发明公开
EP1116716A1 Piperidine and piperazine compounds for use in the treatment of Alzheimer
失效
Piperidin-和Piperazinverbindungen zur Verwendung in der Behandlung von Alzheimer
- 专利标题： Piperidine and piperazine compounds for use in the treatment of Alzheimer
- 专利标题（中）： Piperidin-和Piperazinverbindungen zur Verwendung in der Behandlung von Alzheimer
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申请号： EP01102878.4申请日： 1988-06-22
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公开(公告)号： EP1116716A1公开(公告)日： 2001-07-18
- 发明人: Sugitomo, Hachiro , Tsuchiya, Yutaka , Higurashi, Kunizou , Karibe, Norio , Iimura, Youichi , Sasaki, Atsushi , Yamanishi, Yoshiharu , Ogura, Hiroo , Araki, Shin , Kosasa, Takashi , Kusota, Atsuhiko , Kosasa, Michiko , Yamatsu, Kiyomi
- 申请人： Eisai Co., Ltd.
- 申请人地址： 6-10, Koishikawa 4-chome Bunkyo-ku Tokyo 112-0002 JP
- 专利权人： Eisai Co., Ltd.
- 当前专利权人： Eisai Co., Ltd.
- 当前专利权人地址： 6-10, Koishikawa 4-chome Bunkyo-ku Tokyo 112-0002 JP
- 代理机构： HOFFMANN - EITLE
- 优先权： JP15505887 19870622
- 主分类号： C07D211/22
- IPC分类号： C07D211/22 ; C07D211/26 ; C07D211/76 ; C07D211/34 ; C07D207/09 ; C07D401/06 ; C07D401/12 ; C07D405/12 ; A61K31/445 ; A61P25/28
摘要：
A cyclic amine compound or a salt thereof is defined by the formula:
in which J is
(a) an optionally substituted group selected from (1) phenyl, (2) pyridyl, (3) pyrazyl, (4) quinolyl, (5) cyclohexyl, (6) quinoxalyl and (7) furyl;
(b) a monovalent or divalent group, in which the phenyl may have a substituent(s) selected from the group consisting of (1) indanyl, (2) indanonyl, (3) indenyl, (4) indenonyl, (5) indanedionyl, (6) tetralonyl, (7) benzosuberonyl, (8) indanolyl and (9) C 6 H 5 -CO-CH(CH 3 )-;
(c) a monovalent group derived from a cyclic amide compound;
(d) a lower alkyl; or
(e) a group of R 21 -CH=CH- in which R 21 is hydrogen or a lower alkoxycarbonyl;
B is a bridging group;
T is a nitrogen;
Q is nitrogen, carbon or >N→0;
q is an integer of 1 to 3;
K is hydrogen, an optionally substituted phenyl group, an arylalkyl in which the phenyl may have a substituent, cynnamyl, a lower alkyl, pyridylmethyl, a cycloalkylalkyl, adamantanemethyl, furylmethyl, a cycloalkyl, a lower alkoxycarbonyl or an acyl; and
---- ¯ shows a single bond or a double bond.
The compound is useful for the preparation of pharmaceutical compositions and for medicaments effective against senile dementia.
in which J is
(a) an optionally substituted group selected from (1) phenyl, (2) pyridyl, (3) pyrazyl, (4) quinolyl, (5) cyclohexyl, (6) quinoxalyl and (7) furyl;
(b) a monovalent or divalent group, in which the phenyl may have a substituent(s) selected from the group consisting of (1) indanyl, (2) indanonyl, (3) indenyl, (4) indenonyl, (5) indanedionyl, (6) tetralonyl, (7) benzosuberonyl, (8) indanolyl and (9) C 6 H 5 -CO-CH(CH 3 )-;
(c) a monovalent group derived from a cyclic amide compound;
(d) a lower alkyl; or
(e) a group of R 21 -CH=CH- in which R 21 is hydrogen or a lower alkoxycarbonyl;
B is a bridging group;
T is a nitrogen;
Q is nitrogen, carbon or >N→0;
q is an integer of 1 to 3;
K is hydrogen, an optionally substituted phenyl group, an arylalkyl in which the phenyl may have a substituent, cynnamyl, a lower alkyl, pyridylmethyl, a cycloalkylalkyl, adamantanemethyl, furylmethyl, a cycloalkyl, a lower alkoxycarbonyl or an acyl; and
---- ¯ shows a single bond or a double bond.
The compound is useful for the preparation of pharmaceutical compositions and for medicaments effective against senile dementia.
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