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    Piperidine and piperazine compounds for use in the treatment of Alzheimer
    6.
    发明公开
    Piperidine and piperazine compounds for use in the treatment of Alzheimer 失效
    Piperidin-和Piperazinverbindungen zur Verwendung in der Behandlung von Alzheimer

    公开(公告)号：EP1116716A1

    公开(公告)日：2001-07-18

    申请号：EP01102878.4

    申请日：1988-06-22

    申请人： Eisai Co., Ltd.

    发明人： Sugitomo, Hachiro ,  Tsuchiya, Yutaka ,  Higurashi, Kunizou ,  Karibe, Norio ,  Iimura, Youichi ,  Sasaki, Atsushi ,  Yamanishi, Yoshiharu ,  Ogura, Hiroo ,  Araki, Shin ,  Kosasa, Takashi ,  Kusota, Atsuhiko ,  Kosasa, Michiko ,  Yamatsu, Kiyomi

    IPC分类号： C07D211/22 ,  C07D211/26 ,  C07D211/76 ,  C07D211/34 ,  C07D207/09 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  A61K31/445 ,  A61P25/28

    CPC分类号： C07D401/06 ,  C07D207/09 ,  C07D211/22 ,  C07D211/26 ,  C07D211/28 ,  C07D211/32 ,  C07D211/34 ,  C07D211/44 ,  C07D211/70 ,  C07D211/76 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D413/06 ,  C07D471/04 ,  Y10S152/90

    摘要： A cyclic amine compound or a salt thereof is defined by the formula:
    in which J is

    (a) an optionally substituted group selected from (1) phenyl, (2) pyridyl, (3) pyrazyl, (4) quinolyl, (5) cyclohexyl, (6) quinoxalyl and (7) furyl;
    (b) a monovalent or divalent group, in which the phenyl may have a substituent(s) selected from the group consisting of (1) indanyl, (2) indanonyl, (3) indenyl, (4) indenonyl, (5) indanedionyl, (6) tetralonyl, (7) benzosuberonyl, (8) indanolyl and (9) C 6 H 5 -CO-CH(CH 3 )-;
    (c) a monovalent group derived from a cyclic amide compound;
    (d) a lower alkyl; or
    (e) a group of R 21 -CH=CH- in which R 21 is hydrogen or a lower alkoxycarbonyl;
    B is a bridging group;
    T is a nitrogen;
    Q is nitrogen, carbon or >N→0;
    q is an integer of 1 to 3;
    K is hydrogen, an optionally substituted phenyl group, an arylalkyl in which the phenyl may have a substituent, cynnamyl, a lower alkyl, pyridylmethyl, a cycloalkylalkyl, adamantanemethyl, furylmethyl, a cycloalkyl, a lower alkoxycarbonyl or an acyl; and
    ---- ¯ shows a single bond or a double bond.

    The compound is useful for the preparation of pharmaceutical compositions and for medicaments effective against senile dementia.

    摘要翻译： 环胺化合物或其盐由下式定义：其中J为（a）任选取代的基团，其选自（1）苯基，（2）吡啶基，（3）吡嗪基，（4）喹啉基，（5） 环己基，（6）喹喔啉基和（7）呋喃基; （b）一价或二价基团，其中苯基可以具有选自（1）茚满基，（2）茚满基，（3）茚基，（4）茚基，（5）茚满基， ，（6）四氢萘酮，（7）苯并四氢呋喃基，（8）茚满基和（9）C 6 H 5 -CO-CH（CH 3） - 。 （c）衍生自环状酰胺化合物的一价基团; （d）低级烷基; 或（e）R 21 -CH = CH-的基团，其中R 21是氢或低级烷氧基羰基; B是桥接组; T是氮; Q是氮，碳或> N-> 0; q为1〜3的整数， K是氢，任选取代的苯基，其中苯基可以具有取代基的芳基烷基，炔基，低级烷基，吡啶基甲基，环烷基烷基，金刚烷甲基，呋喃基甲基，环烷基，低级烷氧基羰基或酰基; 并显示单一债券或双重债券。 该化合物可用于制备药物组合物和对老年痴呆有效的药物。