发明公开
EP1263755A2 CYCLIC BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA
审中-公开
ZYKLISCHE BETA-AMINOSAUREDERIVATE ALS INHIBITOREN VON MATRIXMETALLOPROTEASEN UND TNF-ALPHA
- 专利标题： CYCLIC BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA
- 专利标题（中）： ZYKLISCHE BETA-AMINOSAUREDERIVATE ALS INHIBITOREN VON MATRIXMETALLOPROTEASEN UND TNF-ALPHA
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申请号： EP01924170.2申请日： 2001-03-15
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公开(公告)号： EP1263755A2公开(公告)日： 2002-12-11
- 发明人: DUAN, Jingwu , OTT, Gregory , CHEN, Linhua , LU, Zhonghui , MADUSKUIE, Thomas, P., Jr. , VOSS, Matthew, E. , XUE, Chu-Biao , Decicco, Carl
- 申请人： Bristol-Myers Squibb Pharma Company
- 申请人地址： PO Box 4000 Princeton,New Jesey 08543-4000 US
- 专利权人： Bristol-Myers Squibb Pharma Company
- 当前专利权人： Bristol-Myers Squibb Pharma Company
- 当前专利权人地址： PO Box 4000 Princeton,New Jesey 08543-4000 US
- 代理机构： Howard, Paul Nicholas
- 优先权： US190182P 20000317; US233373P 20000918; US255539P 20001214
- 国际公布： WO01070673 20010927
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; C07D405/12 ; C07D307/24 ; C07D215/14 ; A61K31/55
摘要：
The present application describes novel cyclic β-amino acid derivatives of formula (I) or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms selected from O, N, NRa, and S(O)¿p?, and 0-1 carbonyl groups and the other variables are defined in the present specification, which are useful as metalloprotease and as TNF-α inhibitors.
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