发明授权
- 专利标题： MODULATING MULTIPLE LINEAGE KINASE PROTEINS
- 专利标题（中）： MLK-调制（多LINEAGE激酶）蛋白
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申请号： EP99943759.3申请日： 1999-08-18
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公开(公告)号： EP1105728B1公开(公告)日： 2005-04-13
- 发明人: MARONEY, Anna , WALTON, Kevin, M. , DIONNE, Craig, A. , NEFF, Nicola , KNIGHT, Ernest, Jr. , GLICKSMAN, Marcie, A.
- 申请人： CEPHALON, INC.
- 申请人地址： 145 Brandywine Parkway West Chester, PA 19380 US
- 专利权人： CEPHALON, INC.
- 当前专利权人： CEPHALON, INC.
- 当前专利权人地址： 145 Brandywine Parkway West Chester, PA 19380 US
- 代理机构： Hallybone, Huw George
- 优先权： US97980P 19980826
- 国际公布： WO2000013015 20000309
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; C12Q1/68 ; G01N33/68 ; A61K31/40 ; A61K31/535 ; A61K31/55
摘要：
Methods for identifying compounds which modulate activity of a multiple lineage kinase protein and promotes cell survival or cell death comprising the steps of contacting the cell containing the multiple lineage kinase protein with the compound, determining whether the compound decreases activity of the multiple lineage kinase protein, and determining whether the compound promotes cell survival are provided. Methods for identifying compounds which may be useful in the treatment of neurodegenerative disorders and/or inflammation are also provided. Methods for modulating the activity of a multiple lineage kinase protein comprising contacting the protein or a cell containing the protein with an indeno- or indolo- compound of the invention are also provided. Methods of treating neurodegenerative disorders and/or inflammation are also provided.
公开/授权文献
- EP1105728A1 MODULATING MULTIPLE LINEAGE KINASE PROTEINS 公开/授权日：2001-06-13
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