发明公开
EP1274724A2 MACROCYCLIC NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS COMPRISING ALKYL AND ARYL ALANINE P2 MOIETIES
审中-公开
丙型肝炎病毒与烷基和芳基丙氨酸GROUPS IN POSITION P2大环NS3丝氨酸蛋白酶抑制剂
- 专利标题： MACROCYCLIC NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS COMPRISING ALKYL AND ARYL ALANINE P2 MOIETIES
- 专利标题（中）： 丙型肝炎病毒与烷基和芳基丙氨酸GROUPS IN POSITION P2大环NS3丝氨酸蛋白酶抑制剂
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申请号： EP01927142.8申请日： 2001-04-17
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公开(公告)号： EP1274724A2公开(公告)日： 2003-01-15
- 发明人: VENKATRAMAN, Srikanth , CHEN, Kevin, X. , ARASAPPAN, Ashok , NJOROGE, F., George , GIRIJAVALLABHAN, Viyyoor, M. , CHAN, Tin-Yau , MCKITTRICK, Brian, A. , PRONGAY, Andrew, J. , MADISON, Vincent, S.
- 申请人： SCHERING CORPORATION
- 申请人地址： 2000 Galloping Hill Road Kenilworth,New Jersey 07033-0530 US
- 专利权人： SCHERING CORPORATION
- 当前专利权人： SCHERING CORPORATION
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth,New Jersey 07033-0530 US
- 代理机构： Ritter, Stephen David
- 优先权： US198204P 20000419
- 国际公布： WO01081325 20011101
- 主分类号： C07K7/06
- IPC分类号： C07K7/06 ; C07K14/18 ; C07K5/062 ; C07K5/065 ; C07K5/107 ; A61K38/05 ; A61K38/07 ; A61K38/08 ; A61P31/14
摘要：
The present invention discloses novel macrocyclic compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such macrocycles as well as methods of using them to treat disorders associated with the HCV protease.
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