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公开(公告)号：EP1105728A1
公开(公告)日：2001-06-13
申请号：EP99943759.3
申请日：1999-08-18
申请人： CEPHALON, INC.
发明人： MARONEY, Anna , WALTON, Kevin, M. , DIONNE, Craig, A. , NEFF, Nicola , KNIGHT, Ernest, Jr. , GLICKSMAN, Marcie, A.
CPC分类号： G01N33/6896 , C12Q1/48 , G01N2333/9121
摘要： Methods for identifying compounds which modulate activity of a multiple lineage kinase protein and promotes cell survival or cell death comprising the steps of contacting the cell containing the multiple lineage kinase protein with the compound, determining whether the compound decreases activity of the multiple lineage kinase protein, and determining whether the compound promotes cell survival are provided. Methods for identifying compounds which may be useful in the treatment of neurodegenerative disorders and/or inflammation are also provided. Methods for modulating the activity of a multiple lineage kinase protein comprising contacting the protein or a cell containing the protein with an indeno- or indolo- compound of the invention are also provided. Methods of treating neurodegenerative disorders and/or inflammation are also provided.
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2.发明公开FUSED PYRROLO(2,3-C)CARBAZOLE-6-ONES WHICH POTENTIATE ACTIVITY OF GAMMA INTERFERON 失效简明吡咯并（2,3-C）咔唑-6-酮γ-干扰素增强的活性
公开(公告)号：EP0885229A1
公开(公告)日：1998-12-23
申请号：EP97914792.0
申请日：1997-02-20
申请人： CEPHALON, INC.
CPC分类号： C07D487/04 , C07D487/14 , C07D493/14 , C07D495/14
摘要： Disclosed in this patent document are synthetic, biologically active molecules referred to as fused pyrrolo(2,3-c)carbazole-6-ones. These molecules are represented by general formulae (I) and (II). Methods for making and using the fused pyrrolo(2,3-c)carbazole-6-ones are also disclosed.
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公开(公告)号：EP1105728B1
公开(公告)日：2005-04-13
申请号：EP99943759.3
申请日：1999-08-18
申请人： CEPHALON, INC.
发明人： MARONEY, Anna , WALTON, Kevin, M. , DIONNE, Craig, A. , NEFF, Nicola , KNIGHT, Ernest, Jr. , GLICKSMAN, Marcie, A.
CPC分类号： G01N33/6896 , C12Q1/48 , G01N2333/9121
摘要： Methods for identifying compounds which modulate activity of a multiple lineage kinase protein and promotes cell survival or cell death comprising the steps of contacting the cell containing the multiple lineage kinase protein with the compound, determining whether the compound decreases activity of the multiple lineage kinase protein, and determining whether the compound promotes cell survival are provided. Methods for identifying compounds which may be useful in the treatment of neurodegenerative disorders and/or inflammation are also provided. Methods for modulating the activity of a multiple lineage kinase protein comprising contacting the protein or a cell containing the protein with an indeno- or indolo- compound of the invention are also provided. Methods of treating neurodegenerative disorders and/or inflammation are also provided.
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公开(公告)号：EP1309721A2
公开(公告)日：2003-05-14
申请号：EP01961958.4
申请日：2001-08-08
申请人： CEPHALON, INC.
发明人： MARONEY, Anna , WALTON, Kevin, M. , DIONNE, Craig, A. , NEFF, Nicola , KNIGHT, Ernest, Jr. , GLICKSMAN, Marcie, A.
CPC分类号： G01N33/56988 , A61K31/40 , C12Q1/485 , G01N33/6896
摘要： Methods for identifying compounds which modulate activity of a multiple linease kinase protein and promotes cell survival or cell death comprising the steps of contacting the cell containing the multiple linease protein with the compound, determining whether the compound decreases activity of the multiple linease protein, and determining whether the compound promotes cell survival are provided. Methods for identifying compounds which may be useful in the treatment of neurodegenerative disorders and/or inflammation are also provided. Methods for modulating the activity of a multiple linage kinase protein comprising contacting the protein or a cell containing the protein with an indeno- or indolo-compound of the invention are also provided. Methods of treating nuerodegenerative disorders and/or inflammation are also provided
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5.发明授权USE OF K-252A DERIVATIVE FOR THE TREATMENT OF PERIPHERAL OR CENTRAL NERVE DISORDERS, AND CYTOKINE OVERPRODUCTION 失效K-252A衍生物的用于外周神经疾病与过量细胞素的中枢神经治疗或用途
公开(公告)号：EP0912184B1
公开(公告)日：2002-09-25
申请号：EP97930203.1
申请日：1997-06-24
申请人： CEPHALON, INC.
发明人： ENGBER, Thomas, M. , HAUN, Forrest, A. , SAPORITO, Michael, S. , AIMONE, Lisa, D. , MILLER, Matthew, S. , KNIGHT, Ernest, Jr.
CPC分类号： A61K31/554 , A61K31/55 , A61K31/553
摘要： Disclosed herein are therapeutic methodologies utilizing a ring substituted derivative of the indolocarbazole K252a, the derivative represented by the formula (A). The compound is useful for treating peripheral neuropathies, central neuronal degeneration and cytokine overproduction. Typical diseases related to the above are peripheral neuropathy, Alzheimer's disease, Parkinson's disease and autoimmune and allergic conditions.
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公开(公告)号：EP0785938B1
公开(公告)日：2002-01-02
申请号：EP95938713.5
申请日：1995-10-03
申请人： CEPHALON, INC.
IPC分类号： C07D487/04 , C07D495/14 , C07D491/14 , A61K31/40 , C07D471/14
CPC分类号： C07D487/04 , C07D491/14 , C07D495/14
摘要： Disclosed herein are compounds referred to as 'fused pyrrolocarbazoles' which possess a variety of functional pharmacological activities including effect on the function and/or survival of trophic factor responsive cells; inhibition of enzymatic activity; inhibition of inflammation-associated responses; inhibition of cell growth associated with hyperproliferative states; and inhibition of developmentally programmed mononeuron death. The disclosed compounds are represented by general formula (G). Methodologies for the synthetic production of fused pyrrolocabazoles are also disclosed, as well as exemplary uses of the compounds.
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7.发明授权FUSED PYRROLO(2,3-C)CARBAZOLE-6-ONES WHICH POTENTIATE ACTIVITY OF GAMMA INTERFERON 失效简明吡咯并（2,3-C）咔唑-6-酮γ-干扰素增强的活性
公开(公告)号：EP0885229B1
公开(公告)日：2000-08-02
申请号：EP97914792.3
申请日：1997-02-20
申请人： CEPHALON, INC.
IPC分类号： C07D491/14 , C07D495/14 , C07D487/14 , C07D487/04 , A61K31/40
CPC分类号： C07D487/04 , C07D487/14 , C07D493/14 , C07D495/14
摘要： Disclosed in this patent document are synthetic, biologically active molecules referred to as fused pyrrolo(2,3-c)carbazole-6-ones. These molecules are represented by general formulae (I) and (II). Methods for making and using the fused pyrrolo(2,3-c)carbazole-6-ones are also disclosed.
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8.发明公开USE OF K-252A DERIVATIVE FOR THE TREATMENT OF PERIPHERAL OR CENTRAL NERVE DISORDERS, AND CYTOKINE OVERPRODUCTION 失效K-252A衍生物的用于外周神经疾病与过量细胞素的中枢神经治疗或用途
公开(公告)号：EP0912184A1
公开(公告)日：1999-05-06
申请号：EP97930203.0
申请日：1997-06-24
申请人： CEPHALON, INC.
发明人： ENGBER, Thomas, M. , HAUN, Forrest, A. , SAPORITO, Michael, S. , AIMONE, Lisa, D. , MILLER, Matthew, S. , KNIGHT, Ernest, Jr.
CPC分类号： A61K31/554 , A61K31/55 , A61K31/553
摘要： Disclosed herein are therapeutic methodologies utilizing a ring substituted derivative of the indolocarbazole K252a, the derivative represented by the formula (A). The compound is useful for treating peripheral neuropathies, central neuronal degeneration and cytokine overproduction. Typical diseases related to the above are peripheral neuropathy, Alzheimer's disease, Parkinson's disease and autoimmune and allergic conditions.
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公开(公告)号：EP0785938A1
公开(公告)日：1997-07-30
申请号：EP95938713.0
申请日：1995-10-03
申请人： CEPHALON, INC.
CPC分类号： C07D487/04 , C07D491/14 , C07D495/14
摘要： Disclosed herein are compounds referred to as 'fused pyrrolocarbazoles' which possess a variety of functional pharmacological activities including effect on the function and/or survival of trophic factor responsive cells; inhibition of enzymatic activity; inhibition of inflammation-associated responses; inhibition of cell growth associated with hyperproliferative states; and inhibition of developmentally programmed mononeuron death. The disclosed compounds are represented by general formula (G). Methodologies for the synthetic production of fused pyrrolocabazoles are also disclosed, as well as exemplary uses of the compounds.
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