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1.发明授权
公开(公告)号：EP1337251B1
公开(公告)日：2008-08-20
申请号：EP01274110.4
申请日：2001-10-30
发明人： JACOBSON, Irina, C. , WEXLER, Ruth, R. , QIAO, Jennifer , NAKAJIMA, Suanne , QUAN, Mimi, L. , WANG, Shuaige , SMALLHEER, Joanne, M.
IPC分类号： A61K31/445 , A61K31/495 , A61K31/4704 , C07D211/76 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/12 , C07D241/08 , C07D215/22 , C07D223/12 , A61P7/02
CPC分类号： C07D239/10 , C07D211/76 , C07D223/10 , C07D241/08 , C07D243/08 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： The present application describes monocyclic or bicyclic carbocycles and heterocycles and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
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2.发明公开SUBSTITUTED HETEROARYL AMIDE MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NFkB ACTIVITY AND USE THEREOF 有权取代HETEROARYLAMIDMODULATOREN糖皮质激素受体的活性，AP-1和/或这样的NFκB的使用与
公开(公告)号：EP1896434A1
公开(公告)日：2008-03-12
申请号：EP06718407.7
申请日：2006-01-13
发明人： SHEPPECK, James E. , DHAR, T. G. Murali , DOWEYKO, Arthur M. P. , DOWEYKO, Lidia M. , GILMORE, John L. , WEINSTEIN, David S. , XIAO, Hai-Yun , YANG, Bingwei Vera
IPC分类号： C07D277/46
CPC分类号： C07D233/91 , C07D277/46 , C07D417/06
摘要： The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NFκB activity including obesity, diabetes, inflammatory- and immune-associated diseases, and have the structure (I) including all stereoisomers thereof, tautomers thereof, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, wherein X is selected from N, O, and S; Y is N or CR6; Z is a ring; and where R, Ra, Rb, Rc, Rd, R1, R2, R3, R4, and R5 are as defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.
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公开(公告)号：EP1195168A3
公开(公告)日：2007-05-30
申请号：EP01123928.2
申请日：1996-04-03
发明人： Edwards, David S. , Liu, Shuang
IPC分类号： A61K51/08 , A61M36/14 , C07F5/00 , C07F13/00 , A61K103/10
CPC分类号： C07K14/75 , A61K51/0476 , A61K51/0497 , A61K51/082 , A61K51/088 , A61K2123/00 , C07B59/004 , C07B59/008 , C07K7/56
摘要： This invention provides novel radiopharmaceuticals which are useful as imaging agents for the diagnosis of cardiovascular disorders, infectious diseases and cancer. The radiopharmaceuticals are comprised of phosphine or arsine ligated technetium-99m labelled hydrazine or diazino modified biologically active molecules that selectively localize at sites of disease and thus allow an image to be obtained of the loci using gamma scintigraphy. This invention also provides methods for using the radiopharmaceuticals and kits comprising radiopharmaceutical precursors. The radiopharmaceuticals of this invention havee the structure: [(Q) d' L n -C h' ] x -M t (A L1 ) y (A L2 ) z wherein the variables are as defined therein.
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4.发明授权4-(2-BUTYLAMINO)-2,7-DIMETHYL-8-(2-METHYL-6-METHOXYPYRID-3-YL) PYRAZOLO- 1,5-A|-1,3,5-TRIAZINE, ITS ENANTIOMERS AND PHARMACEUTICALLY ACCEPTABLE SALTS AS CORTICOTROPIN RELEASING FACTOR RECEPTOR LIGANDS 有权4-（2-丁基氨基）-2,7-二甲基-8-（2-甲基-6-甲氧基吡啶-3-基）吡唑并1,5-A -1,3,5-三嗪，其对映体和药学上可接受的 AS促肾上腺皮质激素的盐类释放因子受体配体
公开(公告)号：EP1368094B1
公开(公告)日：2007-02-28
申请号：EP02713776.9
申请日：2002-03-06
发明人： GILLIGAN, Paul, J.
IPC分类号： A61P25/00 , A61P25/24 , A61K31/53 , C07D403/00
CPC分类号： A61K31/53 , C07D487/04
摘要： Corticotropin releasing factor (CRF) antagonists of Formula (I), and its use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.
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公开(公告)号：EP0944619B1
公开(公告)日：2006-10-11
申请号：EP97950692.0
申请日：1997-11-26
IPC分类号： C07D401/12 , A61K31/395 , C07D215/56 , C07D413/14
CPC分类号： C07D401/12 , C07D215/56 , C07D413/14
摘要： This invention relates to novel fused heterocycles which are useful as antagonists of the αvβ3 and related integrin receptors of Formula (I), to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion, the treatment of angiogenic disorders, inflammation, bone degradation, cancer metastasis, diabetic retinopathy, thrombosis, restenosis, macular degeneration, and other conditions mediated by cell adhesion and/or cell migration and/or angiogenesis.
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公开(公告)号：EP1689493A1
公开(公告)日：2006-08-16
申请号：EP03819270.4
申请日：2003-12-05
发明人： DEGNAN, Andrew, P. , CHEN, Ling , CIVIELLO, Rita , DUBOWCHIK, Gene, M. , HAN, Xiaojun , JIANG, Xiang, Jun, J. , MACOR, John, E. , TORA, George , LUO, Guanglin
IPC分类号： A61P25/06 , A61K31/535 , A61K31/52 , A61K31/55 , A61K31/54 , A61K31/495 , A61K31/50 , C07D239/00 , C07D243/10 , C07D265/00 , C07D285/00
CPC分类号： C07D471/04 , C07D209/08 , C07D231/56 , C07D249/18 , C07D401/06 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/10 , C07D491/10
摘要： The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors ('CGRP-receptor'), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
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7.发明公开METHODS FOR TREATING CARDIOVASCULAR DISEASE USING A SOLUBLE CTLA4 MOLECULE 审中-公开方法用于治疗心血管疾病与可溶性CTLA4分子治疗
公开(公告)号：EP1670499A2
公开(公告)日：2006-06-21
申请号：EP04779791.5
申请日：2004-08-03
发明人： RUSNAK, James
IPC分类号： A61K38/17 , A61K39/395
CPC分类号： C07K16/2818 , A61K38/00 , C07K14/70521 , C07K2319/30
摘要： The present invention relates to compositions and methods for treating cardiovascular system diseases by administering to a subject soluble CTLA4 molecules that block endogenous B7 molecules from binding their ligands.
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8.发明授权METHOD AND APPARATUS FOR SEPARATING IONS OF METALLIC ELEMENTS IN AQUEOUS SOLUTION 有权方法和装置离子的金属元素在水溶液中分离
公开(公告)号：EP1481402B1
公开(公告)日：2006-03-08
申请号：EP02805174.6
申请日：2002-12-18
IPC分类号： G21G4/08
CPC分类号： G21G1/0005 , G21G2001/0078 , G21G2001/0094
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9.发明授权
公开(公告)号：EP1307431B1
公开(公告)日：2005-10-26
申请号：EP01959231.0
申请日：2001-07-26
发明人： ZHOU, Jia, Cheng , CONFALONE, Pasquale, N. , LI, Hui-Yin , OH, Lynette, M. , ROSSANO, Lucius, T. , CLARK, Charles, G. , TELEHA, Christopher, A. , MA, Philip
IPC分类号： C07D233/54 , C07D233/66
CPC分类号： C07D233/54 , C07D231/12 , C07D233/38 , C07D233/56 , C07D233/64 , C07D249/08
摘要： The present invention provides of method of preparing phenyl-substituted azoles. This method uses an efficient ligand-accelerated Ullmann coupling reaction of anilines with azoles. The coupling products are useful for preparing factor Xa inhibitors.
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公开(公告)号：EP1068224B1
公开(公告)日：2005-05-11
申请号：EP99941944.3
申请日：1999-03-29
发明人： RAJOPADHYE, Miland , EDWARDS, D., Scott , HARRIS, Thomas, D. , HEMINWAY, Stuart, J. , LIU, Shuang , SINGH, Prahlad, R.
CPC分类号： A61K49/0002 , A61K49/227 , A61K51/082 , A61K51/088 , C07D401/12 , C07D401/14
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