发明授权
EP1124804B1 PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS
有权
前列腺素合成酶生物合成抑制剂ENDOPEROXYDE ^ h
- 专利标题： PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS
- 专利标题（中）： 前列腺素合成酶生物合成抑制剂ENDOPEROXYDE ^ h
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申请号： EP99953259.1申请日： 1999-10-27
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公开(公告)号： EP1124804B1公开(公告)日： 2005-08-24
- 发明人: BLACK, Lawrence, A. , BASHA, Anwer , KOLASA, Teodozyj , KORT, Michael, E. , LIU, Huaqing , MCCARTY, Catherine, M. , PATEL, Meena, V. , ROHDE, Jeffrey, J. , COGHLAN, Michael, J. , STEWART, Andrew, O.
- 申请人： ABBOTT LABORATORIES
- 申请人地址： CHAD 0377/AP6D-2, 100 Abbott Park Road Abbott Park, IL 60064-6050 US
- 专利权人： ABBOTT LABORATORIES
- 当前专利权人： ABBOTT LABORATORIES
- 当前专利权人地址： CHAD 0377/AP6D-2, 100 Abbott Park Road Abbott Park, IL 60064-6050 US
- 代理机构： Modiano, Guido
- 优先权： US179605 19981027; US261872 19990303; US298490 19990423; US427768 19991027
- 国际公布： WO2000024719 20000504
- 主分类号： C07D237/14
- IPC分类号： C07D237/14 ; A61K31/50 ; C07D405/04 ; C07D409/04
摘要：
The present invention describes pyridazinone compounds of formula (I) which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important 'housekeeping' enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectively of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).
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