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1.发明公开
公开(公告)号：EP1124804A1
公开(公告)日：2001-08-22
申请号：EP99953259.1
申请日：1999-10-27
申请人： ABBOTT LABORATORIES
发明人： BLACK, Lawrence, A. , BASHA, Anwer , KOLASA, Teodozyj , KORT, Michael, E. , LIU, Huaqing , MCCARTY, Catherine, M. , PATEL, Meena, V. , ROHDE, Jeffrey, J. , COGHLAN, Michael, J. , STEWART, Andrew, O.
IPC分类号： C07D237/14 , A61K31/50 , C07D405/04 , C07D409/04
CPC分类号： C07D405/04 , C07D237/14 , C07D409/04
摘要： The present invention describes pyridazinone compounds of formula (I) which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important 'housekeeping' enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectively of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).
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2.发明公开GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS 有权GLUCOCORTICOID SELEKTIVEENTZÜNDUNGSHEMMENDEMITTEL
公开(公告)号：EP1100483A2
公开(公告)日：2001-05-23
申请号：EP99938896.0
申请日：1999-07-30
申请人： Abbott Laboratories
IPC分类号： A61K31/136 , A61K31/137 , A61K31/167 , A61K31/4545 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/4025 , A61K31/222 , A61K31/40 , A61K31/45 , A61K31/24 , A61K31/341 , C07D295/06 , C07C219/06 , C07C211/52 , C07C215/16 , C07C271/28 , C07C219/10 , C07C217/76 , C07C323/29
CPC分类号： C07C211/52 , C07C211/50 , C07C215/16 , C07C217/76 , C07C217/80 , C07C219/06 , C07C229/18 , C07C233/43 , C07C233/44 , C07C233/62 , C07C233/80 , C07C271/28 , C07C311/39 , C07C323/29 , C07C2601/02 , C07D317/48
摘要： Compounds having Formula (I) are useful for modulating the glucocorticoid receptor in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I) and methods of treating immune, autoimmune, inflammatory, adrenal imbalance, cognitive and behavioral diseases in a mammal.
摘要翻译： 具有式（I）的化合物可用于调节哺乳动物中的糖皮质激素受体。 还公开了包含式（I）的化合物的药物组合物和在哺乳动物中治疗免疫，自身免疫，炎性，肾上腺不平衡，认知和行为疾病的方法。
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3.发明授权
公开(公告)号：EP1124804B1
公开(公告)日：2005-08-24
申请号：EP99953259.1
申请日：1999-10-27
申请人： ABBOTT LABORATORIES
发明人： BLACK, Lawrence, A. , BASHA, Anwer , KOLASA, Teodozyj , KORT, Michael, E. , LIU, Huaqing , MCCARTY, Catherine, M. , PATEL, Meena, V. , ROHDE, Jeffrey, J. , COGHLAN, Michael, J. , STEWART, Andrew, O.
IPC分类号： C07D237/14 , A61K31/50 , C07D405/04 , C07D409/04
CPC分类号： C07D405/04 , C07D237/14 , C07D409/04
摘要： The present invention describes pyridazinone compounds of formula (I) which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important 'housekeeping' enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectively of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).
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公开(公告)号：EP1100483B1
公开(公告)日：2004-09-29
申请号：EP99938896.0
申请日：1999-07-30
申请人： Abbott Laboratories
IPC分类号： A61K31/136 , A61K31/137 , A61K31/167 , A61K31/4545 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/4025 , A61K31/222 , A61K31/40 , A61K31/45 , A61K31/24 , A61K31/341 , C07D295/06 , C07C219/06 , C07C211/52 , C07C215/16 , C07C271/28 , C07C219/10 , C07C217/76 , C07C323/29
CPC分类号： C07C211/52 , C07C211/50 , C07C215/16 , C07C217/76 , C07C217/80 , C07C219/06 , C07C229/18 , C07C233/43 , C07C233/44 , C07C233/62 , C07C233/80 , C07C271/28 , C07C311/39 , C07C323/29 , C07C2601/02 , C07D317/48
摘要： Compounds having Formula (I) are useful for modulating the glucocorticoid receptor in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I) and methods of treating immune, autoimmune, inflammatory, adrenal imbalance, cognitive and behavioral diseases in a mammal.
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