发明公开
EP1224182A1 1-(LACTONE)-ISOQUINOLONES N-SUBSTITUEES POUR LE TRAITEMENT DES TROUBLES NERVEUX
有权
N-取代的1-（内酯）-ISOCHINOLONE神经障碍的治疗
- 专利标题： 1-(LACTONE)-ISOQUINOLONES N-SUBSTITUEES POUR LE TRAITEMENT DES TROUBLES NERVEUX
- 专利标题（英）： N-substituted 1-(lactone) isoquinolones for treating nervous disorders
- 专利标题（中）： N-取代的1-（内酯）-ISOCHINOLONE神经障碍的治疗
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申请号： EP00969659.2申请日： 2000-10-20
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公开(公告)号： EP1224182A1公开(公告)日： 2002-07-24
- 发明人: DODD, Robert , RAZET, Rodolphe , POTIER, Pierre, Jean-Paul , SIEGHART, Werner , JURSKY, Frantisek , FURTMULLER, Roman , SIGEL, Erwin , THOMET, Urs
- 申请人： CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS) , Innovationsagentur GmbH bu Technology Marketing Austria (TECMA) , UNIVERSITE DE BERNE
- 申请人地址： 3, rue Michel Ange 75794 Paris Cedex 16 FR
- 专利权人： CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS),Innovationsagentur GmbH bu Technology Marketing Austria (TECMA),UNIVERSITE DE BERNE
- 当前专利权人： CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS),Innovationsagentur GmbH bu Technology Marketing Austria (TECMA),UNIVERSITE DE BERNE
- 当前专利权人地址： 3, rue Michel Ange 75794 Paris Cedex 16 FR
- 代理机构： Warcoin, Jacques
- 优先权： FR9913232 19991022
- 国际公布： WO0129030 20010426
- 主分类号： C07D405/04
- IPC分类号： C07D405/04 ; C07D409/04 ; C07D401/04 ; A61K31/4725 ; A61P25/00
摘要：
The invention concerns compounds of general formula (I) wherein: Z represents a sulphur or oxygen atom, NH, N-alkyl or Nboc; groups R', identical or different, represent each a hydrogen atom, a OCH3 group or a OCH2O group; group R'' represents a hydrogen or a CH3 group; group X represents a carbonyl, sulphonyl or CO2 group; and group R represents an alkyl, aryl, alkenyl or aralkyl group. The invention also concerns the preparation of said compounds, pharmaceutical compositions containing them and their use for stimulating η-amino-butyric acid activity and as medicine for treating nervous disorders.
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