专利检索 ap:("YEDA RES & DEV" OR "PROCHON BIOTECH LTD") AND inv:"REZNITSKY DALYA" 第 1 页

1.

发明公开
SCREENING ASSAY FOR ANTAGONISTS OF FGFR-MEDIATED MALIGNANT CELL TRANSFORMATION AND TUMOR FORMATION 审中-公开
标题翻译：筛选分析用于拮抗剂FGFR依赖的细胞恶性转化和肿瘤的形成

公开(公告)号：EP1164838A4

公开(公告)日：2002-06-19

申请号：EP00901885

申请日：2000-02-03

申请人： YEDA RES & DEV , PROCHON BIOTECH LTD

发明人： YAYON AVNER , REZNITSKY DALYA , BEN-LEVY RACHEL

IPC分类号： A61K49/00 , C07K14/71 , C12P21/04 , G01N33/50 , A01K63/00 , A61K48/00 , C12N1/20 , C12N5/00 , C12N5/02 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74 , G01N33/53 , G01N33/567 , G01N33/574

CPC分类号： A61K49/0004 , C07K14/71 , G01N33/5011 , G01N2333/71

摘要： In vitro and in vivo screening assays for antagonists of fibroblast growth factor receptor (FGFR)-mediated malignant cell transformation are provided using stable cell lines genetically engineered to express a recombinant wild type or constitutively active mutant FGFR selected from FGFR1, FGFR2 and FGFR3, the malignant potential of said cell lines being modulated by said FGFR.