A METHOD FOR DECREASING THE FOAM FORMATION DURING CULTIVATION OF A MICROORGANISM
    4.
    发明授权
    A METHOD FOR DECREASING THE FOAM FORMATION DURING CULTIVATION OF A MICROORGANISM 有权
    VERFAHREN ZUR VERMINDERUNG DER SCHAUMBILDUNGWÄHRENDDER KULTIVIERUNG EINES MIKROORGANISMUS

    公开(公告)号:EP1204738B1

    公开(公告)日:2006-01-25

    申请号:EP00954690.4

    申请日:2000-08-21

    IPC分类号: C12N1/14 C12N15/80 C12N1/15

    摘要: This invention relates to a method for decreasing the foam formation during cultivation of a microorganism and to a method for producing an enhanced amount of a product of interest. The method comprises that the microorganism is modified in such a way that the microorganism does not produce an essential amount of at least one of the proteins, polypeptides or peptides associated with foam formation during cultivation of the unmodified microorganism. In particular the method comprises that the microorganism is modified not to produce an essential amount of amphipathic or hydrophobic proteins, polypeptides or peptides.

    摘要翻译: 本发明涉及一种降低微生物培养过程中泡沫形成的方法及其生产方法。 该方法包括微生物的修饰,使得微生物在培养未修饰的微生物期间不产生必需量的与泡沫形成相关的至少一种蛋白质,多肽或肽。 特别地,该方法包括修饰微生物不产生必需量的两亲或疏水性蛋白质,多肽或肽。