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1.发明公开ANTIVIRAL COMPOUNDS COMPOSED OF THREE LINKED ARYL MOIETIES TO TREAT DISEASES SUCH AS HEPATITIS C 有权THREE彼此相关芳基单元组合抗病毒化合物FOR疾病，如肝炎C的治疗
公开(公告)号：EP2435424A1
公开(公告)日：2012-04-04
申请号：EP10721906.5
申请日：2010-05-28
申请人： Schering Corporation
发明人： ZENG, Qingbei , CHEN, Kevin, X. , ANILKUMAR, Gopinadhan, N. , ROSENBLUM, Stuart, B. , KOZLOWSKI, Joseph, A. , NJOROGE, F., George
IPC分类号： C07D403/14 , A61P31/12 , A61K31/4184
CPC分类号： C07D403/14
摘要： The present invention relates to novel Linked Tricyclic Aryl Compounds, compositions comprising at least one Linked Tricyclic Compound, and methods of using Linked Tricyclic Aryl Compounds for treating or preventing HCV infection in a patient. in one aspect, the present invention provides Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein: Non-limiting examples of the Compounds of Formula (II) include compound 56
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2.发明授权MACROCYCLIC NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS COMPRISING N-CYCLIC P2 MOIETIES 有权与含氮CYCLIC P2 GROUPS丙型肝炎病毒的大环NS3丝氨酸蛋白酶抑制剂
公开(公告)号：EP1268525B1
公开(公告)日：2008-12-31
申请号：EP01926601.4
申请日：2001-04-03
申请人： Schering Corporation
发明人： CHEN, Kevin, X. , ARASAPPAN, Ashok , VENKATRAMAN, Srikanth , PAREKH, Tejal, N. , GU, Haining , NJOROGE, F., George , GIRIJAVALLABHAN, Viyyoor, M. , GANGULY, Ashit , SAKSENA, Anil , JAO, Edwin , YAO, Nanhua, H. , PRONGAY, Andrew, J. , MADISON, Vincent, S. , VIBULBHAN, Bancha
IPC分类号： C07K7/06 , C07K14/18 , C07K5/062 , C07K5/065 , C07K5/087 , C07K5/107 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , A61P31/14
CPC分类号： C07K5/12 , A61K38/00 , C07K1/02 , C07K5/08 , C07K5/0802 , C07K5/0806 , C07K7/02
摘要： The present invention discloses novel macrocyclic compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such macrocycles as well as methods of using them to treat disorders associated with the HCV protease.
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公开(公告)号：EP1730165A1
公开(公告)日：2006-12-13
申请号：EP05724112.7
申请日：2005-02-24
申请人： SCHERING CORPORATION
发明人： BOGEN, Stephane, L. , PAN, Weidong , RUAN, Sumei , CHEN, Kevin, X. , ARASAPPAN, Ashok , VENKATRAMAN, Srikanth , NAIR, Latha, G. , SANNIGRAHI, Mousumi , BENNETT, Frank , SAKSENA, Anil, K. , NJOROGE, F., George , GIRIJAVALLABHAN, Viyyoor, M.
IPC分类号： C07K5/02 , C07D209/52 , C07D417/12 , C07D401/12 , C07D409/12 , C07D403/12 , C07D407/12 , C07D413/12 , C07D491/04 , C07D209/70 , C07D495/10 , C07D207/10 , C07D295/16 , A61K31/403 , A61K31/427
CPC分类号： C07D209/52 , A61K38/00 , C07D209/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/0205 , C07K5/0808 , C07K5/0812 , C07K5/0827
摘要： The present invention discloses novel compounds of formula (I) which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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4.发明公开NOVEL KETOAMIDES WITH CYCLIC P4'S AS INHIBITORS OF NS3 SERINE PROTEASE OF HEPATITIS C VIRUS 有权与来自丙型肝炎病毒NS3丝氨酸蛋白酶的抗循环P4作为抑制剂NEW酮酰胺
公开(公告)号：EP1730142A1
公开(公告)日：2006-12-13
申请号：EP05723688.7
申请日：2005-02-24
申请人： SCHERING CORPORATION
发明人： CHEN, Kevin, X. , NJOROGE, F., George , SANNIGRAHI, Mousumi , NAIR, Latha, G. , YANG, Weiying , VIBULBHAN, Bancha , VENKATRAMAN, Srikanth , ARASAPPAN, Ashok , BOGEN, Stephane, L. , BENNETT, Frank , GIRIJAVALLABHAN, Viyyoor, M.
IPC分类号： C07D417/12 , C07D513/04 , C07D401/12 , C07D209/52 , C07K5/08 , A61K31/40 , A61P31/12
CPC分类号： C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/0205 , C12Q1/707
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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5.发明公开
公开(公告)号：EP2430015A1
公开(公告)日：2012-03-21
申请号：EP10720692.2
申请日：2010-05-12
申请人： Schering Corporation
发明人： ROSENBLUM, Stuart, B. , CHEN, Kevin, X. , KOZLOWSKI, Joseph, A. , NJOROGE, F., George , COBURN, Craig, A.
IPC分类号： C07D403/04 , C07D403/14 , C07D471/04 , C07D487/04 , C07D491/044 , C07D493/04 , A61P31/12 , A61K31/4178 , A61K31/437 , A61K31/55
CPC分类号： C07D403/14 , C07C403/04 , C07D403/04 , C07D471/04 , C07D487/04 , C07D491/044 , C07D493/04
摘要： The present invention relates to novel Fused Tricyclic Aryl Compounds, compositions comprising at least one Fused Tricyclic Aryl Compound, and methods of using the Fused Tricyclic Aryl Compounds for treating or preventing HCV infection in a patient.
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公开(公告)号：EP2408761A1
公开(公告)日：2012-01-25
申请号：EP08795629.8
申请日：2008-08-27
申请人： Schering Corporation
发明人： ANILKUMAR, Gopinadhan, N. , BENNETT, Frank , CHAN, Tin-Yau , CHEN, Kevin, X. , SANNIGRAHI, Mousumi , VELAZQUEZ, Francisco , VENKATRAMAN, Srikanth , ZENG, Qingbei , DUCA, Jose, S. , LESBURG, Charles, A. , KOZLOWSKI, Joseph, A. , NJOROGE, F., George , ROSENBLUM, Stuart, B. , SHIH, Neng-Yang
IPC分类号： C07D401/04 , C07D403/04 , A61K31/513 , A61P31/12
CPC分类号： C07D403/04 , C07D401/04
摘要： The present invention relates to Substituted Indole Derivatives, compositions comprising at least one Substituted Indole Derivative, and methods of using these Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
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7.发明公开TETRACYCLIC INDOLE DERIVATIVES AND THEIR USE FOR TREATING OR PREVENTING VIRAL INFECTIONS 审中-公开四环吲哚衍生物，以及它们用于病毒感染的治疗或预防
公开(公告)号：EP2197884A2
公开(公告)日：2010-06-23
申请号：EP08795628.0
申请日：2008-08-27
申请人： Schering Corporation
发明人： BENNETT, Frank , ZENG, Qingbei , VENKATRAMAN, Srikanth , SANNIGRAHI, Mousumi , CHEN, Kevin, X. , ANILKUMAR, Gopinadhan, N. , ROSENBLUM, Stuart, B. , KOZLOWSKI, Joseph, A. , NJOROGE, F., George
IPC分类号： C07D491/052 , C07D498/04 , A61K31/436
CPC分类号： C07D498/04 , C07D491/052
摘要： The present invention relates to Tetracyclic Indole Derivatives, compositions comprising at least one Tetracyclic Indole Derivative, and methods of using the Tetracyclic Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
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8.发明公开ANTIVIRAL COMPOUNDS COMPOSED OF THREE ALIGNED ARYL MOIETIES TO TREAT DISEASES SUCH AS HEPATITIS C 审中-公开THREE对齐成一排芳基单元组合抗病毒化合物FOR疾病，如肝炎C的治疗
公开(公告)号：EP2435421A1
公开(公告)日：2012-04-04
申请号：EP10721905.7
申请日：2010-05-28
申请人： Schering Corporation
发明人： CHEN, Kevin, X. , ANILKUMAR, Gopinadhan, N. , ZENG, Qingbei , ROSENBLUM, Stuart, B. , KOZLOWSKI, Joseph, A. , NJOROGE, F., George
IPC分类号： C07D401/14 , C07D403/14 , C07D409/14 , C07D417/14 , A61K31/4184 , A61K31/12
CPC分类号： C07D401/14 , C07D403/14 , C07D409/14 , C07D417/14
摘要： The present invention relates to novel Tricyclic Compounds, compositions comprising at least one Tricyclic Compound, and methods of using Tricyclic Compounds for treating or preventing a viral infection or a virus-related disorder in a patient. The present invention provides Tricyclic Compounds of Formula (I): Non-limiting examples of the Compounds of Formula (I) include compound 44 The Compounds of Formula (II) can be useful for inhibiting HCV viral replication or replicon activity, and for treating or preventing HCV infection in a patient.
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公开(公告)号：EP2303893A1
公开(公告)日：2011-04-06
申请号：EP09763490.1
申请日：2009-06-10
申请人： Schering Corporation
发明人： VENKATRAMAN, Srikanth , ANILKUMAR, Gopinadhan, N. , CHEN, Kevin, X. , VELAZQUEZ, Francisco , ZENG, Qingbei , LIU, Duan , JIANG, Yueheng , KOZLOWSKI, Joseph, A. , NJOROGE, F., George , ROSENBLUM, Stuart, B. , GAVALAS, Stephen, J. , PINTO, Patrick, A. , SELYUTIN, Oleg, B. , VIBULBHAN, Bancha
IPC分类号： C07D491/048 , C07D519/00 , A61P31/14 , A61K31/4439 , A61K31/444
CPC分类号： C07D491/048 , C07D491/04 , C07D519/00
摘要： The present invention relates to Tricyclic Indole Derivatives, compositions comprising at least one Tricyclic Indole Derivatives, and methods of using the Tricyclic Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient
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10.发明公开
公开(公告)号：EP2197842A1
公开(公告)日：2010-06-23
申请号：EP08795611.6
申请日：2008-08-27
申请人： Schering Corporation
发明人： ANILKUMAR, Gopinadhan, N. , BENNETT, Frank , CHAN, Tin-Yau , CHEN, Kevin, X. , SANNIGRAHI, Mousumi , VELAZQUEZ, Francisco , VENKATRAMAN, Srikanth , ZENG, Qingbei , DUCA, Jose, S. , LESBURG, Charles, A. , KOZLOWSKI, Joseph, A. , NJOROGE, F., George , ROSENBLUM, Stuart, B. , SHIH, Neng-Yang , GAVALAS, Stephen, J. , JIANG, Yueheng , PINTO, Patrick, A. , PU, Haiyan , SELYUTIN, Oleg, B. , VIBULBHAN, Bancha , WANG, Li , WU, Wanli , YANG, Weiying , HUANG, Yuhua , HUANG, Hsueh-Cheng , PALERMO, Robert , FELD, Boris
IPC分类号： C07D209/42 , C07D401/04 , C07D401/14 , A61K31/404 , A61P31/12
CPC分类号： C07D417/14 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to 2,3-Substituted Indole Derivatives, compositions comprising at least one 2,3-Substituted Indole Derivative, and methods of using the 2,3-Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
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