-
1.发明公开PROCESS FOR THE PREPARATION OF HMG-CoA REDUCTASE INHIBITORS 失效VERFAHRENFÜRDIE HERSTELLUNG VON INHIBITOREN DER HMG-CoA-REDUKTASE。
公开(公告)号：EP1020530A1
公开(公告)日：2000-07-19
申请号：EP98935282.8
申请日：1998-07-30
发明人： TAKANO, Yutaka , HASEGAWA, Masaru , MORI, Hideo , ANDO, Katsuhiko , OCHIAI, Keiko , MOTOYAMA, Hiroaki , OZAKI, Akio
摘要： Disclosed is a process for producing a compound represented by general formula (II-a):
(wherein R 1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R 2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (II-a)] or the lactone form of Compound (II-a) [hereinafter referred to as Compound (II-b)] which comprises subjecting a compound represented by general formula (I-a):
(wherein R 1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R 2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (I-a)] or the lactone form of Compound (I-a) [hereinafter referred to as Compound (I-b)] to the action of an enzyme source derived from a microorganism belonging to the genus Bacillus and capable of converting Compound (I-a) or Compound (I-b) into Compound (II-a) or Compound (II-b) in a reaction mixture to form Compound (II-a) or Compound (II-b) in the reaction mixture, and recovering Compound (II-a) or Compound (II-b) from the reaction mixture.摘要翻译： 公开了通式（II-a）表示的化合物的制备方法：其中R 1表示氢原子，取代或未取代的烷基或碱金属，R 2表示 取代或未取代的烷基或芳基）在下文中称为化合物（II-a）Ü或化合物（II-a）的内酯形式，以下称为化合物（II-b）Ü，其包括使通式 式（Ia）：
（其中R 1表示氢原子，取代或未取代的烷基或碱金属; R 2表示取代或未取代的烷基或芳基）在下文中 化合物（Ia）或化合物（Ia）的内酯形式以下称为化合物（Ib）ü来源于属于芽孢杆菌属的微生物的酶源的作用，并能够将化合物（Ia）或化合物（ Ib）化合物（II-a）或化合物（II-b）反应 离子混合物在反应混合物中形成化合物（II-a）或化合物（II-b），并从反应混合物中回收化合物（II-a）或化合物（II-b）。 -
2.发明授权
公开(公告)号：EP1020530B1
公开(公告)日：2008-03-12
申请号：EP98935282.8
申请日：1998-07-30
-
搜索结果
2 条记录 (耗时 0.01 秒)
