发明授权
EP1272500B1 PROCESS FOR PREPARING 6-O-ALKENYL-SUBSITUTED ERYTHROMYCIN DERIVATIVES
有权
用于生产6-O-烯基SUBSITUTIERTEN红霉素衍生物
- 专利标题： PROCESS FOR PREPARING 6-O-ALKENYL-SUBSITUTED ERYTHROMYCIN DERIVATIVES
- 专利标题（中）： 用于生产6-O-烯基SUBSITUTIERTEN红霉素衍生物
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申请号： EP00942860.8申请日： 2000-06-15
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公开(公告)号： EP1272500B1公开(公告)日： 2005-05-04
- 发明人: STONER, Eric J. , PETERSON, Matthew J. , KU, Yi-Yin , CINK, Russell D. , COOPER, Arthur J. , DESHPANDE, Mahendra N. , GRIEME, Tim , HAIGHT, Anthony R. , HILL, David R. , HSU, Margaret, Chi-Ping , KING, Steven A. , LEANNA, Marvin R. , LEE, Elaine C. , MCLAUGHLIN, Maureen A. , MORTON, Howard E. , NAPIER, James J. , PLATA, Daniel J. , RAJE, Prasad S. , RASMUSSEN, Michael , RILEY, David , TIEN, Jien-Heh J. , WITTENBERGER, Steven J.
- 申请人： Abbott Laboratories
- 申请人地址： D377/AP6D 100 Abbott Park Road Abbott Park, IL 60064-6050 US
- 专利权人： Abbott Laboratories
- 当前专利权人： Abbott Laboratories
- 当前专利权人地址： D377/AP6D 100 Abbott Park Road Abbott Park, IL 60064-6050 US
- 代理机构： Modiano, Guido, Dr.-Ing.
- 优先权： US140968P 19990624
- 国际公布： WO2000078773 20001228
- 主分类号： C07H17/08
- IPC分类号： C07H17/08 ; A61K31/70 ; A61P31/04
摘要：
In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4'-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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