发明公开
EP1178722A1 eNOS MUTATIONS USEFUL FOR GENE THERAPY AND THERAPEUTIC SCREENING
审中-公开
eNOS的突变基因治疗和治疗性筛选
- 专利标题： eNOS MUTATIONS USEFUL FOR GENE THERAPY AND THERAPEUTIC SCREENING
- 专利标题（中）： eNOS的突变基因治疗和治疗性筛选
-
申请号： EP00922148.2申请日： 2000-04-14
-
公开(公告)号： EP1178722A1公开(公告)日： 2002-02-13
- 发明人: SESSA, William, C.
- 申请人： YALE UNIVERSITY
- 申请人地址： 451 College Street New Haven CT 06520 US
- 专利权人： YALE UNIVERSITY
- 当前专利权人： YALE UNIVERSITY
- 当前专利权人地址： 451 College Street New Haven CT 06520 US
- 代理机构： Pfau, Anton Konrad, Dr.
- 优先权： US129550P 19990416
- 国际公布： WO0062605 20001026
- 主分类号： A01K67/00
- IPC分类号： A01K67/00 ; A01K67/033 ; A61K38/00 ; A61K31/70 ; A61K38/45 ; C07K1/00 ; C07K14/00 ; C07H21/04 ; C12Q1/00 ; C12N5/00 ; C12N5/10 ; C12N9/12 ; C12N15/00 ; C12N15/01 ; C12N15/09 ; C12N15/12 ; C12N15/52 ; C12N15/63 ; C12N15/79 ; C12N15/85
摘要：
The present invention relates to new NOS variants or mutants which contain structural alterations in the site of Akt dependent phosphorylation. The altered NOS proteins or peptides, especially the human eNOS proteins or peptides, Akt proteins or polypeptides and their encoding nucleic acid molecules are useful as gene therapy agents for the treatment of diseases including post angioplasty restenosis, hypertension, atherosclerosis, heart failure, diabetes and diseases with defective angiogenesis. NOS proteins and peptides are also useful in methods of screening for agents which modulate NOS activity.
信息查询
