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1.发明公开BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA 有权作为基质金属蛋白酶和TNF-α抑制剂的β氨基酸衍生物
公开(公告)号：EP1263756A2
公开(公告)日：2002-12-11
申请号：EP01924171.0
申请日：2001-03-15
发明人： DUAN, Jingwu , KING, Bryan, W. , DECICCO, Carl , MADUSKUIE, Thomas, P., Jr. , VOSS, Matthew, E.
IPC分类号： C07D401/12 , C07D211/34 , C07D215/14 , C07D417/12 , C07D405/12 , C07D401/06 , C07D401/14 , C07D211/58 , C07D409/12 , C07D405/14 , A61K31/4545 , A61P29/00
CPC分类号： C07D401/06 , C07D211/34 , C07D211/58 , C07D215/14 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12
摘要： The present application describes novel β-amino acid derivatives of formula (I) or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, X, Z, U?a, Xa, Ya, Za, R1, R2, R3, R4, and R4a¿ are defined in the present specification, which are useful as metalloprotease and as TNF-α inhibitors.
摘要翻译： 本申请描述了式（I）的新型β-氨基酸衍生物或其药学上可接受的盐或前药形式，其中A，X，Z，Uαa，Xa，Ya，Za，R1，R2，R3，R4和 R4a在本说明书中定义，其可用作金属蛋白酶和TNF-α抑制剂。
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2.发明公开CYCLIC BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA 审中-公开ZYKLISCHE BETA-AMINOSAUREDERIVATE ALS INHIBITOREN VON MATRIXMETALLOPROTEASEN UND TNF-ALPHA
公开(公告)号：EP1263755A2
公开(公告)日：2002-12-11
申请号：EP01924170.2
申请日：2001-03-15
发明人： DUAN, Jingwu , OTT, Gregory , CHEN, Linhua , LU, Zhonghui , MADUSKUIE, Thomas, P., Jr. , VOSS, Matthew, E. , XUE, Chu-Biao , Decicco, Carl
IPC分类号： C07D401/12 , C07D405/12 , C07D307/24 , C07D215/14 , A61K31/55
CPC分类号： C07D417/14 , C07C259/08 , C07C2601/08 , C07D213/56 , C07D213/82 , C07D215/12 , C07D215/14 , C07D261/02 , C07D307/24 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D417/12
摘要： The present application describes novel cyclic β-amino acid derivatives of formula (I) or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms selected from O, N, NRa, and S(O)¿p?, and 0-1 carbonyl groups and the other variables are defined in the present specification, which are useful as metalloprotease and as TNF-α inhibitors.
摘要翻译： 本申请描述了式I的新的环状β-氨基酸衍生物或其药学上可接受的盐形式，其中环B是含有0-2个选自O，N，NR a的杂原子的5-7元环系 和/或S（O）P和O-1羰基，其它变量在本说明书中定义，其可用作金属蛋白酶和/或作为TNF-α抑制剂。
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公开(公告)号：EP1299379A2
公开(公告)日：2003-04-09
申请号：EP01951042.9
申请日：2001-07-11
IPC分类号： C07D401/12 , C07D405/14 , C07D207/26 , C07D401/06 , C07D405/06 , C07D409/06 , A61K31/4015 , A61P29/00
CPC分类号： C07D207/27 , C07D207/273 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/14 , C07D409/06
摘要： The present application describes novel lactams and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 4-8 membered cyclic amide comprising 0-3 additional heteroatoms selected from N, O, and S, which are useful as metalloprotease inhibitors.
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公开(公告)号：EP1027332B1
公开(公告)日：2004-05-26
申请号：EP98950954.2
申请日：1998-10-02
IPC分类号： C07D207/27 , A61K31/40 , C07D401/12 , C07D417/12
CPC分类号： C07D207/26 , C07D205/08 , C07D209/96 , C07D211/76 , C07D233/32 , C07D233/78 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/10
摘要： The present application describes novel lactams and derivatives thereof of formula (I), or pharmaceutically acceptable salt forms thereof, wherein ring B is a 4-8 membered cyclic amide containing from 0-3 additional heteroatoms selected from N, O, and S, which are useful as metalloprotease inhibitors.
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5.发明授权BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA 有权BETA阿明酸衍生物FOR USE AS MATRIX METALLOPROTEASEN-和TNA ALPHA抑制剂
公开(公告)号：EP1263756B1
公开(公告)日：2004-02-25
申请号：EP01924171.0
申请日：2001-03-15
发明人： DUAN, Jingwu , KING, Bryan, W. , DECICCO, Carl , MADUSKUIE, Thomas, P., Jr. , VOSS, Matthew, E.
IPC分类号： C07D401/12 , C07D211/34 , C07D215/14 , C07D417/12 , C07D405/12 , C07D401/06 , C07D401/14 , C07D211/58 , C07D409/12 , C07D405/14 , A61K31/4545 , A61P29/00
CPC分类号： C07D401/06 , C07D211/34 , C07D211/58 , C07D215/14 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12
摘要： The present application describes novel β-amino acid derivatives of formula (I) or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, X, Z, U?a, Xa, Ya, Za, R1, R2, R3, R4, and R4a¿ are defined in the present specification, which are useful as metalloprotease and as TNF-α inhibitors.
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