发明授权
EP1204738B1 A METHOD FOR DECREASING THE FOAM FORMATION DURING CULTIVATION OF A MICROORGANISM
有权
VERFAHREN ZUR VERMINDERUNG DER SCHAUMBILDUNGWÄHRENDDER KULTIVIERUNG EINES MIKROORGANISMUS
- 专利标题： A METHOD FOR DECREASING THE FOAM FORMATION DURING CULTIVATION OF A MICROORGANISM
- 专利标题（中）： VERFAHREN ZUR VERMINDERUNG DER SCHAUMBILDUNGWÄHRENDDER KULTIVIERUNG EINES MIKROORGANISMUS
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申请号： EP00954690.4申请日： 2000-08-21
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公开(公告)号： EP1204738B1公开(公告)日： 2006-01-25
- 发明人: NAKARI-SETÄLÄ, Tiina , PENTTILÄ, Merja , BAILEY, Michael , TENKANEN, Maija
- 申请人： VALTION TEKNILLINEN TUTKIMUSKESKUS
- 申请人地址： Vuorimiehentie 5 02044 VTT FI
- 专利权人： VALTION TEKNILLINEN TUTKIMUSKESKUS
- 当前专利权人： VALTION TEKNILLINEN TUTKIMUSKESKUS
- 当前专利权人地址： Vuorimiehentie 5 02044 VTT FI
- 代理机构： Knuth-Lehtola, Sisko Hillevi
- 优先权： FI991781 19990820
- 国际公布： WO2001014521 20010301
- 主分类号： C12N1/14
- IPC分类号： C12N1/14 ; C12N15/80 ; C12N1/15
摘要：
This invention relates to a method for decreasing the foam formation during cultivation of a microorganism and to a method for producing an enhanced amount of a product of interest. The method comprises that the microorganism is modified in such a way that the microorganism does not produce an essential amount of at least one of the proteins, polypeptides or peptides associated with foam formation during cultivation of the unmodified microorganism. In particular the method comprises that the microorganism is modified not to produce an essential amount of amphipathic or hydrophobic proteins, polypeptides or peptides.
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