公开(公告)号：EP2139854A2

公开(公告)日：2010-01-06

申请号：EP08826269.6

申请日：2008-03-20

申请人： Schering Corporation

发明人： VENKATRAMAN, Srikanth ,  NJOROGE, F., George ,  VELAZQUEZ, Francisco ,  WU, Wanli ,  MADISON, Vincent, S. ,  SHIH, Neng-Yang

IPC分类号： C07D207/16 ,  C07D401/12 ,  A61K31/401 ,  A61P31/12

CPC分类号： C07D207/16 ,  C07D401/12

摘要： The present invention discloses novel compounds, which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

公开(公告)号：EP1467989A1

公开(公告)日：2004-10-20

申请号：EP03705843.5

申请日：2003-01-21

申请人： SCHERING CORPORATION

发明人： ARASAPPAN, Ashok ,  BENNETT, Frank ,  BOGEN, Stephane, L. ,  CHEN, Kevin, X. ,  JAO, Edwin ,  LIU, Yi-Tsung ,  LOVEY, Raymond, G. ,  MADISON, Vincent, S. ,  NAIR, Latha, G. ,  NJOROGE, F., George ,  SAKSENA, Anil, K. ,  SANNIGRAHI, Mousumi ,  VENKATRAMAN, Srikanth ,  GIRIJAVALLABHAN, Viyyoor, M.

IPC分类号： C07D403/12 ,  A61K38/55 ,  A61P31/12

CPC分类号： C07D207/27 ,  C07D207/16 ,  C07D209/08 ,  C07D209/42 ,  C07D211/26 ,  C07D211/34 ,  C07D211/70 ,  C07D213/75 ,  C07D217/26 ,  C07D233/68 ,  C07D243/12 ,  C07D253/06 ,  C07D271/06 ,  C07D277/06 ,  C07D277/46 ,  C07D277/56 ,  C07D295/15 ,  C07D307/68 ,  C07D317/58 ,  C07D335/10 ,  C07D401/04 ,  C07D401/14 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12

摘要： The present invention discloses novel compounds of Formula I which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

公开(公告)号：EP1467989B1

公开(公告)日：2009-09-23

申请号：EP03705843.5

申请日：2003-01-21

申请人： Schering Corporation

发明人： ARASAPPAN, Ashok ,  BENNETT, Frank ,  BOGEN, Stephane, L. ,  CHEN, Kevin, X. ,  JAO, Edwin ,  LIU, Yi-Tsung ,  LOVEY, Raymond, G. ,  MADISON, Vincent, S. ,  NAIR, Latha, G. ,  NJOROGE, F., George ,  SAKSENA, Anil, K. ,  SANNIGRAHI, Mousumi ,  VENKATRAMAN, Srikanth ,  GIRIJAVALLABHAN, Viyyoor, M.

IPC分类号： C07D403/12 ,  A61K38/55 ,  A61P31/12

CPC分类号： C07D207/27 ,  C07D207/16 ,  C07D209/08 ,  C07D209/42 ,  C07D211/26 ,  C07D211/34 ,  C07D211/70 ,  C07D213/75 ,  C07D217/26 ,  C07D233/68 ,  C07D243/12 ,  C07D253/06 ,  C07D271/06 ,  C07D277/06 ,  C07D277/46 ,  C07D277/56 ,  C07D295/15 ,  C07D307/68 ,  C07D317/58 ,  C07D335/10 ,  C07D401/04 ,  C07D401/14 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12

摘要： The present invention discloses novel compounds of Formula I which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

公开(公告)号：EP1966151A1

公开(公告)日：2008-09-10

申请号：EP06845064.2

申请日：2006-12-11

申请人： Schering Corporation

发明人： COOPER, Alan ,  DENG, Yongqi ,  SHIPPS, Gerald, W., Jr. ,  SHIH, Neng-yang ,  ZHU, Hugh ,  SUN, Robert ,  KELLY, Joseph ,  DOLL, Ronald ,  NAN, Yang ,  WANG, Tong ,  DESAI, Jagdish ,  WANG, James ,  DONG, Youhao ,  MADISON, Vincent, S. ,  XIAO, Li ,  HRUZA, Alan ,  SIDDIQUI, M., Arshad ,  SAMATAR, Ahmed ,  PALIWAL, Sunil ,  TSUI, Hon-Chung ,  CELEBI, Azim, A. ,  WU, Yiji ,  BOGA, Sobhana, Babu

IPC分类号： C07D231/56 ,  C07D403/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  A61K31/506 ,  A61K31/427 ,  A61K31/428 ,  A61K31/496 ,  A61P35/00 ,  C07D417/14 ,  C07D403/14

CPC分类号： C07D405/14 ,  C07D231/56 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/14

摘要： Disclosed are the ERK inhibitors of formula 1.0 and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.

公开(公告)号：EP1778676B1

公开(公告)日：2010-08-25

申请号：EP05771446.1

申请日：2005-07-13

申请人： Schering Corporation

发明人： YU, Wensheng ,  TONG, Ling ,  CHEN, Lei ,  KOZLOWSKI, Joseph, A. ,  LAVEY, Brian, J. ,  SHIH, Neng-Yang ,  MADISON, Vincent, S. ,  ZHOU, Guowei ,  ORTH, Peter ,  GUO, Zhuyan ,  WONG, Michael, K. C. ,  YANG, De-Yi ,  KIM, Seong, Heon ,  SHANKAR, Bandarpalle

IPC分类号： C07D403/06 ,  C07D417/14 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  A61P43/00 ,  A61P29/00 ,  A61K31/4178

CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

摘要： This invention relates to compounds of Formula (1) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF- or combinations thereof.

公开(公告)号：EP1268525B1

公开(公告)日：2008-12-31

申请号：EP01926601.4

申请日：2001-04-03

申请人： Schering Corporation

发明人： CHEN, Kevin, X. ,  ARASAPPAN, Ashok ,  VENKATRAMAN, Srikanth ,  PAREKH, Tejal, N. ,  GU, Haining ,  NJOROGE, F., George ,  GIRIJAVALLABHAN, Viyyoor, M. ,  GANGULY, Ashit ,  SAKSENA, Anil ,  JAO, Edwin ,  YAO, Nanhua, H. ,  PRONGAY, Andrew, J. ,  MADISON, Vincent, S. ,  VIBULBHAN, Bancha

IPC分类号： C07K7/06 ,  C07K14/18 ,  C07K5/062 ,  C07K5/065 ,  C07K5/087 ,  C07K5/107 ,  A61K38/05 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61P31/14

CPC分类号： C07K5/12 ,  A61K38/00 ,  C07K1/02 ,  C07K5/08 ,  C07K5/0802 ,  C07K5/0806 ,  C07K7/02

摘要： The present invention discloses novel macrocyclic compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such macrocycles as well as methods of using them to treat disorders associated with the HCV protease.

公开(公告)号：EP1984331B1

公开(公告)日：2010-10-20

申请号：EP07750497.5

申请日：2007-02-13

申请人： Schering Corporation

发明人： DENG, Yongqi ,  SHIPPS, Gerald, W., Jr. ,  COOPER, Alan ,  NAN, Yang ,  WANG, Tong ,  SIDDIQUI, M., Arshad ,  ZHU, Hugh ,  SUN, Robert ,  KELLY, Joseph ,  DOLL, Ronald ,  DESAI, Jagdish ,  WANG, James ,  DONG, Youhao ,  MADISON, Vincent, S. ,  XIAO, Li ,  HRUZA, Alan ,  SHIH, Neng-yang

IPC分类号： C07D207/16 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D487/08 ,  A61K31/4025 ,  A61P35/00

CPC分类号： C07D207/16 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/08

摘要： Disclosed are the ERK inhibitors of Formula (1.0): and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of Formula (1.0).

公开(公告)号：EP1976849A2

公开(公告)日：2008-10-08

申请号：EP07709799.6

申请日：2007-01-16

申请人： Schering Corporation

发明人： YU, Wensheng ,  TONG, Ling ,  CHEN, Lei ,  KOZLOWSKI, Joseph, A. ,  LAVEY, Brian, J. ,  SHIH, Neng-Yang ,  MADISON, Vincent, S. ,  ZHOU, Guowei ,  ORTH, Peter ,  GUO, Zhuyan ,  WONG, Michael, K.C. ,  YANG, De-Yi ,  KIM, Seong-Heon ,  SHANKAR, Bandarpalle, B. ,  SIDDIQUI, M., Arshad ,  ROSNER, Kristin, E. ,  DAI, Chaoyang ,  POPOVICI-MULLER, Janeta ,  GIRIJAVALLABHAN, Vinay, M. ,  LI, Dansu ,  RIZVI, Razia ,  MICULA, Aneta, S ,  FELTZ, Robert

IPC分类号： C07D401/14 ,  C07D403/06 ,  A61P35/00 ,  A61K31/4166 ,  C07D471/04 ,  C07D473/34 ,  C07D473/00 ,  C07D491/04 ,  C07D495/04 ,  C07D417/14 ,  C07D413/14 ,  C07D405/14 ,  C07D403/14

CPC分类号： C07D403/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D473/34 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

摘要： This invention relates to compounds of the Formula (I) or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

摘要翻译： 本发明涉及可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖酶，TNF-或其组合介导的疾病或病症的式（I）化合物或其药学上可接受的盐，溶剂化物，酯或异构体 。

公开(公告)号：EP1957058A1

公开(公告)日：2008-08-20

申请号：EP06844652.5

申请日：2006-11-29

申请人： Schering Corporation

发明人： SIDDIQUI, M., Arshad ,  MANSOOR, Umar, Faruk ,  REDDY, Panduranga, A. ,  MADISON, Vincent, S.

IPC分类号： A61K31/16 ,  C07D207/06 ,  C07D207/08 ,  C07D207/09 ,  C07D207/14 ,  C07D209/08 ,  C07D209/44 ,  C07D211/10 ,  C07D211/18 ,  C07D211/32 ,  C07D211/46 ,  C07D211/54 ,  C07D211/58 ,  C07D211/62 ,  C07D211/64

CPC分类号： C07D207/06 ,  C07C235/06 ,  C07C235/08 ,  C07C235/10 ,  C07C235/14 ,  C07C235/16 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2602/08 ,  C07D207/08 ,  C07D207/09 ,  C07D207/14 ,  C07D207/20 ,  C07D207/26 ,  C07D209/08 ,  C07D209/44 ,  C07D211/10 ,  C07D211/18 ,  C07D211/32 ,  C07D211/46 ,  C07D211/54 ,  C07D211/58 ,  C07D211/62 ,  C07D211/64 ,  C07D213/40 ,  C07D213/74 ,  C07D215/14 ,  C07D217/06 ,  C07D231/12 ,  C07D233/26 ,  C07D239/26 ,  C07D243/08 ,  C07D263/32 ,  C07D295/135 ,  C07D295/185 ,  C07D307/52 ,  C07D307/68 ,  C07D333/20 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D513/04

摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, aggrecanase, ADMP, LpxC, ADAMs, TACE, TNF-α or combinations thereof.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂化物或异构体，其可用于治疗由MMPs，aggrecanase，ADMP，LpxC，ADAMs，TACE，TNF- α或其组合。

公开(公告)号：EP1778676A1

公开(公告)日：2007-05-02

申请号：EP05771446.1

申请日：2005-07-13

申请人： SCHERING CORPORATION

发明人： YU, Wensheng ,  TONG, Ling ,  CHEN, Lei ,  KOZLOWSKI, Joseph, A. ,  LAVEY, Brian, J. ,  SHIH, Neng-Yang ,  MADISON, Vincent, S. ,  ZHOU, Gouwei ,  ORTH, Peter ,  GUO, Zhuyan ,  WONG, Michael, K. C. ,  YANG, De-Yi ,  KIM, Seong, Heon ,  SHANKAR, Bandarpalle

IPC分类号： C07D403/06 ,  C07D417/14 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  A61P43/00 ,  A61P29/00 ,  A61K31/4178

CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

摘要： This invention relates to compounds of Formula (1) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF- or combinations thereof.