发明公开
EP1164838A4 SCREENING ASSAY FOR ANTAGONISTS OF FGFR-MEDIATED MALIGNANT CELL TRANSFORMATION AND TUMOR FORMATION
审中-公开
筛选分析用于拮抗剂FGFR依赖的细胞恶性转化和肿瘤的形成
- 专利标题： SCREENING ASSAY FOR ANTAGONISTS OF FGFR-MEDIATED MALIGNANT CELL TRANSFORMATION AND TUMOR FORMATION
- 专利标题（中）： 筛选分析用于拮抗剂FGFR依赖的细胞恶性转化和肿瘤的形成
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申请号： EP00901885申请日： 2000-02-03
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公开(公告)号： EP1164838A4公开(公告)日： 2002-06-19
- 发明人: YAYON AVNER , REZNITSKY DALYA , BEN-LEVY RACHEL
- 申请人： YEDA RES & DEV , PROCHON BIOTECH LTD
- 专利权人： YEDA RES & DEV,PROCHON BIOTECH LTD
- 当前专利权人： YEDA RES & DEV,PROCHON BIOTECH LTD
- 优先权： IL12838099 1999-02-04
- 主分类号： A61K49/00
- IPC分类号： A61K49/00 ; C07K14/71 ; C12P21/04 ; G01N33/50 ; A01K63/00 ; A61K48/00 ; C12N1/20 ; C12N5/00 ; C12N5/02 ; C12N15/00 ; C12N15/09 ; C12N15/63 ; C12N15/70 ; C12N15/74 ; G01N33/53 ; G01N33/567 ; G01N33/574
摘要：
In vitro and in vivo screening assays for antagonists of fibroblast growth factor receptor (FGFR)-mediated malignant cell transformation are provided using stable cell lines genetically engineered to express a recombinant wild type or constitutively active mutant FGFR selected from FGFR1, FGFR2 and FGFR3, the malignant potential of said cell lines being modulated by said FGFR.
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