公开(公告)号：EP1140909A1

公开(公告)日：2001-10-10

申请号：EP99965906.3

申请日：1999-12-22

申请人： SCHERING CORPORATION ,  PHARMACOPEIA, INC.

发明人： COOPER, Alan, B. ,  DOLL, Ronald, J. ,  FERREIRA, Johan, A. ,  GANGULY, Ashit ,  GIRIJAVALLABHAN, Viyyoor, M. ,  TAVERAS, Arthur, G. ,  CHAO, Jianping ,  BALDWIN, John, J. ,  HUANG, Chia-Yu ,  LI, Ge

IPC分类号： C07D403/12 ,  C07D401/14 ,  C07D241/04 ,  A61K31/496 ,  A61P35/00

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D241/04 ,  C07D249/08 ,  C07D401/14 ,  C07D403/12

摘要： Novel compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl-protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.

公开(公告)号：EP1381590B1

公开(公告)日：2007-06-20

申请号：EP02739172.1

申请日：2002-04-15

申请人： SCHERING CORPORATION ,  Pharmacopeia Drug Discovery, Inc.

发明人： TAVERAS, Arthur, G. ,  AKI, Cynthia, J. ,  BOND, Richard, W. ,  CHAO, Jianping ,  DWYER, Michael ,  FERREIRA, Johan, A. ,  CHAO, Jianhua ,  YU, Younong ,  BALDWIN, John, J. ,  KAISER, Bernd ,  LI, Ge ,  MERRITT, J., Robert ,  NELSON, Kingsley, H. ,  ROKOSZ, Laura, L.

IPC分类号： C07C237/30 ,  C07C255/59 ,  C07C225/20 ,  C07D213/74 ,  C07D307/52 ,  C07D333/36

CPC分类号： C07D231/38 ,  C07C225/20 ,  C07C237/30 ,  C07C255/59 ,  C07C2601/04 ,  C07D213/74 ,  C07D307/52 ,  C07D333/36

摘要： There are disclosed compounds of Formula (I) or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

摘要翻译： 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的具有下式的化合物或其药学上可接受的盐或溶剂合物。

公开(公告)号：EP1381590A1

公开(公告)日：2004-01-21

申请号：EP02739172.1

申请日：2002-04-15

申请人： Schering Corporation ,  PHARMACOPEIA, INC.

发明人： TAVERAS, Arthur, G. ,  AKI, Cynthia, J. ,  BOND, Richard, W. ,  CHAO, Jianping ,  DWYER, Michael ,  FERREIRA, Johan, A. ,  CHAO, Jianhua ,  YU, Younong ,  BALDWIN, John, J. ,  KAISER, Bernd ,  LI, Ge ,  MERRITT, J., Robert ,  NELSON, Kingsley, H. ,  ROKOSZ, Laura, L.

IPC分类号： C07C237/30 ,  C07C255/59 ,  C07C225/20 ,  C07D213/74 ,  C07D307/52 ,  C07D333/36

CPC分类号： C07D231/38 ,  C07C225/20 ,  C07C237/30 ,  C07C255/59 ,  C07C2601/04 ,  C07D213/74 ,  C07D307/52 ,  C07D333/36

摘要： There are disclosed compounds of Formula (I) or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

公开(公告)号：EP1140909B1

公开(公告)日：2005-07-06

申请号：EP99965906.3

申请日：1999-12-22

申请人： Schering Corporation ,  Pharmacopeia Drug Discovery, Inc.

发明人： COOPER, Alan, B. ,  DOLL, Ronald, J. ,  FERREIRA, Johan, A. ,  GANGULY, Ashit ,  GIRIJAVALLABHAN, Viyyoor, M. ,  TAVERAS, Arthur, G. ,  CHAO, Jianping ,  BALDWIN, John, J. ,  HUANG, Chia-Yu ,  LI, Ge

IPC分类号： C07D403/12 ,  C07D401/14 ,  C07D241/04 ,  A61K31/496 ,  A61P35/00

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D241/04 ,  C07D249/08 ,  C07D401/14 ,  C07D403/12

摘要： Novel compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl-protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.

公开(公告)号：EP1434775A1

公开(公告)日：2004-07-07

申请号：EP02786395.0

申请日：2002-10-11

申请人： Schering Corporation ,  PHARMACOPEIA, INC.

发明人： TAVERAS, Arthur, G. ,  DWYER, Michael ,  FERREIRA, Johan, A. ,  GIRIJAVALLABHAN, Viyyoor, M. ,  CHAO, Jianping ,  BALDWIN, John, J. ,  MERRITT, J., Robert ,  LI, Ge

IPC分类号： C07D409/12 ,  C07D405/12 ,  C07D207/44 ,  C07D401/08 ,  C07D403/12 ,  C07D401/12 ,  C07D409/14 ,  C07D417/12 ,  A61K31/4015 ,  A61K31/4025 ,  A61P35/00

CPC分类号： C07D207/456 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12

摘要： Disclosed are compounds of the formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

公开(公告)号：EP1355875A1

公开(公告)日：2003-10-29

申请号：EP02731085.3

申请日：2002-02-01

申请人： SCHERING CORPORATION ,  PHARMACOPEIA, INC.

发明人： TAVERAS, Arthur, G. ,  AKI, Cynthia, J., ,  BOND, Richard, W. ,  CHAO, Jianping ,  DWYER, Michael ,  FERREIRA, Johan, A. ,  PACHTER, Jonathan ,  BALDWIN, John, J. ,  KAISER, Bernd ,  LI, Ge ,  MERRITT, J., Robert ,  NELSON, Kingsley, H., Jr. ,  ROKOSZ, Laura, L.

IPC分类号： C07C225/20 ,  C07C229/42 ,  C07C229/64 ,  C07C237/36 ,  C07C237/44 ,  C07C255/58 ,  C07C255/59 ,  C07C271/20 ,  C07C311/08 ,  C07C311/21 ,  C07D205/04 ,  C07D207/08 ,  C07D207/16 ,  C07D211/60 ,  C07D213/89 ,  C07D231/38 ,  C07D235/06 ,  C07D239/42 ,  C07D249/18 ,  C07D277/28 ,  C07D285/08

CPC分类号： C07D207/08 ,  C07C225/20 ,  C07C229/42 ,  C07C229/64 ,  C07C237/36 ,  C07C237/44 ,  C07C255/59 ,  C07C271/20 ,  C07C311/08 ,  C07C311/21 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2602/10 ,  C07D205/04 ,  C07D207/16 ,  C07D211/60 ,  C07D213/74 ,  C07D213/89 ,  C07D231/38 ,  C07D235/06 ,  C07D239/42 ,  C07D249/18 ,  C07D277/28 ,  C07D277/42 ,  C07D285/08 ,  C07D295/13 ,  C07D295/135 ,  C07D295/192 ,  C07D295/205 ,  C07D317/66 ,  C07D333/38

摘要： There are disclosed compounds of formula (I) wherein the variables A and B are an aryl or heteroaryl group as defined in the claims, or a prodrug thereof, or a pharmaceutically acceptable salt, solvate or isomer of said compound or of said prodrug, which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

摘要翻译： 公开了下式的化合物其前药，或所述化合物或所述前药的药学上可接受的盐，溶剂合物或异构体，其可用于治疗趋化因子介导的疾病，例如急性和慢性炎症性疾病和癌症。

公开(公告)号：EP1140902A1

公开(公告)日：2001-10-10

申请号：EP99963980.0

申请日：1999-12-16

申请人： SCHERING CORPORATION

发明人： TAVERAS, Arthur, G. ,  DOLL, Ronald, J. ,  COOPER, Alan, B. ,  FERREIRA, Johan, A. ,  GUZI, Timothy ,  MALLAMS, Alan, K. ,  RANE, Dinanath, F. ,  GIRIJAVALLABHAN, Viyyoor, M. ,  AFONSO, Adriano ,  AKI, Cynthia, J. ,  CHAO, Jianping ,  ALVAREZ, Carmen ,  KELLY, Joseph, M. ,  LALWANI, Tarik ,  DESAI, Jagdish, A. ,  WANG, James, J., S. ,  WEINSTEIN, Jay

IPC分类号： C07D401/14 ,  C07D413/14 ,  C07D407/14 ,  A61K31/445 ,  A61K31/44 ,  A61K31/55 ,  A61P35/00

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D401/14

摘要： Disclosed are compounds of formula (1.0) wherein R13 represents an imidazole ring; R14 represents a carbamate, urea, amide or sulfonamide group; R8 represents H when the alkyl chain between the amide group and the R13 imidazole group is substituted, or R8 represents a substituent such aa arylalkyl, heteroarylalkyl or cycloalkyl; and the remaining substituents are as defined herein. Also disclosed are compounds wherein R8 is H, and the alkyl chain between the amide group and the R13 imidazole group is unsubstituted. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.

摘要翻译： 公开了式（1.0）的化合物，其中R 13代表咪唑环; R14代表氨基甲酸酯，脲，酰胺或磺酰胺基团; 当酰胺基团和R13咪唑基团之间的烷基链被取代时，R8表示H，或者R8表示取代基如芳烷基，杂芳基烷基或环烷基; 其余的取代基如本文所定义。 还公开了其中R 8为H且酰胺基团和R 13咪唑基团之间的烷基链未被取代的化合物。 还公开了使用所公开的化合物治疗癌症的方法和抑制法呢基蛋白转移酶的方法。