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1.发明公开PROCESS FOR PREPARING 6-O-ALKENYL-SUBSITUTED ERYTHROMYCIN DERIVATIVES 有权用于生产6-O-烯基SUBSITUTIERTEN红霉素衍生物
公开(公告)号：EP1272500A2
公开(公告)日：2003-01-08
申请号：EP00942860.8
申请日：2000-06-15
申请人： Abbott Laboratories
发明人： STONER, Eric J. , PETERSON, Matthew J. , KU, Yi-Yin , CINK, Russell D. , COOPER, Arthur J. , DESHPANDE, Mahendra N. , GRIEME, Tim , HAIGHT, Anthony R. , HILL, David R. , HSU, Margaret, Chi-Ping , KING, Steven A. , LEANNA, Marvin R. , LEE, Elaine C. , MCLAUGHLIN, Maureen A. , MORTON, Howard E. , NAPIER, James J. , PLATA, Daniel J. , RAJE, Prasad S. , RASMUSSEN, Michael , RILEY, David , TIEN, Jien-Heh J. , WITTENBERGER, Steven J.
CPC分类号： C07H17/08
摘要： In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4'-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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2.发明授权PROCESS FOR PREPARING 6-O-ALKENYL-SUBSITUTED ERYTHROMYCIN DERIVATIVES 有权用于生产6-O-烯基SUBSITUTIERTEN红霉素衍生物
公开(公告)号：EP1272500B1
公开(公告)日：2005-05-04
申请号：EP00942860.8
申请日：2000-06-15
申请人： Abbott Laboratories
发明人： STONER, Eric J. , PETERSON, Matthew J. , KU, Yi-Yin , CINK, Russell D. , COOPER, Arthur J. , DESHPANDE, Mahendra N. , GRIEME, Tim , HAIGHT, Anthony R. , HILL, David R. , HSU, Margaret, Chi-Ping , KING, Steven A. , LEANNA, Marvin R. , LEE, Elaine C. , MCLAUGHLIN, Maureen A. , MORTON, Howard E. , NAPIER, James J. , PLATA, Daniel J. , RAJE, Prasad S. , RASMUSSEN, Michael , RILEY, David , TIEN, Jien-Heh J. , WITTENBERGER, Steven J.
CPC分类号： C07H17/08
摘要： In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2'-substituted and optionally 4'-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
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