发明公开
- 专利标题： TRICYCLIC FARNESYL PROTEIN TRANSFERASE INHIBITORS
- 专利标题（中）： 三环类法尼酯蛋白转移酶抑制剂
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申请号： EP99963980.0申请日： 1999-12-16
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公开(公告)号： EP1140902A1公开(公告)日： 2001-10-10
- 发明人: TAVERAS, Arthur, G. , DOLL, Ronald, J. , COOPER, Alan, B. , FERREIRA, Johan, A. , GUZI, Timothy , MALLAMS, Alan, K. , RANE, Dinanath, F. , GIRIJAVALLABHAN, Viyyoor, M. , AFONSO, Adriano , AKI, Cynthia, J. , CHAO, Jianping , ALVAREZ, Carmen , KELLY, Joseph, M. , LALWANI, Tarik , DESAI, Jagdish, A. , WANG, James, J., S. , WEINSTEIN, Jay
- 申请人： SCHERING CORPORATION
- 申请人地址： 2000 Galloping Hill Road Kenilworth,New Jersey 07033-0530 US
- 专利权人： SCHERING CORPORATION
- 当前专利权人： SCHERING CORPORATION
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth,New Jersey 07033-0530 US
- 代理机构： Ritter, Stephen David
- 优先权： US216398 19981218
- 国际公布： WO0037459 20000629
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; C07D413/14 ; C07D407/14 ; A61K31/445 ; A61K31/44 ; A61K31/55 ; A61P35/00
摘要：
Disclosed are compounds of formula (1.0) wherein R13 represents an imidazole ring; R14 represents a carbamate, urea, amide or sulfonamide group; R8 represents H when the alkyl chain between the amide group and the R13 imidazole group is substituted, or R8 represents a substituent such aa arylalkyl, heteroarylalkyl or cycloalkyl; and the remaining substituents are as defined herein. Also disclosed are compounds wherein R8 is H, and the alkyl chain between the amide group and the R13 imidazole group is unsubstituted. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
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