline which is useful as a starting compound for medicines and an additive to foods, genes which code for L-proline 3-hydroxylases and which are useful for the above-mentioned process, recombinant DNA containing the gene, transformants containing the recombinant DNA, methods for producing L-proline 3-hydroxylases using the transformants and the enzyme.
摘要翻译： 本发明涉及可用作药物起始化合物和食品添加剂的顺式-3-羟基-L-脯氨酸的工业方法，其代表L-脯氨酸3-羟化酶的基因并且可用于上述 所述方法，含有该基因的重组DNA，含有重组DNA的转化体，使用转化体和酶产生L-脯氨酸3-羟化酶的方法。
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4.发明公开PROCESS FOR PRODUCING TRANS-4-HYDROXY-L-PROLINE 失效VERFAHREN ZUR HERSTELLUNG VON TRANS-4-HYDROXY-L-PROLIN
公开(公告)号：EP0759472A1
公开(公告)日：1997-02-26
申请号：EP96905024.4
申请日：1996-03-07
发明人： OZAKI, Akio , MORI, Hideo , SHIBASAKI, Takeshi
CPC分类号： C12N9/0071 , C12P13/24
摘要： The present invention relates to industrial methods for producing trans-4-hydroxy-L-proline which is useful as a starting compound for medicines and an additive to foods, genes which code for L-proline 4-hydroxylases and which are useful for the above-mentioned process, recombinant DNA containing the gene, transformants containing the recombinant DNA, methods for producing L-proline 4-hydroxylases using the transformants and the enzyme.
摘要翻译： 本发明涉及可用作药物起始化合物和食品添加剂的反式-4-羟基-L-脯氨酸的工业方法，其代表L-脯氨酸4-羟化酶并可用于上述物质 所述方法，含有该基因的重组DNA，含有重组DNA的转化体，使用转化体和酶产生L-脯氨酸4-羟化酶的方法。
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公开(公告)号：EP0185092A1
公开(公告)日：1986-06-25
申请号：EP85901555.4
申请日：1985-03-12
发明人： FUJIO, Tatsuro , MARUYAMA, Akihiko , NISHI, Tatsunari , OZAKI, Akio , ITO, Seiga , OZAKI, Atsuko
摘要： GMP can be prepared in a good yield by converting XMP, ammonia and/or L-glutamine in an aqueous solution using a culture product, cells or their treated product of E. coli having GMP synthetase activity and the ability of converting AMP to ATP in the presence of an energy source other than phosphorus oxides, in the presence of the energy source. GMP can also be prepared in a good yield by converting XMP, ammonia and/or L-glutamine to GMP in an aqueous medium in the presence of ATP using a culture product, cells or their treated product of transformant obtained by using a recombinant DNA of a DNA fragment containing GMP synthetase gene and a vector DNA fragment. The process of using transformant having ATP- reproducing ability is extremely advantageous.
摘要翻译： 通过使用培养产物，细胞或其具有GMP合成酶活性的大肠杆菌处理产物以及将AMP转化为ATP的能力，在水溶液中转化XMP，氨和/或L-谷氨酰胺，可以以良好的产率制备GMP 在能源存在的情况下存在除磷氧化物之外的能源。 通过使用培养产物，细胞或它们的转化体处理产物，在ATP存在下，在水性介质中将XMP，氨和/或L-谷氨酰胺转化为GMP，也可以以良好的产率制备GMP，所述转化体通过使用 含有GMP合成酶基因的DNA片段和载体DNA片段。 使用具有ATP再生能力的转化体的过程是非常有利的。
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6.发明授权
公开(公告)号：EP1020530B1
公开(公告)日：2008-03-12
申请号：EP98935282.8
申请日：1998-07-30
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公开(公告)号：EP0771876B1
公开(公告)日：2002-07-10
申请号：EP96905023.6
申请日：1996-03-07
发明人： OZAKI, Akio , MORI, Hideo , SHIBASAKI, Takeshi
CPC分类号： C12N9/0071 , C12P13/24
摘要： A process for industrially producing cis-3-hydroxy-L-proline which is useful as a material in the synthesis of drugs or a food additive; an L-proline 3-hydroxylase gene useful in this process; a recombinant DNA containing this gene; a transformant containing this recombinant DNA; a process for producing L-proline 3-hydroxilase with the use of this transformant; and this enzyme.
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公开(公告)号：EP0759472B1
公开(公告)日：2002-06-12
申请号：EP96905024.4
申请日：1996-03-07
发明人： OZAKI, Akio , MORI, Hideo , SHIBASAKI, Takeshi
CPC分类号： C12N9/0071 , C12P13/24
摘要： A process for industrially producing trans-4-hydroxy-L-proline which is useful as a material in the synthesis of drugs or a food additive; an L-proline 4-hydroxylase gene useful in this process; a recombinant DNA containing this gene; a transformant containing this recombinant DNA; L-proline 4-hydroxylase obtained with the use of this transformant; and this enzyme.
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9.发明公开N-ACETYLGLUCOSAMINE 2-EPIMERASE AND DNA ENCODING THE ENZYME 审中-公开N-ACETYLGLUCOSAMIN 2-EPIMERASE UND FUR DIESES ENZYM KODIERNDE DNA
公开(公告)号：EP1154018A1
公开(公告)日：2001-11-14
申请号：EP00902868.9
申请日：2000-02-09
发明人： KOIZUMI, Satoshi , TABATA, Kazuhiko , ENDO, Tetsuo , OZAKI, Akio
CPC分类号： C12P19/26 , C07K14/195 , C12N9/90
摘要： The present invention provides a novel protein having N -acetylglucosamine 2-epimerase activity; a DNA encoding the protein; a recombinant vector containing the DNA; a transformant obtainable by introducing the recombinant vector into a host cell; and a process for producing the protein or N -acetylmannosamine using the transformant.
摘要翻译： 本发明提供了具有N-乙酰葡糖胺2-差向异构酶活性的新型蛋白质; 编码蛋白质的DNA; 含有DNA的重组载体; 通过将重组载体导入宿主细胞获得的转化体; 以及使用该转化体生产蛋白质或N-乙酰甘露糖胺的方法。
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10.发明公开PROCESS FOR PRODUCING ISOPRENOID COMPOUNDS BY USING MICROORGANISMS AND METHOD FOR DETECTING COMPOUNDS HAVING ANTIBACTERIAL OR HERBICIDAL ACTIVITY 有权VERFAHREN ZUR HERSTELLUNG VON ISOPRENOIDVERBINDUNGEN DURCH MIKROORGANISMEN
公开(公告)号：EP1072683A1
公开(公告)日：2001-01-31
申请号：EP99913662.5
申请日：1999-04-14
发明人： MIYAKE, Koichiro, Kyowa Apartment C-3 , HASHIMOTO, Shinichi, LSP machida 1203 , MOTOYAMA, Hiroaki , OZAKI, Akio , SETO, Haruo , KUZUYAMA, Tomohisa , TAKAHASHI, Shunji, Greenhouse B 102
CPC分类号： C12N9/1085 , A01N63/02 , C12N9/0006 , C12N9/1022 , C12N15/52 , C12P7/66 , C12P23/00 , C12Q1/18 , C12Y202/01007 , G01N2430/20
摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.
摘要翻译： 本发明提供了使用含有一种或多种具有提高生物合成有效的心血管疾病，骨质疏松症，体内平衡，预防性药物的类异戊二烯化合物的生物合成能力的DNA编码蛋白质的DNA来生产类异戊二烯化合物或由DNA编码的蛋白质的方法 的癌症和免疫增强，保健食品和防污漆产品针对藤壶的DNA; 蛋白质; 以及用于筛选具有抗生素和除草活性的物质的方法，其包括在非甲羟戊酸途径上筛选抑制酶反应的物质。
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